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Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006)

Wilde, Craig; Poostchi, Ali; Mehta, Rajnikant L.; Hillman, Jonathan G.; MacNab, Hamish K.; Messina, Marco; Monaco, Gaspare; Vernon, Stephen A.; Amoaku, Winfried M.

Authors

Craig Wilde

Ali Poostchi

Rajnikant L. Mehta

Jonathan G. Hillman

Hamish K. MacNab

Marco Messina

Gaspare Monaco

Stephen A. Vernon

WINFRIED AMOAKU winfried.amoaku@nottingham.ac.uk
Clinical Assoc Prof & Reader in Ophthalmology & Visual Sciences



Abstract

Purpose: There is paucity of data on the epidemiology of peripapillary choroidal neovascularisartion (PPCNV). Our aim was to determine prevalence of PPCNV in the elderly UK population of Bridlington residents aged ≥65 years.
Methods: Eyes with PPCNV in the Bridlington Eye Assessment Project (BEAP) database of 3475 participants were analysed. PPCNV outline was drawn, its area measured, and clockhour involvement of disc circumference recorded. Location and shortest distance from the lesion edge to fovea were recorded. Masked grading for age-related maculopathy (ARM)/reticular pseudodrusen (RPD) within the ETDRS grid was assigned for each eye using a modified Rotterdam scale. Peripapillary retinal pigment epithelial (RPE) changes/drusen were recorded. Visual acuity (VA) and demographic details analysed separately were merged with grading data.
Results: PPCNV were identified in 10 subjects, and were bilateral in 2 (20%), a population prevalence of 0.29%, and 0.06% bilaterality. Gender specific prevalence were 0.36%, 0.19% for females and males respectively. Age ranged from 66 to 85 years (mean 76.3 [SD 6.4].
PPCNV were located nasal to disc in 41.7%, measuring .46-7.93mm2 [mean 2.81mm2 (SD 2.82)]. All PPCNV eyes had peripapillary RPE changes. One subject had no ARM, 1 angioid streaks, and 30% RPD. No direct foveal involvement, or reduced VA attributable to PPCNV was observed.
Conclusion: PPCNV were infrequent in this population, more common in females, and often located nasal to the disc, without foveal extension. Peripapillary degenerative changes were universal, and strong association with ARM was observed in eyes with PPCNV. Typically, PPCNV were asymptomatic with VA preservation.

Journal Article Type Article
Publication Date Mar 31, 2019
Journal Eye
Print ISSN 0950-222X
Electronic ISSN 1476-5454
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 33
Issue 3
Pages 451-458
APA6 Citation Wilde, C., Poostchi, A., Mehta, R. L., Hillman, J. G., MacNab, H. K., Messina, M., …Amoaku, W. M. (2019). Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006). Eye, 33(3), 451-458. doi:10.1038/s41433-018-0232-y
DOI https://doi.org/10.1038/s41433-018-0232-y
Keywords Ophthalmology; General Arts and Humanities
Publisher URL https://www.nature.com/articles/s41433-018-0232-y

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