Mandeep S. Dhak
A Domino Radical Amidation/Semipinacol Approach to All-Carbon Quaternary Centers Bearing an Aminomethyl Group
Dhak, Mandeep S.; Arunprasath, Dhanarajan; Argent, Stephen P.; Cuthbertson, James David
Authors
ARUNPRASATH DHANARAJAN ARUNPRASATH.DHANARAJAN@NOTTINGHAM.AC.UK
Research Fellow in Synthetic Organic Chemistry
STEPHEN ARGENT stephen.argent@nottingham.ac.uk
Senior Research Fellow
James David Cuthbertson
Abstract
A photoredox-mediated radical amidation ring-expansion sequence that enables the generation of all-carbon quaternary centers bearing a protected aminomethyl substituent is described. The methodology can be applied to both styrene and unactivated alkene substrates generating structurally diverse sp3-rich amine derivatives in a concise manner.
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 2, 2023 |
Online Publication Date | Jul 24, 2023 |
Publication Date | Aug 21, 2023 |
Deposit Date | Jun 28, 2023 |
Publicly Available Date | Jul 25, 2024 |
Journal | Chemistry - A European Journal |
Print ISSN | 0947-6539 |
Electronic ISSN | 1521-3765 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 29 |
Issue | 47 |
Article Number | e202300922 |
DOI | https://doi.org/10.1002/chem.202300922 |
Keywords | Aminofunctionalisation, ring expansion, nitrogen-centred radicals, Photoredox catalysis, semipinacol rearrangement |
Public URL | https://nottingham-repository.worktribe.com/output/22172826 |
Publisher URL | https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202300922 |
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A Domino Radical Amidation/Semipinacol Approach to All-Carbon Quaternary Centers Bearing an Aminomethyl Group
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