Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge

Clarkson, A.H.; Paine, S.; Mart�n-Tereso, J.; Kendall, N.R.

Abstract

Ruminants are recognised to suffer from Cu-responsive disorders. Present understanding of Cu transport and metabolism is limited and inconsistent across vets and veterinary professionals. There has been much progress from the studies of the 1980s and early 1990s in cellular Cu transport and liver metabolism which has not been translated into agricultural practice. Cu metabolism operates in regulated pathways of Cu trafficking rather than in pools of Cu lability. Cu in the cell is chaperoned to enzyme production, retention within metallothionein or excretion via the Golgi into the blood. The hepatocyte differs in that Cu-containing caeruloplasmin can be synthesised to provide systemic Cu supply and excess Cu is excreted via bile. The aim of the present review is to improve understanding and highlight the relevant progress in relation to ruminants through the translation of newer findings from medicine and non-ruminant animal models into ruminants.

Citation

Clarkson, A., Paine, S., Martín-Tereso, J., & Kendall, N. (2020). Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge. Nutrition Research Reviews, 33(1), 43-49. https://doi.org/10.1017/S0954422419000180

• Journal Article Type: Article
• Acceptance Date: Aug 6, 2019
• Online Publication Date: Sep 19, 2019
• Publication Date: 2020-06
• Deposit Date: Sep 17, 2019
• Publicly Available Date: Sep 19, 2019
• Journal: Nutrition Research Reviews
• Print ISSN: 0954-4224
• Electronic ISSN: 1475-2700
• Publisher: Cambridge University Press
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 1
• Pages: 43-49
• DOI: https://doi.org/10.1017/S0954422419000180
• Keywords: Ruminant; copper transport; liver metabolism; thiomolybdate
• Public URL: https://nottingham-repository.worktribe.com/output/2624931
• Publisher URL: https://www.cambridge.org/core/journals/nutrition-research-reviews/article/copper-physiology-in-ruminants-trafficking-of-systemic-copper-adaptations-to-variation-in-nutritional-supply-and-thiomolybdate-challenge/F76C0DBAC414102615E203F6976791C1
• Related Public URLs: https://www.cambridge.org/core/journals/nutrition-research-reviews
• Additional Information: The article has been accepted for publication and will appear in a revised form, subsequent to peer review and/or editorial input by Cambridge University Press, in Nutrition Research Reviews published by Cambridge University Press, together with a copyright notice in the name of the copyright holder (Cambridge University Press or the sponsoring Society, as appropriate).
• Contract Date: Sep 17, 2019