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Process parameter optimisation for manufacturing porous bioactive silicate glass microspheres via flame spheroidisation: The goldilocks effect

Islam, Md Towhidul; Parsons, Andrew J.; Nuzulia, Nur Aisyah; Sari, Yessie W; Ren, Hong; Booth, Jonathan; Ahmed, Ifty

Authors

Md Towhidul Islam

Nur Aisyah Nuzulia

Yessie W Sari

Hong Ren

Jonathan Booth



Abstract

This study investigated the influence of flame spheroidisation process parameters for successfully manufacturing solid (dense) and highly porous microspheres from Food and Drug Administration approved bioactive 45S5 glass and 45S5 with addition of viscosity modifiers (i.e. 2 and 5 mol% borax and V2O5), compared against successfully processed phosphate glass microspheres (termed P40). Characterisation studies performed included thermal analysis (SDT), glass viscosity measurements using high temperature rotational viscometry and hot stage microscopy, X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis. This study revealed that aside from intrinsic material properties (i.e. melt temperature and viscosity profiles), process parameters including starting glass particle size, cooling rate and gas flow rates were important factors in achieving the desired porous glass microsphere morphology. Considering the above influential factors, a processing model has been proposed for the manufacture of highly porous microspheres from bioactive silicate glasses.

Journal Article Type Article
Acceptance Date May 9, 2023
Online Publication Date May 25, 2023
Publication Date Aug 15, 2023
Deposit Date May 26, 2023
Publicly Available Date May 26, 2023
Journal Journal of Non-Crystalline Solids
Print ISSN 0022-3093
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 614
Article Number 122393
DOI https://doi.org/10.1016/j.jnoncrysol.2023.122393
Keywords Bioactive glasses; Porous microspheres; Viscosity; Thermal properties; Flame spheroidisation
Public URL https://nottingham-repository.worktribe.com/output/21112008
Publisher URL https://www.sciencedirect.com/science/article/pii/S0022309323002594
Additional Information This article is maintained by: Elsevier; Article Title: Process parameter optimisation for manufacturing porous bioactive silicate glass microspheres via flame spheroidisation: The goldilocks effect; Journal Title: Journal of Non-Crystalline Solids; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jnoncrysol.2023.122393; Content Type: article; Copyright: © 2023 The Author(s). Published by Elsevier B.V.

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