Skip to main content

Research Repository

Advanced Search

Outputs (1234)

CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection (2023)
Journal Article
Burgess, H. M., Grande, R., Riccio, S., Dinesh, I., Winkler, G. S., Depledge, D. P., & Mohr, I. (2023). CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection. EMBO Reports, 24(12), Article e56327. https://doi.org/10.15252/embr.202256327

Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme. By performing a targeted loss-of... Read More about CCR4‐NOT differentially controls host versus virus poly(a)‐tail length and regulates HCMV infection.

Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries (2023)
Journal Article
Warne, G. R., Lim, M., Wilkinson, K., Hessel, V., Williams, P. M., & Fisk, I. D. (2023). Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries. Innovative Food Science and Emerging Technologies, 90, Article 103497. https://doi.org/10.1016/j.ifset.2023.103497

Cold plasma treatment is an emerging non-thermal food processing tool. This study aimed to identify how cold plasma can improve the aroma of a model space food system (freeze-dried strawberries) by mitigating freeze-drying aroma losses. Cold plasma s... Read More about Radiofrequency cold plasma – A novel tool for flavour modification in fresh and freeze-dried strawberries.

Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis (2023)
Journal Article
Zhu, W., Wu, H., He, C., Zhu, H., Yao, H., Cao, Y., …Xu, J. (2023). Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis. RSC Medicinal Chemistry, https://doi.org/10.1039/d3md00447c

Herein, a series of novel β-elemene hybrids with different types of hydrogen sulfide (H2S) donors was designed and synthesized for the first time. In addition, all compounds were tested for H2S release in phosphate buffer solution assay, among which... Read More about Discovery of novel β-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis.

Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat (2023)
Journal Article
Nguyen Quang Le, T., Robertson, K., Escribà-Gelonch, M., Marschner, P., Nghiep Tran, N., Williams, P. M., …Hessel, V. (2023). Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat. Green Chemistry, 25(22), 9422-9437. https://doi.org/10.1039/d3gc02859c

Highly soluble commercial phosphorus (P) fertilisers have been the most common form of P applied in agriculture for decades, but their releasing efficiency can be low because phosphate ions can easily bind with cations in the soil to form precipitate... Read More about Microflow synthesis of a formulation of phosphorus fertiliser to enhance the P content in soil and P uptake in wheat.

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing (2023)
Journal Article
Metwally, W. M., El-Habashy, S. E., El-Hosseiny, L. S., Essawy, M. M., Eltaher, H. M., El-Khordagui, L., & El-Khordagui, L. K. (2023). Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing. Biofabrication, 16(1), Article 015001. https://doi.org/10.1088/1758-5090/acfd60

There is a constant demand for novel materials/biomedical devices to accelerate the healing of hard-to-heal wounds. Herein, an innovative 3D-printed bioinspired construct was developed as an antibacterial/regenerative scaffold for diabetic wound heal... Read More about Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing.

High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation (2023)
Journal Article
Mohammed, B. M., Sun, M., Cheng, Q., Litvak, M., McCrae, K. R., Emsley, J., …Gailani, D. (2024). High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation. Journal of Thrombosis and Haemostasis, 22(1), 225-237. https://doi.org/10.1016/j.jtha.2023.09.027

Background: In plasma, high molecular weight kininogen (HK) is either free or bound to prekallikrein (PK) or factor (F) XI (FXI). During contact activation, HK is thought to anchor PK and FXI to surfaces, facilitating their conversion to the protease... Read More about High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation.

Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation (2023)
Journal Article
Zhao, Q., Pavanello, L., Bartlam, M., & Winkler, G. S. (2023). Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation. Frontiers in Genetics, 14, Article 1233842. https://doi.org/10.3389/fgene.2023.1233842

In eukaryotic cells, the synthesis, processing, and degradation of mRNA are important processes required for the accurate execution of gene expression programmes. Fully processed cytoplasmic mRNA is characterised by the presence of a 5′cap structure... Read More about Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation.

Self-assembled chitosan-sodium usnate drug delivery nanosystems: Synthesis, characterization, stability studies, in vitro cytotoxicity and in vivo biocompatibility against 143 B cells (2023)
Journal Article
Brugnoli, B., Mariano, A., Simonis, B., Bombelli, C., Sennato, S., Piozzi, A., …Francolini, I. (2023). Self-assembled chitosan-sodium usnate drug delivery nanosystems: Synthesis, characterization, stability studies, in vitro cytotoxicity and in vivo biocompatibility against 143 B cells. Carbohydrate Polymer Technologies and Applications, 6, Article 100373. https://doi.org/10.1016/j.carpta.2023.100373

Polymers are among the most studied materials as drug carriers, due to their tunable chemical structure and ability to self-assemble to give different types of nanostructures. In this study, chitosan (CS) nanoparticles (NPs) were investigated as carr... Read More about Self-assembled chitosan-sodium usnate drug delivery nanosystems: Synthesis, characterization, stability studies, in vitro cytotoxicity and in vivo biocompatibility against 143 B cells.

Watching ion-driven kinetics of ribozyme folding and misfolding caused by energetic and topological frustration one molecule at a time (2023)
Journal Article
Hori, N., & Thirumalai, D. (2023). Watching ion-driven kinetics of ribozyme folding and misfolding caused by energetic and topological frustration one molecule at a time. Nucleic Acids Research, 51(19), 10737-10751. https://doi.org/10.1093/nar/gkad755

Folding of ribozymes into well-defined tertiary structures usually requires divalent cations. How Mg2+ ions direct the folding kinetics has been a long-standing unsolved problem because experiments cannot detect the positions and dynamics of ions. To... Read More about Watching ion-driven kinetics of ribozyme folding and misfolding caused by energetic and topological frustration one molecule at a time.