Outputs (633)

Exploring the acceptability of and adherence to prehabilitation and rehabilitation in patients undergoing major abdominal surgery: A systematic review and meta-analysis (2024)
Journal Article
Alsuwaylihi, A., Skořepa, P., Prado, C. M., Gomez, D., Lobo, D. N., & O'Connor, D. (2024). Exploring the acceptability of and adherence to prehabilitation and rehabilitation in patients undergoing major abdominal surgery: A systematic review and meta-analysis. Clinical Nutrition ESPEN, 63, 709-726. https://doi.org/10.1016/j.clnesp.2024.07.1060

Background and aims: Prehabilitation combines exercise, nutritional, and psychological interventions administered before surgery to improve patient outcomes. This comprehensive review and meta-analysis examined the feasibility, adherence, and effecti... Read More about Exploring the acceptability of and adherence to prehabilitation and rehabilitation in patients undergoing major abdominal surgery: A systematic review and meta-analysis.

Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs (2024)
Journal Article
Sayers, I., Thakker, D., Billington, C., Kreideweiss, S., Grundl, M. A., Bouyssou, T., Thamm, S., Kreuz, S., & Hall, I. P. (2024). Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs. British Journal of Pharmacology, 181(22), 4647-4657. https://doi.org/10.1111/bph.16509

Background and Purpose: Toll‐like receptors 4 (TLR4) and TLR7/TLR8 play an important role in mediating the inflammatory effects of bacterial and viral pathogens. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is an important regulator of signalli... Read More about Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs.

Does amino acid infusion improve kidney outcomes in patients at high risk for postsurgical AKI? (2024)
Journal Article
Faguer, S., Selby, N. M., Seigneux, S. D. E., Cantaluppi, V., Gameiro, J., Lopes, J. A., Malyszko, J., Belen Sanz, A., Saritas, T., & Ostermann, M. (2025). Does amino acid infusion improve kidney outcomes in patients at high risk for postsurgical AKI?. Nephrology Dialysis Transplantation, 40(3), 412-414. https://doi.org/10.1093/ndt/gfae183

The role of the ALKBH5 RNA demethylase in invasive breast cancer (2024)
Journal Article
Woodcock, C. L., Alsaleem, M., Toss, M. S., Lothion-Roy, J., Harris, A. E., Jeyapalan, J. N., Blatt, N., Rizvanov, A. A., Miftakhova, R. R., Kariri, Y. A., Madhusudan, S., Green, A. R., Rutland, C. S., Fray, R. G., Rakha, E. A., & Mongan, N. P. (2024). The role of the ALKBH5 RNA demethylase in invasive breast cancer. Discover Oncology, 15(1), Article 343. https://doi.org/10.1007/s12672-024-01205-8

Background: N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological mechanism... Read More about The role of the ALKBH5 RNA demethylase in invasive breast cancer.

Real-World Evidence of Omnipod® 5 Automated Insulin Delivery System Use in 69,902 People with Type 1 Diabetes (2024)
Journal Article
Forlenza, G. P., DeSalvo, D. J., Aleppo, G., Wilmot, E. G., Berget, C., Huyett, L. M., Hadjiyianni, I., Méndez, J. J., Conroy, L. R., Ly, T. T., & Sherr, J. L. (2024). Real-World Evidence of Omnipod® 5 Automated Insulin Delivery System Use in 69,902 People with Type 1 Diabetes. Diabetes Technology and Therapeutics, 26(8), 514-525. https://doi.org/10.1089/dia.2023.0578

Background:

The Omnipod® 5 Automated Insulin Delivery System was associated with favorable glycemic outcomes for people with type 1 diabetes (T1D) in two pivotal clinical trials. Real-world evidence is needed to explore effectiveness in nonstudy... Read More about Real-World Evidence of Omnipod® 5 Automated Insulin Delivery System Use in 69,902 People with Type 1 Diabetes.

Real‐world outcomes of patients with relapsed/refractory large B‐cell lymphoma receiving second‐line therapy in England (2024)
Journal Article
Fox, C. P., Townsend, W., Gribben, J. G., Menne, T., Kalakonda, N., Williams, P., Toron, F., Tyas, E., Cooper, M., Rickards, J., & Radford, J. (2024). Real‐world outcomes of patients with relapsed/refractory large B‐cell lymphoma receiving second‐line therapy in England. eJHaem, 5(5), 992-997. https://doi.org/10.1002/jha2.970

Autologous stem-cell transplantation (ASCT) is standard therapy for relapsed/refractory large B-cell lymphoma (R/R LBCL), but many patients are either ineligible or unable to receive it. This retrospective study characterized outcomes in R/R LBCL, de... Read More about Real‐world outcomes of patients with relapsed/refractory large B‐cell lymphoma receiving second‐line therapy in England.

Supramolecular hydrogels enable co-delivery of chemotherapeutics with synergistic efficacy against patient-derived glioblastoma cells and spheroids (2024)
Journal Article
Cavanagh, R. J., Baquain, S., Alexander, C., Scherman, O. A., & Rahman, R. (2024). Supramolecular hydrogels enable co-delivery of chemotherapeutics with synergistic efficacy against patient-derived glioblastoma cells and spheroids. RSC Advances, https://doi.org/10.1039/D4PM00177J

Drug combinations have been shown to be highly effective in many cancer therapies but the ratios of the individual drugs must be adjusted carefully and formulated appropriately to ensure synergistic action. Here we assessed combinations of doxorubici... Read More about Supramolecular hydrogels enable co-delivery of chemotherapeutics with synergistic efficacy against patient-derived glioblastoma cells and spheroids.

Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study. (2024)
Journal Article
Lamb, E. J., Barratt, J., Brettell, E. A., Cockwell, P., Dalton, R. N., Deeks, J. J., Eaglestone, G., Pellatt-Higgins, T., Kalra, P. A., Khunti, K., Loud, F. C., Ottridge, R. S., Potter, A., Rowe, C., Scandrett, K., Sitch, A. J., Stevens, P. E., Sharpe, C. C., Shinkins, B., Smith, A., …Taal, M. W. (2024). Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study. Health Technology Assessment, 28(35), 1-169. https://doi.org/10.3310/HYHN1078

Background: Estimation of glomerular filtration rate using equations based on creatinine is widely used to manage chronic kidney disease. In the UK, the Chronic Kidney Disease Epidemiology Collaboration creatinine equation is recommended. Other publi... Read More about Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study..

Challenges in Enhanced Recovery After Surgery (ERAS) research (2024)
Journal Article
Lobo, D. N., Joshi, G. P., & Kehlet, H. (2024). Challenges in Enhanced Recovery After Surgery (ERAS) research. British Journal of Anaesthesia, 133(4), 717-721. https://doi.org/10.1016/j.bja.2024.06.031

Despite the general agreement that implementation of Enhanced Recovery After Surgery (ERAS) pathways decrease hospital length of stay, a continuous challenge that has often been neglected is a procedure- and patient-specific approach. For example, as... Read More about Challenges in Enhanced Recovery After Surgery (ERAS) research.

Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility (2024)
Journal Article
Butt, M. F., Groen, J., Corsetti, M., Jonker, C. A., Burton‐Murray, H., Carrington, E. V., Chang, L., Di Lorenzo, C., Ellis, J., Escher, J. C., Gorter, R. R., Jewell, S., Karrento, K., Koster, E. C., Nurko, S., Rosen, R., van Tilburg, M. A., Zarate-Lopez, N., & Benninga, M. A. (2024). Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility. Neurogastroenterology and Motility, 36(10), Article e14869. https://doi.org/10.1111/nmo.14869

Transition services—programs that support adolescents and young adults (AYAs) as they move from a child‐centered to a more autonomous, adult‐orientated healthcare system—have been associated with improved short‐ and long‐term healthcare outcomes. Unf... Read More about Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility.