R. John Scott
Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system
Scott, R. John; Lian, Lu Yun; Muharram, S. Hanna; Cockayne, Alan; Wood, Stewart J.; Bycroft, Barrie W.; Williams, Paul; Chan, Weng C.
Authors
Lu Yun Lian
S. Hanna Muharram
Alan Cockayne
Stewart J. Wood
Barrie W. Bycroft
PAUL WILLIAMS PAUL.WILLIAMS@NOTTINGHAM.AC.UK
Professor of Molecular Microbiology
Prof WENG CHAN WENG.CHAN@NOTTINGHAM.AC.UK
Professor of Chemical Biology
Abstract
The expression of many staphylococcal virulence factors are regulated by the agr locus via a two-component signal transduction system (TCSTS), which is activated in response to a secreted autoinducer peptide (AIP). By exploiting the unique chemical architecture of the naturally occurring AIP-1, several potent inhibitors of staphylococcal TCSTS were designed and synthesized using either a linear or branched solid-phase approach. These inhibitors are competitive binders and contain the crucial 16-membered side-chain-to-tail thiolactone peptide pharmacophore. © 2003 Elsevier Ltd. All rights reserved.
Citation
Scott, R. J., Lian, L. Y., Muharram, S. H., Cockayne, A., Wood, S. J., Bycroft, B. W., …Chan, W. C. (2003). Side-chain-to-tail thiolactone peptide inhibitors of the staphylococcal quorum-sensing system. Bioorganic and Medicinal Chemistry Letters, 13(15), 2449-2453. https://doi.org/10.1016/S0960-894X%2803%2900497-9
Journal Article Type | Article |
---|---|
Acceptance Date | May 15, 2003 |
Online Publication Date | Jun 20, 2003 |
Publication Date | Aug 4, 2003 |
Deposit Date | Sep 10, 2020 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Print ISSN | 0960-894X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 13 |
Issue | 15 |
Pages | 2449-2453 |
DOI | https://doi.org/10.1016/S0960-894X%2803%2900497-9 |
Public URL | https://nottingham-repository.worktribe.com/output/3105713 |
Publisher URL | https://www.sciencedirect.com/science/article/abs/pii/S0960894X03004979?via%3Dihub |
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