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Outputs (16)

Reforming pharmaceutical education to enhance the global uptake of pharmacogenomics and personalized medicine (2012)
Journal Article
Dias, M. M., Depala, K., Ward, H. M., Ward, M. B., Sorich, M. J., Anderson, C., & McKinnon, R. A. (2012). Reforming pharmaceutical education to enhance the global uptake of pharmacogenomics and personalized medicine. Current Pharmacogenomics and Personalized Medicine, 10(3), 231 - 238. https://doi.org/10.2174/187569212802510058

Personalized medicine has been defined as the tailoring of medical treatment based on individual patient characteristics. In practice, personalized medicine generally involves the stratifying of patient populations based on biomarkers, most frequentl... Read More about Reforming pharmaceutical education to enhance the global uptake of pharmacogenomics and personalized medicine.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., Rose, F. R., Grundy, R. G., & Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION

Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Patient experiences of taking antidepressants for depression: A secondary qualitative analysis (2012)
Journal Article
Anderson, C., & Roy, T. (2013). Patient experiences of taking antidepressants for depression: A secondary qualitative analysis. Research in Social and Administrative Pharmacy, 9(6), 884-902. https://doi.org/10.1016/j.sapharm.2012.11.002

Background
Depression is one of the most commonly encountered mental health problems leading to significant morbidity and mortality and high medical and societal costs. Antidepressant prescribing in the UK has more than doubled in the last decade. T... Read More about Patient experiences of taking antidepressants for depression: A secondary qualitative analysis.

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces (2012)
Journal Article
Epa, V., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., Davies, M. C., Alexander, M. R., & Winkler, D. A. (2012). Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry, 39(22), https://doi.org/10.1039/C2JM34782B

Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly... Read More about Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C.-Y., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., Mei, Y., Bayston, R., Irvine, D. J., Langer, R., Anderson, D. G., Williams, P., Davies, M. C., & Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), 868-875. https://doi.org/10.1038/nbt.2316

Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.

Pharmacogenomics and personalised medicine: Consumer perspectives, lessons learned in Australia and beyond (2012)
Journal Article
Anderson, C., Ward, H., Corkindale, D., Ward, M. B., Sorich, M. J., & McKinnon, R. A. (2012). Pharmacogenomics and personalised medicine: Consumer perspectives, lessons learned in Australia and beyond. Current Pharmacogenomics and Personalized Medicine, 10(2), 170 - 177. https://doi.org/10.2174/187569212800626395

A decade after Francis Collins, then Director of the Human Genome Project, stated that: “Genetic prediction of individual risks of disease and responsiveness to drugs will reach the medical mainstream in the next decade or so” the uptake of therapeut... Read More about Pharmacogenomics and personalised medicine: Consumer perspectives, lessons learned in Australia and beyond.

Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications (2012)
Journal Article
Chau, D. Y., Brown, S. V., Mather, M. L., Hutter, V., Tint, N. L., Dua, H. S., Rose, F. R., & Ghaemmaghami, A. M. (2012). Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications. Biomedical Materials, 7(4), Article 045011. https://doi.org/10.1088/1748-6041/7/4/045011

The amniotic membrane (AM) is considered as a natural cell culture substrate and has occasionally been exploited in regenerative medicine especially for ocular surface reconstruction and dermal wound healing applications. However, its use is limited... Read More about Tissue transglutaminase (TG-2) modified amniotic membrane: A novel scaffold for biomedical applications.

Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction (2012)
Journal Article
Reddy, T. R., Li, C., Fischer, P. M., & Dekker, L. V. (2012). Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction. ChemMedChem, 7(8), https://doi.org/10.1002/cmdc.201200107

Protein interactions are increasingly appreciated as targets in small-molecule drug discovery. The interaction between the adapter protein S100A10 and its binding partner annexin A2 is a potentially important drug target. To obtain small-molecule sta... Read More about Three-dimensional pharmacophore design and biochemical screening identifies substituted 1,2,4-triazoles as inhibitors of the annexin A2-S100A10 protein interaction.