Process parameter optimisation for manufacturing porous bioactive silicate glass microspheres via flame spheroidisation: The goldilocks effect

Islam, Md Towhidul; Parsons, Andrew J.; Nuzulia, Nur Aisyah; Sari, Yessie W; Ren, Hong; Booth, Jonathan; Ahmed, Ifty

Abstract

This study investigated the influence of flame spheroidisation process parameters for successfully manufacturing solid (dense) and highly porous microspheres from Food and Drug Administration approved bioactive 45S5 glass and 45S5 with addition of viscosity modifiers (i.e. 2 and 5 mol% borax and V2O5), compared against successfully processed phosphate glass microspheres (termed P40). Characterisation studies performed included thermal analysis (SDT), glass viscosity measurements using high temperature rotational viscometry and hot stage microscopy, X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis. This study revealed that aside from intrinsic material properties (i.e. melt temperature and viscosity profiles), process parameters including starting glass particle size, cooling rate and gas flow rates were important factors in achieving the desired porous glass microsphere morphology. Considering the above influential factors, a processing model has been proposed for the manufacture of highly porous microspheres from bioactive silicate glasses.

Citation

Islam, M. T., Parsons, A. J., Nuzulia, N. A., Sari, Y. W., Ren, H., Booth, J., & Ahmed, I. (2023). Process parameter optimisation for manufacturing porous bioactive silicate glass microspheres via flame spheroidisation: The goldilocks effect. Journal of Non-Crystalline Solids, 614, Article 122393. https://doi.org/10.1016/j.jnoncrysol.2023.122393

• Journal Article Type: Article
• Acceptance Date: May 9, 2023
• Online Publication Date: May 25, 2023
• Publication Date: Aug 15, 2023
• Deposit Date: May 26, 2023
• Publicly Available Date: May 26, 2023
• Journal: Journal of Non-Crystalline Solids
• Print ISSN: 0022-3093
• Publisher: Elsevier BV
• Peer Reviewed: Peer Reviewed
• Volume: 614
• Article Number: 122393
• DOI: https://doi.org/10.1016/j.jnoncrysol.2023.122393
• Keywords: Bioactive glasses; Porous microspheres; Viscosity; Thermal properties; Flame spheroidisation
• Public URL: https://nottingham-repository.worktribe.com/output/21112008
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0022309323002594
• Additional Information: This article is maintained by: Elsevier; Article Title: Process parameter optimisation for manufacturing porous bioactive silicate glass microspheres via flame spheroidisation: The goldilocks effect; Journal Title: Journal of Non-Crystalline Solids; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jnoncrysol.2023.122393; Content Type: article; Copyright: © 2023 The Author(s). Published by Elsevier B.V.