Peer victimization and its impact on adolescent brain development and psychopathology

Quinlan, Erin Burke; Barker, Edward D.; Luo, Qiang; Banaschewski, Tobias; Bokde, Arun L. W.; Bromberg, Uli; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Chaarani, Bader; Gowland, Penny; Heinz, Andreas; Martinot, Jean-Luc; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Poustka, Luise; Hohmann, Sarah; Smolka, Michael N.; Walter, Henrik; Whelan, Robert; Schumann, Gunter; IMAGEN Consortium

doi:10.1038/s41380-018-0297-9

Peer victimization and its impact on adolescent brain development and psychopathology

Authors

Erin Burke Quinlan

Edward D. Barker

Qiang Luo

Tobias Banaschewski

Arun L. W. Bokde

Uli Bromberg

Christian

Sylvane

Herta Flor

Vincent Frouin

Hugh Garavan

Bader Chaarani

Professor PENNY GOWLAND penny.gowland@nottingham.ac.uk
Professor of Physics

Andreas Heinz

Jean-Luc Martinot

Martinot

Frauke Nees

Dimitri Papadopoulos Orfanos

Paus

Luise Poustka

Sarah Hohmann

Michael N. Smolka

Juliane H.

Henrik Walter

Robert Whelan

Gunter Schumann

IMAGEN Consortium

Abstract

Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = −2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004–0.109). This was also true for the left caudate (95% CI = 0.002–0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.

Citation

Quinlan, E. B., Barker, E. D., Luo, Q., Banaschewski, T., Bokde, A. L. W., Bromberg, U., …IMAGEN Consortium. (2018). Peer victimization and its impact on adolescent brain development and psychopathology. Molecular Psychiatry, https://doi.org/10.1038/s41380-018-0297-9

Journal Article Type	Article
Acceptance Date	Oct 9, 2018
Online Publication Date	Dec 12, 2018
Publication Date	Dec 12, 2018
Deposit Date	Jan 8, 2019
Publicly Available Date	Jun 13, 2019
Journal	Molecular Psychiatry
Print ISSN	1359-4184
Electronic ISSN	1476-5578
Publisher	Nature Publishing Group
Peer Reviewed	Peer Reviewed
DOI	https://doi.org/10.1038/s41380-018-0297-9
Keywords	Molecular Biology; Cellular and Molecular Neuroscience; Psychiatry and Mental health
Public URL	https://nottingham-repository.worktribe.com/output/1450072
Publisher URL	https://www.nature.com/articles/s41380-018-0297-9