Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells

Bradshaw, Tracey D.; Junor, Marc; Patan�, Amalia; Clarke, Phil; Thomas, Neil R.; Li, Mei; Mann, Stephen; Turyanska, Lyudmila

Abstract

Colorectal carcinoma (CRC) is the 3rd most common cancer worldwide, thus development of novel therapeutic strategies is imperative. Herein potent, selective dose-dependent antitumor activity of horse spleen apoferritin encapsulated PbS quantum dots (AFt-PbS) against two human-derived colorectal carcinoma cell lines is reported (GI50 ∼ 70 μg mL-1). Following in vitro exposure to AFt-PbS, CRC cells fail to recover proliferative capacity, and undergo apoptosis triggered by the generation of reactive oxygen species (ROS). In stark contrast, the AFt-PbS nanocomposites do not affect the growth and cell cycle of non-tumor human microvessel endothelial HMEC-1 cells (GI50 > 500 μg mL -1). In vivo, AFt-PbS QDs are well tolerated by mice. Neither adverse health nor behavioral indicators were observed throughout the 15 day study. The photoluminescence of AFt-PbS combined with selective antitumor activity offer potential development of AFt-PbS for simultaneous non-invasive imaging and treatment of malignant tissue. © The Royal Society of Chemistry.

Citation

Bradshaw, T. D., Junor, M., Patanè, A., Clarke, P., Thomas, N. R., Li, M., …Turyanska, L. (2013). Apoferritin-encapsulated PbS quantum dots significantly inhibit growth of colorectal carcinoma cells. Journal of Materials Chemistry B, 45, 6254-6260. https://doi.org/10.1039/c3tb21197e

• Journal Article Type: Article
• Acceptance Date: Oct 8, 2013
• Publication Date: Dec 7, 2013
• Deposit Date: Feb 21, 2020
• Journal: Journal of Materials Chemistry B
• Print ISSN: 2050-750X
• Electronic ISSN: 2050-7518
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 45
• Pages: 6254-6260
• DOI: https://doi.org/10.1039/c3tb21197e
• Keywords: General Materials Science; General Chemistry; Biomedical Engineering; General Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/3159493
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2013/TB/c3tb21197e#!divAbstract