A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up

Johnston, S. J.; Kenny, F. S.; Syed, B. M.; Robertson, J. F. R.; Pinder, S. E.; Winterbottom, L.; Ellis, I. O.; Blamey, R. W.; Cheung, K. L.

Abstract

Background
Long-term analysis of a randomised trial in Nottingham comparing tamoxifen versus surgery as initial treatment demonstrated that in oestrogen receptor (ER)-unselected cases, surgery achieved better local control, with no difference in overall survival. It was suggested that for patients with ER-rich tumours, local control and survival may be comparable. We now present long-term follow-up of a randomised trial designed to address this clinical scenario.

Patients and methods
One hundred and fifty three fit elderly (?70 years) women with clinically node-negative primary invasive breast carcinoma

Citation

Johnston, S. J., Kenny, F. S., Syed, B. M., Robertson, J. F. R., Pinder, S. E., Winterbottom, L., …Cheung, K. L. (2012). A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up. Annals of Oncology, 23(9), 2296-2300. https://doi.org/10.1093/annonc/mdr630

• Journal Article Type: Article
• Acceptance Date: Dec 20, 2011
• Online Publication Date: Jan 6, 2020
• Publication Date: 2012-09
• Deposit Date: Nov 28, 2018
• Journal: Annals of Oncology
• Print ISSN: 0923-7534
• Electronic ISSN: 1569-8041
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 9
• Pages: 2296-2300
• DOI: https://doi.org/10.1093/annonc/mdr630
• Public URL: https://nottingham-repository.worktribe.com/output/1138781
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0923753419351993?via%3Dihub