@article { , title = {Low Molecular Weight Nucleoside Gelators: A Platform for Protein Aggregation Inhibition}, abstract = {© Copyright 2018 American Chemical Society. Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics because of their excellent biocompatibility. However, the influence of these gelators on protein aggregation inhibition has not yet been studied. Protein aggregation is the most significant cause of protein instability and can severely impact the biological activity of the protein, impairing the quality and safety of the formulation. Herein, we report the ability of a nucleoside-based gelator, N4-octanoyl-2′-deoxycytidine, to inhibit protein aggregation. Using turbidimetric, spectroscopic, and microscopic methods, we demonstrate that protein aggregation inhibition is dependent on gelator concentration. Moreover, we have found that the protein is still functionally active in the hydrogel.}, doi = {10.1021/acs.molpharmaceut.8b01013}, eissn = {1543-8392}, issn = {1543-8384}, issue = {1}, journal = {Molecular Pharmaceutics}, note = {12 mo. embargo. OL 11/12/2018}, pages = {462-467}, publicationstatus = {Published}, publisher = {American Chemical Society}, url = {https://nottingham-repository.worktribe.com/output/1401804}, volume = {16}, keyword = {Molecular Medicine, Drug Discovery, Pharmaceutical Science}, year = {2019}, author = {Johnson, Litty and Faidra Angelerou, Maria Galini and Surikutchi, Bhanu Teja and Allen, Stephanie and Zelzer, Mischa and Marlow, Maria} }