Rayan Sabra
Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer
Sabra, Rayan; Billa, Nashiru; Roberts, Clive J.
Authors
Abstract
© 2019 Elsevier B.V. In the present study, we successfully developed a cetuximab-conjugated modified citrus pectin-chitosan nanoparticles for targeted delivery of curcumin (Cet-MCPCNPs) for the treatment of colorectal cancer. In vitro analyses revealed that nanoparticles were spherical with size of 249.33 ± 5.15 nm, a decent encapsulation efficiency (68.43 ± 2.4%) and a ‘smart’ drug release profile. 61.37 ± 0.70% of cetuximab was adsorbed to the surface of the nanoparticles. Cellular uptake studies displayed enhanced internalization of Cet-MCPCNPs in Caco-2 (EGFR +ve) cells, which ultimately resulted in a significant reduction in cancer cell propagation. The cell cycle analysis indicated that Cet- MCPCNPs induced cell death in enhanced percentage of Caco-2 cells by undergoing cell cycle arrest in the G2/M phase. These data suggest that Cet-MCPCNPs represent a new and promising targeting approach for the treatment of colorectal cancer.
Citation
Sabra, R., Billa, N., & Roberts, C. J. (2019). Cetuximab-conjugated chitosan-pectinate (modified) composite nanoparticles for targeting colon cancer. International Journal of Pharmaceutics, 572, Article 118775. https://doi.org/10.1016/j.ijpharm.2019.118775
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 7, 2019 |
Online Publication Date | Oct 31, 2019 |
Publication Date | Dec 15, 2019 |
Deposit Date | Aug 30, 2022 |
Journal | International Journal of Pharmaceutics |
Print ISSN | 0378-5173 |
Electronic ISSN | 1873-3476 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 572 |
Article Number | 118775 |
DOI | https://doi.org/10.1016/j.ijpharm.2019.118775 |
Public URL | https://nottingham-repository.worktribe.com/output/3548526 |
Publisher URL | https://www.sciencedirect.com/science/article/abs/pii/S0378517319308208?via%3Dihub |
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