Erin Burke Quinlan
Peer victimization and its impact on adolescent brain development and psychopathology
Authors
Edward D. Barker
Qiang Luo
Tobias Banaschewski
Arun L. W. Bokde
Uli Bromberg
Christian
Sylvane
Herta Flor
Vincent Frouin
Hugh Garavan
Bader Chaarani
Professor PENNY GOWLAND penny.gowland@nottingham.ac.uk
Professor of Physics
Andreas Heinz
Jean-Luc Martinot
Martinot
Frauke Nees
Dimitri Papadopoulos Orfanos
Paus
Luise Poustka
Sarah Hohmann
Michael N. Smolka
Juliane H.
Henrik Walter
Robert Whelan
Gunter Schumann
IMAGEN Consortium
Abstract
Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = −2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004–0.109). This was also true for the left caudate (95% CI = 0.002–0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.
Citation
Quinlan, E. B., Barker, E. D., Luo, Q., Banaschewski, T., Bokde, A. L. W., Bromberg, U., …IMAGEN Consortium. (2018). Peer victimization and its impact on adolescent brain development and psychopathology. Molecular Psychiatry, https://doi.org/10.1038/s41380-018-0297-9
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 9, 2018 |
Online Publication Date | Dec 12, 2018 |
Publication Date | Dec 12, 2018 |
Deposit Date | Jan 8, 2019 |
Publicly Available Date | Jun 13, 2019 |
Journal | Molecular Psychiatry |
Print ISSN | 1359-4184 |
Electronic ISSN | 1476-5578 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1038/s41380-018-0297-9 |
Keywords | Molecular Biology; Cellular and Molecular Neuroscience; Psychiatry and Mental health |
Public URL | https://nottingham-repository.worktribe.com/output/1450072 |
Publisher URL | https://www.nature.com/articles/s41380-018-0297-9 |
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