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Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge

Clarkson, A.H.; Paine, S.; Mart�n-Tereso, J.; Kendall, N.R.

Authors

A.H. Clarkson

STUART PAINE Stuart.Paine@nottingham.ac.uk
Professor of Pharmacometrics

J. Mart�n-Tereso



Abstract

Ruminants are recognised to suffer from Cu-responsive disorders. Present understanding of Cu transport and metabolism is limited and inconsistent across vets and veterinary professionals. There has been much progress from the studies of the 1980s and early 1990s in cellular Cu transport and liver metabolism which has not been translated into agricultural practice. Cu metabolism operates in regulated pathways of Cu trafficking rather than in pools of Cu lability. Cu in the cell is chaperoned to enzyme production, retention within metallothionein or excretion via the Golgi into the blood. The hepatocyte differs in that Cu-containing caeruloplasmin can be synthesised to provide systemic Cu supply and excess Cu is excreted via bile. The aim of the present review is to improve understanding and highlight the relevant progress in relation to ruminants through the translation of newer findings from medicine and non-ruminant animal models into ruminants.

Citation

Clarkson, A., Paine, S., Martín-Tereso, J., & Kendall, N. (2020). Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge. Nutrition Research Reviews, 33(1), 43-49. https://doi.org/10.1017/S0954422419000180

Journal Article Type Article
Acceptance Date Aug 6, 2019
Online Publication Date Sep 19, 2019
Publication Date 2020-06
Deposit Date Sep 17, 2019
Publicly Available Date Mar 28, 2024
Journal Nutrition Research Reviews
Print ISSN 0954-4224
Electronic ISSN 1475-2700
Publisher Cambridge University Press (CUP)
Peer Reviewed Peer Reviewed
Volume 33
Issue 1
Pages 43-49
DOI https://doi.org/10.1017/S0954422419000180
Keywords Ruminant; copper transport; liver metabolism; thiomolybdate
Public URL https://nottingham-repository.worktribe.com/output/2624931
Publisher URL https://www.cambridge.org/core/journals/nutrition-research-reviews/article/copper-physiology-in-ruminants-trafficking-of-systemic-copper-adaptations-to-variation-in-nutritional-supply-and-thiomolybdate-challenge/F76C0DBAC414102615E203F6976791C1
Related Public URLs https://www.cambridge.org/core/journals/nutrition-research-reviews
Additional Information The article has been accepted for publication and will appear in a revised form, subsequent to peer review and/or editorial input by Cambridge University Press, in Nutrition Research Reviews published by Cambridge University Press, together with a copyright notice in the name of the copyright holder (Cambridge University Press or the sponsoring Society, as appropriate).

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