Type 2 diabetes and risk of hospital admission or death for chronic liver diseases

Wild, Sarah; Morling, Joanne R.; McAllister, David; Kerssens, Jan; Fischbacher, Colin; Parkes, Julie; Roderick, Paul; Sattar, Naveed; Byrne, Christopher

Abstract

Background & Aims The impact of type 2 diabetes (T2DM) on hospital admissions and deaths due to common chronic liver diseases (CLDs) is uncertain. Our aim was to investigate associations between T2DM and CLDs in a national retrospective cohort study and to investigate the role of sex and socio-economic status (SES). Methods We used International Classification of Disease codes to identify incident alcoholic liver disease (ALD), autoimmune liver disease, haemochromatosis, hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) and viral liver disease from linked diabetes, hospital, cancer and death records for people of 40-89 years of age in Scotland 2004-2013. We used quasi Poisson regression to estimate rate ratios (RR). Results There were 6667 and 33624 first mentions of CLD in hospital, cancer and death records over ?1.8 and 24 million person-years in people with and without T2DM, respectively. The most common liver disease was ALD among people without diabetes and was NAFLD among people with T2DM. Age-adjusted RR for T2DM compared to the non-diabetic population (95% confidence intervals) varied between 1.27 (1.04-1.55) for autoimmune liver disease and 5.36 (4.41-6.51) for NAFLD. RRs were lower for men than women and for more compared to less deprived populations for both ALD and NAFLD. Conclusions T2DM is associated with increased risk of hospital admission or death for all common CLDs and the strength of the association varies by type of CLD, sex and SES. Increasing prevalence of T2DM is likely to result in increasing burden of all CLDs.

Citation

Wild, S., Morling, J. R., McAllister, D., Kerssens, J., Fischbacher, C., Parkes, J., …Byrne, C. (2016). Type 2 diabetes and risk of hospital admission or death for chronic liver diseases. Journal of Hepatology, 64(6), 1358-1364. https://doi.org/10.1016/j.jhep.2016.01.014

• Journal Article Type: Article
• Acceptance Date: Jan 14, 2016
• Online Publication Date: Jan 23, 2016
• Publication Date: Jun 1, 2016
• Deposit Date: Mar 26, 2018
• Publicly Available Date: Jan 22, 2019
• Journal: Journal of Hepatology
• Print ISSN: 0168-8278
• Electronic ISSN: 1600-0641
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 64
• Issue: 6
• Pages: 1358-1364
• DOI: https://doi.org/10.1016/j.jhep.2016.01.014
• Public URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962439762&partnerID=40&md5=37eb9cab85c365fa5ef777cc5969f2e4
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0168827816000209
• Additional Information: This article is maintained by: Elsevier; Article Title: Type 2 diabetes and risk of hospital admission or death for chronic liver diseases; Journal Title: Journal of Hepatology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jhep.2016.01.014