Cardiovascular Stem Cell Applications in Experimental Animal Models

Jeyapalan, Jennie N.; Cockcroft, James; Rizvanov, Albert A.; Haider, Khawaja H.; Rutland, Catrin S.

Abstract

Stem cells are increasingly used in various species for differing diseases, most frequently experimentally. In addition, several animals are also used as models for both veterinary and human medicine. Differing stem cell types have been trialed with naturally occurring diseases and animal models. Cardiomyopathy is a significant cause of death and morbidity in veterinary medicine, with some dog breeds reporting rates of up to 50% of the population being affected. Retrograde coronary venous allogeneic adipose-derived mesenchymal stem cell delivery and allogeneic cardiosphere-derived cells have been used experimentally for dilated cardiomyopathy. Although safe, the efficacy of these treatments was not yet shown in these canine patients. In addition, the degenerative valvular disease has shown improvement following puppy deciduous teeth-derived stem cell administration. Preclinical studies into acute myocardial infarction and chronic ischemia models have successfully restored cardiac function, regenerated damaged cardiomyocytes, and attenuated cardiac remodeling. In addition to these trials and others, treatment to restore vasculature has also shown much growth over several years. It consists of several disorders, i.e., wound healing, musculoskeletal problems, etc. Although these technologies are relatively new, the possibilities of these regenerative therapies provide exciting new avenues for research and treatment.

• Online Publication Date: Jul 6, 2023
• Publication Date: 2023
• Deposit Date: Jul 11, 2023
• Publicly Available Date: Jul 7, 2025
• Pages: 465-490
• Book Title: Cardiovascular Applications of Stem Cells
• ISBN: 9789819907212
• DOI: https://doi.org/10.1007/978-981-99-0722-9_16
• Public URL: https://nottingham-repository.worktribe.com/output/22992263
• Publisher URL: https://link.springer.com/chapter/10.1007/978-981-99-0722-9_16