Ferromagnetic Cytocompatible Glass-Ceramic Porous Microspheres for Magnetic Hyperthermia Applications

Molinar‐Díaz, Jesús; Woodliffe, John Luke; Milborne, Benjamin; Murrell, Lauren; Islam, Md Towhidul; Steer, Elisabeth; Weston, Nicola; Morley, Nicola A.; Brown, Paul D.; Ahmed, Ifty

Abstract

Highly porous, ferromagnetic glass-ceramic P40-Fe3O4 microspheres (125–212 µm) with enhanced cytocompatibility have been manufactured for the first time via a facile, rapid, single-stage flame spheroidization process. Dispersions of Fe3O4 and Ca2Fe2O5 domains (≈10 µm) embedded within P40 (40P2O5-16CaO-24MgO-20Na2O in mol%) phosphate-based glass matrices show evidence for remanent magnetization (0.2 Am2 kg−1) and provide for controlled induction heating to a constant level of 41.9 °C, making these materials highly appropriate for localized magnetic hyperthermia applications. Complementary, cytocompatibility investigations confirm the suitability of P40-Fe3O4 porous microspheres for biomedical applications. It is suggested that the flame-spheroidization process opens up new opportunities for the development of innovative synergistic biomaterials, toward bone-tissue regenerative applications.

Citation

Molinar‐Díaz, J., Woodliffe, J. L., Milborne, B., Murrell, L., Islam, M. T., Steer, E., …Ahmed, I. (2023). Ferromagnetic Cytocompatible Glass-Ceramic Porous Microspheres for Magnetic Hyperthermia Applications. Advanced Materials Interfaces, 10(11), Article 2202089. https://doi.org/10.1002/admi.202202089

• Journal Article Type: Article
• Acceptance Date: Jan 17, 2023
• Online Publication Date: Mar 2, 2023
• Publication Date: Apr 14, 2023
• Deposit Date: Mar 5, 2023
• Publicly Available Date: Apr 4, 2023
• Journal: Advanced Materials Interfaces
• Electronic ISSN: 2196-7350
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 11
• Article Number: 2202089
• DOI: https://doi.org/10.1002/admi.202202089
• Keywords: Bioactive glasses; magnetic hyperthermia; magnetic particles; porous microspheres
• Public URL: https://nottingham-repository.worktribe.com/output/17947142
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1002/admi.202202089