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Outputs (1450)

Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation (2025)
Journal Article
Wijayasiri, P., Astbury, S., Needham, G., Kaye, P., Bhat, M., Piccinini, A. M., & Aravinthan, A. D. (2025). Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation. Human Cell, 38, Article 70. https://doi.org/10.1007/s13577-025-01201-2

Accumulation of senescent hepatocytes is universal in chronic liver disease (CLD). This study investigates an association between hepatocyte senescence and hepatocellular carcinoma (HCC) and explores the therapeutic role of sirolimus. Background live... Read More about Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation.

Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice (2025)
Journal Article
Chrisp, R., Masterson, M., Pope, R., Roberts, C. J., Collins, H. M., Watson, D. J. G., O’Neil, D., Aagaard, K. M., Gibson, C. L., Heery, D. M., & Moran, P. M. (2025). Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice. Scientific Reports, 15(1), Article 8347. https://doi.org/10.1038/s41598-025-92938-1

NPAS2 (Neuronal PAS Domain Protein 2) is a component of the core circadian clock and the coordinated activity between central brain and peripheral liver clock proteins postulated to be instrumental for linking behaviour and metabolism. We investigate... Read More about Sex-specific attenuation of constant light-induced memory impairment and Clock gene expression in brain in hepatic Npas2 knockout mice.

Preparing pharmacists for disaster management and practice: protocol for a scoping review with a participatory approach (2025)
Journal Article
Lydon, E., Scahill, S. L., Arakawa, N., Cox, A., Schneider, C. R., & Hanning, S. M. (2025). Preparing pharmacists for disaster management and practice: protocol for a scoping review with a participatory approach. BMJ Open, 15(3), Article e093033. https://doi.org/10.1136/bmjopen-2024-093033

Introduction Emergency humanitarian situations can be caused by extreme weather events, natural disasters, civil conflicts, international wars, terrorism and pandemics, which threaten our health and compromise health systems worldwide. Pharmacists ar... Read More about Preparing pharmacists for disaster management and practice: protocol for a scoping review with a participatory approach.

Enzymatic Synthesis of Functional PEGylated Adipate Copolymers (2025)
Journal Article
Axioti, E., Dixon, E. G., Jepras, T., Tin He, F., Hartman, P. J. V., Hopkins, B., Di Bari, V., Suksiriworapong, J., Cuzzucoli Crucitti, V., Galantini, L., Francolini, I., Cavanagh, R. J., & Taresco, V. (2025). Enzymatic Synthesis of Functional PEGylated Adipate Copolymers. ChemPlusChem, https://doi.org/10.1002/cplu.202400668

Many new active pharmaceutical ingredients (APIs) demonstrate high hydrophobicity and low water-solubility issues. In this regard, polymeric nanoparticles (NPs) have been extensively used as drug delivery carriers for the encapsulation of such APIs.... Read More about Enzymatic Synthesis of Functional PEGylated Adipate Copolymers.

Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom (2025)
Journal Article
Wilson, L. E., Knaggs, R. D., Avery, A. J., Thornley, T., Moss, J., Baamer, R. M., & Boyd, M. J. (2025). Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom. PAIN Reports, 10(2), Article e1246. https://doi.org/10.1097/PR9.0000000000001246

Introduction:
Knowledge of the potential for harm and adverse effects from long-term opioid medicines has led to reduced prescribing in recent years. However, the number of patients receiving opioid prescriptions from primary care in England remains... Read More about Difficulties with prescribed opioids: a cross-sectional survey of primary care patients in England, United Kingdom.

A Comparison of the Mechanical Properties of ECM Components and Synthetic Self-Assembling Peptides (2025)
Journal Article
Hartley, A., Williams, P. M., & Mata, A. (2025). A Comparison of the Mechanical Properties of ECM Components and Synthetic Self-Assembling Peptides. Advanced Healthcare Materials, Article 2402385. https://doi.org/10.1002/adhm.202402385

The field of tissue engineering is increasingly moving away from a one-size-fits-all approach of simple synthetic homogeneous gels, and embracing more tailored designs to optimize cell function and differentiation for the organ of interest. Extracell... Read More about A Comparison of the Mechanical Properties of ECM Components and Synthetic Self-Assembling Peptides.

Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits (2025)
Journal Article
Ligorio, C., Tavasoli, E., Karaman-Jurukovska, N., Ittycheri, A., Kotowska, A. M., Khan, M. H., Scurr, D. J., Gupta, S. A., Moogan, L. V., Emmetsberger, J., Lu, F., German, G. K., Mammone, T., & Mata, A. (2025). Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits. ACS Applied Bio Materials, https://doi.org/10.1021/acsabm.4c01816

Self-assembling peptides (SAPs) represent a rich source of building blocks that interact with biological structures. For instance, cosmetic SAPs like Palmitoyl hexapeptide-12 have gained increasing interest for their anti-aging properties. However, t... Read More about Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits.

Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis (2025)
Journal Article
Mignone, V., Arruda, M., Kilpatrick, L., Moore, B., Woolard, J., Hill, S., & Goulding, J. (in press). Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis. Journal of Microscopy,

Primary human umbilical vein endothelial cells can grow as both a monolayer in culture and also as a capillary-like network making them an ideal model system in order to study vascular remodelling. Image-based analysis can allow assessment of cell mo... Read More about Quantitative analysis of human umbilical vein endothelial cell morphology and tubulogenesis.

Pentablock thermoresponsive hydrogels for chemotherapeutic delivery in a pancreatic cancer model (2025)
Journal Article
Elsherbeny, A., Bayraltutan, H., Gumus, N., McCrorie, P., Garcia-Sampedro, A., Parmar, S., Ritchie, A., Meakin, M., Oz, U. C., Rahman, R., Ashworth, J. C., Grabowska, A. M., Moloney, C., & Alexander, C. (2025). Pentablock thermoresponsive hydrogels for chemotherapeutic delivery in a pancreatic cancer model. Biomaterials Science, https://doi.org/10.1039/d4bm01629g

The design of biodegradable and thermoresponsive polymeric hydrogels with tuneable properties holds immense promise for localised and sustained drug delivery. In this study, we designed and synthesised a library of novel pentablock copolymers, incorp... Read More about Pentablock thermoresponsive hydrogels for chemotherapeutic delivery in a pancreatic cancer model.