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Outputs (633)

Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society (2024)
Journal Article
El-Boghdadly, K., Levy, N. A., Fawcett, W. J., Knaggs, R. D., Laycock, H., Baird, E., Cox, F. J., Eardley, W., Kemp, H., Malpus, Z., Partridge, A., Partridge, J., Patel, A., Price, C., Robinson, J., Russon, K., Walumbe, J., & Lobo, D. N. (2024). Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society. Anaesthesia, 79(11), 1220-1236. https://doi.org/10.1111/anae.16391

This is a consensus document produced by expert members of a Working Party established by the Association of Anaesthetists and the British Pain Society. It has been seen and approved by their Committee and Board respectively. It is supported by the E... Read More about Peri-operative pain management in adults: a multidisciplinary consensus statement from the Association of Anaesthetists and the British Pain Society.

Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom (2024)
Journal Article
Al-Hadyan, K. S., Storr, S. J., Zaitoun, A. M., Lobo, D. N., & Martin, S. G. (2024). Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom. Diseases, 12(10), Article 227. https://doi.org/10.3390/diseases12100227

Background: Poor survival outcomes in periampullary cancer highlight the need for improvement in biomarkers and the development of novel therapies. Redox proteins, including the thioredoxin system, play vital roles in cellular antioxidant systems. Me... Read More about Thioredoxin System Protein Expression in Carcinomas of the Pancreas, Distal Bile Duct, and Ampulla in the United Kingdom.

Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation (2024)
Journal Article
Portelli, M., Ketelaar, M., Bates, S., Csomor, E., Shaw, D., Emsley, J., Brightling, C., Hall, I., Affleck, K., Edwards, M., Nawijn, M., Koppelman, G., Van Oosterhout, A., & Sayers, I. (2024). Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation. Clinical and Experimental Allergy, 54(12), 984-985. https://doi.org/10.1111/cea.14562

Introduction: The interleukin-33/interleukin-1 receptor-like-1 (IL-33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these variants'... Read More about Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation.

Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task (2024)
Journal Article
Hock, R. M., Owusu-Amoah, N., Waite, L., Muir, C., Stevenson, C. W., Bonardi, C., & Cassaday, H. J. (2024). Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task. Behavioral Neuroscience, 138(6), 420-432. https://doi.org/10.1037/bne0000603

Healthy cognition requires inhibitory modulation of associative learning; conversely, impaired inhibitory discrimination is implicated in behavioral disorders. The medial prefrontal cortex (mPFC) and its dopamine innervation are key to understanding... Read More about Effects of manipulating prefrontal activity and dopamine D1 receptor signalling in an appetitive feature-negative discrimination learning task.

Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia (2024)
Journal Article
Lansbury, L., McKeever, T. M., Lawrence, H., Pick, H., Baskaran, V., Edwards-Pritchard, R. C., Ashton, D., Rodrigo, C., Daniel, P., Litt, D., Eletu, S., Parmar, H., Sheppard, C. L., Ladhani, S., Trotter, C., & Lim, W. S. (2024). Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia. Journal of Infection, 89(5), Article 106277. https://doi.org/10.1016/j.jinf.2024.106277

Objectives

We aimed to determine the prevalence of and risk factors for nasopharyngeal and oral pneumococcal carriage in adults with community-acquired pneumonia (CAP), and the relationship between carried and disease-causing serotypes.

Methods... Read More about Carriage of Streptococcus pneumoniae in adults hospitalised with community-acquired pneumonia.

Structuring white rice with gellan gum reduces the glycemic response in healthy humans (2024)
Journal Article
Alshammari, N. A., Riches, K., Muttakin, S., Hoad, C. L., Strkalj, L., Gouseti, O., Bakalis, S., Lovegrove, A., Spiller, R. C., Gowland, P. A., Aithal, G. P., Yakubov, G. E., Taylor, M. A., & Marciani, L. (2024). Structuring white rice with gellan gum reduces the glycemic response in healthy humans. Food Research International, 196, Article 115090. https://doi.org/10.1016/j.foodres.2024.115090

White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that addition of f... Read More about Structuring white rice with gellan gum reduces the glycemic response in healthy humans.

Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies (2024)
Journal Article
Jensen, M. D., West, J., Crooks, C., Morling, J. R., Kraglund, F., Card, T., Askgaard, G., & Jepsen, P. (2024). Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies. American Journal of Gastroenterology, https://doi.org/10.14309/ajg.0000000000003077

INTRODUCTION:
Patients with alcohol-related cirrhosis (ALD cirrhosis) have an increased risk of primary liver cancer (hepatocellular carcinoma [HCC] or intrahepatic cholangiocarcinoma [iCCA]). England recommends surveillance for HCC in these patien... Read More about Primary Liver Cancer Risk and Mortality in Patients With Alcohol-Related Cirrhosis in England and Denmark: Observational Cohort Studies.

Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium (2024)
Journal Article
Cao, Z., Wong, F., Choudhury, A. K., Kamath, P. S., Topazian, M., Torre, A., Hayes, P. C., George, J., Idilman, R., Seto, W.-K., Desalegn, H., Alvares-da-Silva, M. R., Bush, B. J., Thacker, L. R., Xie, Q., & Bajaj, J. S. (2024). Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium. The Lancet Gastroenterology & Hepatology, 9(11), 997-1009. https://doi.org/10.1016/s2468-1253%2824%2900224-3

Background: Infections have a poor prognosis in inpatients with cirrhosis. We aimed to determine regional variations in infections and their association with clinical outcomes in a global cohort of inpatients with cirrhosis. Methods: In this prospect... Read More about Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium.