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Low molecular weight nucleoside gelators: a platform for protein aggregation inhibition

Johnson, Litty; Faidra Angelerou, Maria Galini; Surikutchi, Bhanu Teja; Allen, Stephanie; Zelzer, Mischa; Marlow, Maria

Authors

Litty Johnson

Maria Galini Faidra Angelerou

Bhanu Teja Surikutchi

STEPHANIE ALLEN stephanie.allen@nottingham.ac.uk
Professor of Pharmaceutical Biophysics



Abstract

Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics because of their excellent biocompatibility. However, the influence of these gelators on protein aggregation inhibition has not yet been studied. Protein aggregation is the most significant cause of protein instability and can severely impact the biological activity of the protein, impairing the quality and safety of the formulation. Herein, we report the ability of a nucleoside-based gelator, N4-octanoyl-2′-deoxycytidine, to inhibit protein aggregation. Using turbidimetric, spectroscopic, and microscopic methods, we demonstrate that protein aggregation inhibition is dependent on gelator concentration. Moreover, we have found that the protein is still functionally active in the hydrogel.

Journal Article Type Article
Publication Date Nov 29, 2018
Journal Molecular Pharmaceutics
Print ISSN 1543-8384
Electronic ISSN 1543-8392
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
APA6 Citation Johnson, L., Faidra Angelerou, M. G., Surikutchi, B. T., Allen, S., Zelzer, M., & Marlow, M. (2018). Low molecular weight nucleoside gelators: a platform for protein aggregation inhibition. Molecular Pharmaceutics, https://doi.org/10.1021/acs.molpharmaceut.8b01013
DOI https://doi.org/10.1021/acs.molpharmaceut.8b01013
Keywords Molecular Medicine; Drug Discovery; Pharmaceutical Science
Publisher URL https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b01013

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