Interstitial glucose profile associated with symptoms attributed to hypoglycemia by otherwise healthy women

Simpson, Elizabeth J.; Holdsworth, Michelle; Macdonald, Ian A.

Abstract

Background: Reports of postprandial symptoms attributed to hypoglycemia by otherwise healthy individuals appear to be relatively common in UK women. Whether these symptoms are related to blood glucose is a contentious issue, which periodic ambulatory blood glucose measurement has failed to resolve. Objective: The authors investigated, using continuous glucose monitoring technology, whether postprandial symptoms are associated with interstitial glucose concentrations (IG) in the hypoglycemic range or with a previous fall in IG. Design: Thirty healthy nonobese women (age 20-48 y) who reported symptoms attributable to hypoglycemia and 20 nonsymptomatic controls wore a subcutaneous probe in abdominal fat for 4-7 d (median: 5 d) and kept a diet and activity diary during this time. Results: Twenty women reported postprandial symptoms; 41 episodes were recorded. When symptomatic, IG was ≤3.3 mmol/L in 5% of cases. A significant fall in IG over the preceding 60 min was observed before autonomic symptoms (P < 0.005). The proportion of total energy intake derived from dietary fat in the symptomatic group was higher than that in the controls (P

• Journal Article Type: Article
• Acceptance Date: Sep 26, 2007
• Online Publication Date: Feb 1, 2008
• Publication Date: Feb 1, 2008
• Deposit Date: Jan 20, 2023
• Publicly Available Date: Jan 27, 2023
• Journal: American Journal of Clinical Nutrition
• Print ISSN: 0002-9165
• Electronic ISSN: 1938-3207
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 87
• Issue: 2
• Pages: 354-361
• DOI: https://doi.org/10.1093/ajcn/87.2.354
• Public URL: https://nottingham-repository.worktribe.com/output/3101829
• Publisher URL: https://academic.oup.com/ajcn/article/87/2/354/4633296?login=false
• Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in The American Journal of Clinical Nutrition (AJCN) following peer review. The version of record Elizabeth J Simpson, Michelle Holdsworth, Ian A Macdonald, Interstitial glucose profile associated with symptoms attributed to hypoglycemia by otherwise healthy women, The American Journal of Clinical Nutrition, Volume 87, Issue 2, February 2008, Pages 354–361 is available online at: https://doi.org/10.1093/ajcn/87.2.354