Outputs (128)

Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors (2020)
Journal Article
Zhu, H., Sun, H., Liu, Y., Duan, Y., Liu, J., Yang, X., …Xu, J. (2020). Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. European Journal of Medicinal Chemistry, 207, Article 112716. https://doi.org/10.1016/j.ejmech.2020.112716

A series of novel vinyl selenone derivatives were designed, synthesized and evaluated as the tubulin polymerization inhibitors using a bioisosteric strategy. Among them, the representative compound 11k exhibited satisfactory anti-proliferative activi... Read More about Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors.

Synthesis of Passerini-3CR Polymers and Assembly into Cytocompatible Polymersomes (2020)
Journal Article
Travanut, A., Monteiro, P. F., Oelmann, S., Howdle, S. M., Grabowska, A. M., Clarke, P. A., …Alexander, C. (2021). Synthesis of Passerini-3CR Polymers and Assembly into Cytocompatible Polymersomes. Macromolecular Rapid Communications, 42(6), Article 2000321. https://doi.org/10.1002/marc.202000321

© 2020 The Authors. Published by Wiley-VCH GmbH The versatility of the Passerini three component reaction (Passerini-3CR) is herein exploited for the synthesis of an amphiphilic diblock copolymer, which self-assembles into polymersomes. Carboxy-funct... Read More about Synthesis of Passerini-3CR Polymers and Assembly into Cytocompatible Polymersomes.

The Interplay Between Liver First-Pass Effect and Lymphatic Absorption of Cannabidiol and Its Implications for Cannabidiol Oral Formulations (2020)
Journal Article
Franco, V., Gershkovich, P., Perucca, E., & Bialer, M. (2020). The Interplay Between Liver First-Pass Effect and Lymphatic Absorption of Cannabidiol and Its Implications for Cannabidiol Oral Formulations. Clinical Pharmacokinetics, 59(12), 1493-1500. https://doi.org/10.1007/s40262-020-00931-w

For highly lipophilic drugs, passage into the intestinal lymphatic system rather than the portal vein following oral administration may represent a major alternative route of delivery into the general circulation. Increasing intestinal lymphatic tran... Read More about The Interplay Between Liver First-Pass Effect and Lymphatic Absorption of Cannabidiol and Its Implications for Cannabidiol Oral Formulations.

Use of an optofluidic microreactor and Cu nanoparticles synthesized in ionic liquid and embedded in TiO2 for an efficient photoreduction of CO2 to methanol (2020)
Journal Article
Albo, J., Qadir, M. I., Samperi, M., Alves Fernandes, J., de Pedro, I., & Dupont, J. (2021). Use of an optofluidic microreactor and Cu nanoparticles synthesized in ionic liquid and embedded in TiO2 for an efficient photoreduction of CO2 to methanol. Chemical Engineering Journal, 404, Article 126643. https://doi.org/10.1016/j.cej.2020.126643

Design and development of 3D hierarchical ultra-microporous CO2-sieving carbon architectures for potential flow-through CO2 capture at typical practical flue gas temperatures (2020)
Journal Article
Liu, X., Liu, J., Sun, C., Liu, H., Wang, W., Smith, E., …Snape, C. (2020). Design and development of 3D hierarchical ultra-microporous CO2-sieving carbon architectures for potential flow-through CO2 capture at typical practical flue gas temperatures. Journal of Materials Chemistry A, 8(33), 17025-17035. https://doi.org/10.1039/d0ta01417f

Developing effective carbon materials for post-combustion CO2 capture (PCC) has received great attentions over many recent years, owing to their desirable adsorption−desorption performance and exceptional thermo-oxidative stability compared to virtua... Read More about Design and development of 3D hierarchical ultra-microporous CO2-sieving carbon architectures for potential flow-through CO2 capture at typical practical flue gas temperatures.

Efficient Delivery of Transducing Polymer Nanoparticles for Gene-mediated Induction of Osteogenesis for Bone Regeneration (2020)
Journal Article
Jalal, A. R., & Dixon, J. E. (2020). Efficient Delivery of Transducing Polymer Nanoparticles for Gene-mediated Induction of Osteogenesis for Bone Regeneration. Frontiers in Bioengineering and Biotechnology, 8, https://doi.org/10.3389/fbioe.2020.00849

Developing non-viral gene therapy vectors that both protect and functionally deliver nucleic acid cargoes will be vital if gene augmentation and editing strategies are to be effectively combined with advanced regenerative medicine approaches. Current... Read More about Efficient Delivery of Transducing Polymer Nanoparticles for Gene-mediated Induction of Osteogenesis for Bone Regeneration.

Functionalized block co-polymer pro-drug nanoparticles with anti-cancer efficacy in 3D spheroids and in an orthotopic triple negative breast cancer model (2020)
Journal Article
Taresco, V., Abelha, T. F., Cavanagh, R. J., Vasey, C. E., Anane-Adjei, A. B., Pearce, A. K., …Alexander, C. (2021). Functionalized block co-polymer pro-drug nanoparticles with anti-cancer efficacy in 3D spheroids and in an orthotopic triple negative breast cancer model. Advanced Therapeutics, 4(1), Article 2000103. https://doi.org/10.1002/adtp.202000103

Amphiphilic block co-polymers composed of poly(ethylene glycol)-co-poly(lactide)-co-poly(2-((tert-butoxycarbonyl)amino)-3-propyl carbonate) (PEG-pLA-pTBPC) are synthesized in monomer ratios and arrangements to enable assembly into nanoparticles with... Read More about Functionalized block co-polymer pro-drug nanoparticles with anti-cancer efficacy in 3D spheroids and in an orthotopic triple negative breast cancer model.

Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus (2020)
Journal Article
Blower, I., Tong, C., Sun, X., Murray, E., Luckett, J., Chan, W., …Hill, P. (2020). Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus. Sensors, 20(15), 1-12. https://doi.org/10.3390/s20154305

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Gaussia luciferase (GLuc) is a secreted protein with significant potential for use as a reporter of gene expression in bacterial pathogenicity studies. To date there are relatively few example... Read More about Gaussia luciferase as a reporter for quorum sensing in staphylococcus aureus.

Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels (2020)
Journal Article
Redondo-Gómez, C., Padilla-Lopategui, S., Azevedo, H. S., & Mata, A. (2020). Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels. ACS Biomaterials Science and Engineering, 6(9), 4870–4880. https://doi.org/10.1021/acsbiomaterials.0c00549

A key feature in biomaterial design is the incorporation of bioactive signals into artificial constructs to stimulate tissue regeneration. Most currently used hydrogel cell culture systems depend on the covalent attachment of extracellular matrix (EC... Read More about Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels.

Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles (2020)
Other
Jain, A., Trindade, G., Hicks, J. M., Potts, J. C., Rahman, R., Hague, R., …Rawson, F. Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles

Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein orientation upon adsorpti... Read More about Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles.