Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody–associated vasculitis

Pearce, Fiona A.; Craven, Anthea; Merkel, Peter A.; Luqmani, Raashid A.; Watts, Richard A.

Abstract

© The Author 2017. Objectives. There are few data on clinical profiles of ANCA-associated vasculitis (AAV) in different ethnic populations. The aim of this study was to examine the differences in the ANCA type and clinical features of AAV between populations using the Diagnostic and Classification Criteria in Vasculitis Study (DCVAS) dataset. Methods. The DCVAS is an international, multicentre, observational study recruiting in 133 sites. Eight ethnic categories were analysed: Northern European, Caucasian American, Southern European, Middle Eastern/Turkish, Chinese, Japanese, Indian subcontinent and other. ANCA type was categorized as myeloperoxidase (MPO), PR3 and ANCA negative. Organ system involvement was recorded using a standard dataset. Differences were analysed by chi-squared tests using a Bonferroni correction and logistic regression (adjusting for age and sex). Northern European was the reference population. Results. Data from 1217 patients with AAV were available and the 967 (79.5%) patients recruited by rheumatology departments were analysed to reduce confounding by recruitment specialty. There were differences in ANCA type between ethnic categories (P < 0.001): MPO-ANCA was more common than PR3-ANCA in Japanese, Chinese and Southern Europeans; PR3-ANCA was more common in the other groups. Compared with Northern Europeans, Japanese had a nearly 60-fold increased chance of having MPO-ANCA (vs PR3-ANCA) [odds ratio (OR) 59.2 (95% CI 8.0, 440.7), P < 0.001] and Chinese had a nearly 7-times increased chance [OR 6.8 (95% CI 2.6, 17.8), P < 0.001]. Ophthalmologic and otorhinolaryngologic involvement were less common in Japanese and Chinese populations than Northern Europeans; otherwise, there were few differences in organ involvement between ethnic groups. Conclusion. This study confirms the previously observed differential occurrence of MPO-AAV and PR3- AAV between different ethnic groups.

Citation

Pearce, F. A., Craven, A., Merkel, P. A., Luqmani, R. A., & Watts, R. A. (2017). Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody–associated vasculitis. Rheumatology, 56(11), 1962-1969. https://doi.org/10.1093/rheumatology/kex293

• Journal Article Type: Article
• Acceptance Date: Jul 19, 2017
• Online Publication Date: Aug 10, 2017
• Publication Date: Nov 1, 2017
• Deposit Date: Nov 28, 2018
• Publicly Available Date: Dec 5, 2018
• Journal: Rheumatology
• Electronic ISSN: 1462-0332
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 56
• Issue: 11
• Pages: 1962-1969
• DOI: https://doi.org/10.1093/rheumatology/kex293
• Keywords: ANCA-vasculitis, epidemiology, PR3-ANCA, MPO-ANCA
• Public URL: https://nottingham-repository.worktribe.com/output/1318116
• Publisher URL: https://academic.oup.com/rheumatology/article/56/11/1962/4080298
• Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Rheumatology following peer review. The version of record Fiona A Pearce, Anthea Craven, Peter A Merkel, Raashid A Luqmani, Richard A Watts; Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody–associated vasculitis, Rheumatology, Volume 56, Issue 11, 1 November 2017, Pages 1962–1969 is available online at: https://academic.oup.com/rheumatology/article/56/11/1962/4080298.
• Contract Date: Nov 28, 2018