Outputs (99)

Assessment of the cellular localisation of the annexin A2/S100A10 complex in human placenta (2018)
Journal Article
Seham, E.-A., & Lodewijk, D. (2018). Assessment of the cellular localisation of the annexin A2/S100A10 complex in human placenta. Journal of Molecular Histology, 49(5), 531-543. https://doi.org/10.1007/s10735-018-9791-2

The AnxA2/S100A10 complex has been implicated in various placental functions but although the localisation of these proteins individually has been studied, there is no information about the localisation of their complex in situ at the cellular level.... Read More about Assessment of the cellular localisation of the annexin A2/S100A10 complex in human placenta.

Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis (2018)
Journal Article
Mbanefo, E. C., Le, L., Pennington, L. F., Odegaard, J. I., Jardetzky, T. S., Alouffi, A., Falcone, F. H., & Hsieh, M. H. (2018). Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis. FASEB Journal, 32(8), 4408-4419. https://doi.org/10.1096/fj.201701415r

Chemotherapy-induced hemorrhagic cystitis (CHC) can be difficult to manage. Prior work suggests that IL-4 alleviates ifosfamide-induced hemorrhagic cystitis (IHC), but systemically administered IL-4 causes significant side effects. We hypothesized th... Read More about Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis.

The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1 (2018)
Journal Article
Pearson, R. J., Blake, D. G., Mezna, M., Fischer, P. M., Westwood, N. J., & McInnes, C. (2018). The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1. Cell Chemical Biology, 25(9), 1107-1116.e4. https://doi.org/10.1016/j.chembiol.2018.06.001

The polo kinase family are important oncology targets that act in regulating entry into and progression through mitosis. Structure-guided discovery of a new class of inhibitors of Polo-like kinase 1 (PLK1) catalytic activity that interact with Cys67... Read More about The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1.

Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation (2018)
Journal Article
Fainberg, H. P., Birtwistle, M., Alagal, R., Alhaddad, A., Pope, M., Davies, G., Woods, R., Castellanos, M., May, S. T., Ortori, C. A., Barrett, D. A., Perry, V., Wiens, F., Stahl, B., van der Beek, E., Sacks, H., Budge, H., & Symonds, M. E. (2018). Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation. Scientific Reports, 8(1), 1-11. https://doi.org/10.1038/s41598-018-27376-3

Brown adipose tissue (BAT) undergoes pronounced changes after birth coincident with the loss of the BAT-specifc uncoupling protein (UCP)1 and rapid fat growth. The extent to which this adaptation may vary between anatomical locations remains unknown,... Read More about Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation.

Polyionic tags as enhancers of protein solubility in recombinant protein expression (2018)
Journal Article
Paraskevopoulou, V., & Falcone, F. (2018). Polyionic tags as enhancers of protein solubility in recombinant protein expression. Microorganisms, 6(2), 47. https://doi.org/10.3390/microorganisms6020047

Since the introduction of recombinant protein expression in the second half of the 1970s, the growth of the biopharmaceutical field has been rapid and protein therapeutics has come to the foreground. Biophysical and structural characterisation of rec... Read More about Polyionic tags as enhancers of protein solubility in recombinant protein expression.

Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects (2016)
Journal Article
Kirby, G., White, L., Steck, R., Berner, A., Bogoevski, K., Qutachi, O., Jones, B., Saifzadeh, S., Hutmacher, D., Shakesheff, K., & Woodruff, M. (2016). Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects. Materials, 9(4), 259. https://doi.org/10.3390/ma9040259

Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I (2016)
Journal Article
Paduano, F., Marrelli, M., White, L. J., Shakesheff, K., & Tatullo, M. (2016). Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I. PLoS ONE, 11(2), 1-18. https://doi.org/10.1371/journal.pone.0148225

Objectives
The aim of this study was to evaluate the level of odontogenic
differentiation of dental pulp stem cells (DPSCs) on hydrogel scaffolds derived from bone extracellular matrix (bECM) in comparison to those seeded on collagen I (Col-I), on... Read More about Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I.

Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition (2016)
Journal Article
Sicilia, G., Davis, A. L., Spain, S. G., Magnusson, J. P., Boase, N. R., Thurecht, K. J., & Alexander, C. (2016). Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition. Polymer Chemistry, 7(12), 2180-2191. https://doi.org/10.1039/C5PY01883H

Polymer–DNA conjugates in which one nucleic acid strand contains fluorine-substituted nucleobases have been prepared and characterised. The efficacy of these novel 19F nucleic acid–polymer conjugates as sensitive and selective in vitro reporters of D... Read More about Synthesis of 19F nucleic acid–polymer conjugates as real-time MRI probes of biorecognition.

Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale (2015)
Journal Article
Torras, N., Agusil, J. P., Vázquez, P., Duch, M., Hernández-Pinto, A. M., Samitier, J., de la Rosa, E. J., Esteve, J., Suárez, T., Pérez-García, L., & Plaza, J. A. (2016). Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale. Advanced Materials, 28(7), 1449-1454. https://doi.org/10.1002/adma.201504164

© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A novel suspended planar-array chips technology is described, which effectively allows molecular multiplexing using a single suspended chip to analyze extraordinarily smal... Read More about Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale.

Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system (2015)
Journal Article
Inostroza-Brito, K. E., Collin, E., Siton-Mendelson, O., Smith, K. H., Monge-Marcet, A., Ferreira, D. S., Rodríguez, R. P., Alonso, M., Rodríguez-Cabello, J. C., Reis, R. L., Sagués, F., Botto, L., Bitton, R., Azevedo, H. S., & Mata, A. (2015). Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system. Nature Chemistry, 7(11), 897-904. https://doi.org/10.1038/nchem.2349