Skip to main content

Research Repository

Advanced Search

Outputs (33)

Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article
Stubbendorff, C., Hale, E., Bast, T., Cassaday, H. J., Martin, S. J., Suwansawang, S., …Stevenson, C. W. (2023). Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear. Scientific Reports, 13, Article 17631. https://doi.org/10.1038/s41598-023-44772-6

Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.

Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries (2023)
Journal Article
Cassaday, H. J., Cavenagh, L., Aluthgamage, H., Crooks, A., Bonardi, C., Stevenson, C. W., …Muir, C. (2023). Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries. PLoS ONE, 18(8), Article e0290232. https://doi.org/10.1371/journal.pone.0290232

Three groups of participants (largely recruited from the UK) completed a survey to examine attitudes to the use of animals in biomedical research, after reading the lay (N = 182) or technical (N = 201) summary of a research project, or no summary (N... Read More about Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries.

Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner (2023)
Journal Article
Stubbendorff, C., Hale, E., Day, H. L. L., Smith, J., Alvaro, G. S., Large, C. H., & Stevenson, C. W. (2023). Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 127, Article 110829. https://doi.org/10.1016/j.pnpbp.2023.110829

Various psychiatric diseases are characterized by aberrant cognition and emotional regulation. This includes inappropriately attributing affective salience to innocuous cues, which can be investigated using translationally relevant preclinical models... Read More about Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner.

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats (2022)
Journal Article
Warren, W. G., Papagianni, E. P., Hale, E., Brociek, R. A., Cassaday, H. J., & Stevenson, C. W. (2022). Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats. Frontiers in Pharmacology, 13, Article 1082760. https://doi.org/10.3389/fphar.2022.1082760

Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinct... Read More about Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats.

Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii (2022)
Journal Article
Fakae, L. B., Harun, M. S., Ting, D. S. J., Dua, H. S., Cave, G. W., Zhu, X. Q., …Elsheikha, H. M. (2023). Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii. Acta Tropica, 237, Article 106729. https://doi.org/10.1016/j.actatropica.2022.106729

We examined the anti-acanthamoebic efficacy of green tea Camellia sinensis solvent extract (SE) or its chemical constituents against Acanthamoeba castellanii by using anti-trophozoite, anti-encystation, and anti-excystation assays. C. sinensis SE (62... Read More about Camellia sinensis solvent extract, epigallocatechin gallate and caffeine confer trophocidal and cysticidal effects against Acanthamoeba castellanii.

Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance (2022)
Journal Article
Papagianni, E. P., Warren, W. G., Cassaday, H. J., & Stevenson, C. W. (2022). Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance. International Journal of Molecular Sciences, 23(16), Article 9333. https://doi.org/10.3390/ijms23169333

Cannabidiol, the main non-psychotropic constituent of cannabis, has potential as a treatment for anxiety-related disorders since it reduces learned fear expression and enhances fear extinction. The return of fear over time after successful extinction... Read More about Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance.

URB597 induces subtle changes to aggression in adult Lister Hooded rats (2022)
Journal Article
Warren, W. G., Hale, E., Papagianni, E. P., Cassaday, H. J., Stevenson, C. W., & Stubbendorff, C. (2022). URB597 induces subtle changes to aggression in adult Lister Hooded rats. Frontiers in Psychiatry, 13, Article 885146. https://doi.org/10.3389/fpsyt.2022.885146

The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on socia... Read More about URB597 induces subtle changes to aggression in adult Lister Hooded rats.

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures (2021)
Journal Article
Waite, L., Bonardi, C., Stevenson, C. W., & Cassaday, H. J. (2021). Strain comparisons in inhibitory discrimination learning and novel object recognition procedures. Physiology and Behavior, 240, Article 113557. https://doi.org/10.1016/j.physbeh.2021.113557

Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetiti... Read More about Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.

In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction (2021)
Journal Article
Warren, W. G., Papagianni, E. P., Stevenson, C. W., & Stubbendorff, C. (2022). In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction. European Journal of Neuroscience, 55(4), 952-970. https://doi.org/10.1111/ejn.15200

Anxiety and trauma-related disorders, such as post-traumatic stress disorder (PTSD), are debilitating mental illnesses with great personal and socioeconomic costs. Examining memory formation and relevant behavioural responding associated with aversiv... Read More about In it together? The case for endocannabinoid–noradrenergic interactions in fear extinction.