Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006)

Wilde, Craig; Poostchi, Ali; Mehta, Rajnikant L.; Hillman, Jonathan G.; MacNab, Hamish K.; Messina, Marco; Monaco, Gaspare; Vernon, Stephen A.; Amoaku, Winfried M.

Abstract

© 2018, The Royal College of Ophthalmologists. Purpose: There is paucity of data on the epidemiology of peripapillary choroidal neovascularisartion (PPCNV). Our aim was to determine prevalence of PPCNV in the elderly UK population of Bridlington residents aged ≥65 years. Methods: Eyes with PPCNV in the Bridlington eye assessment project (BEAP) database of 3475 participants were analysed. PPCNV outline was drawn, its area measured, and clock-hour involvement of disc circumference recorded. Location and shortest distance from the lesion edge to fovea were recorded. Masked grading for age-related maculopathy (ARM)/reticular pseudodrusen (RPD) within the ETDRS grid was assigned for each eye using a modified Rotterdam scale. Peripapillary retinal pigment epithelial (RPE) changes/drusen were recorded. Visual acuity (VA) and demographic details analysed separately were merged with grading data. Results: PPCNV were identified in ten subjects, and were bilateral in two (20%), a population prevalence of 0.29%, and 0.06% bilaterality. Gender-specific prevalence were 0.36% and 0.19% for females and males, respectively. Age ranged from 66 to 85 years [mean 76.3 (SD 6.4)]. PPCNV were located nasal to disc in 41.7%, measuring 0.46–7.93 mm 2 [mean 2.81 mm 2 (SD 2.82)]. All PPCNV eyes had peripapillary RPE changes. One subject had no ARM, 1 angioid streaks, and 30% RPD. No direct foveal involvement, or reduced VA attributable to PPCNV was observed. Conclusion: PPCNV were infrequent in this population, more common in females, and often located nasal to the disc, without foveal extension. Peripapillary degenerative changes were universal, and strong association with ARM was observed in eyes with PPCNV. Typically, PPCNV were asymptomatic with VA preservation.

Citation

Wilde, C., Poostchi, A., Mehta, R. L., Hillman, J. G., MacNab, H. K., Messina, M., …Amoaku, W. M. (2019). Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006). Eye, 33(3), 451-458. https://doi.org/10.1038/s41433-018-0232-y

• Journal Article Type: Article
• Acceptance Date: Jun 5, 2018
• Online Publication Date: Oct 12, 2018
• Publication Date: Mar 1, 2019
• Deposit Date: Apr 18, 2019
• Publicly Available Date: Apr 18, 2019
• Journal: Eye
• Print ISSN: 0950-222X
• Electronic ISSN: 1476-5454
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 33
• Issue: 3
• Pages: 451-458
• DOI: https://doi.org/10.1038/s41433-018-0232-y
• Keywords: Ophthalmology; General Arts and Humanities
• Public URL: https://nottingham-repository.worktribe.com/output/1828948
• Publisher URL: https://www.nature.com/articles/s41433-018-0232-y