Outputs (102)

Discovery of peptide ligands targeting a specific ubiquitin-like domain– binding site in the deubiquitinase USP11 (2018)
Journal Article
Spiliotopoulos, A., Ferreras, L. B., Densham, R. M., Caulton, S. G., Maddison, B. C., Morris, J. R., Dixon, J. E., Gough, K. C., & Dreveny, I. (2019). Discovery of peptide ligands targeting a specific ubiquitin-like domain– binding site in the deubiquitinase USP11. Journal of Biological Chemistry, 294(2), 424-436. https://doi.org/10.1074/jbc.RA118.004469

© 2019 Spiliotopoulos et al. Published by The American Society for Biochemistry and Molecular Biology, Inc. Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular processes. Defined noncatalytic domains in USP... Read More about Discovery of peptide ligands targeting a specific ubiquitin-like domain– binding site in the deubiquitinase USP11.

The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2018)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., Giles, T. C., Emes, R., Hodgman, C., Parr, T., & Brameld, J. M. (2018). The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 8, Article 15915. https://doi.org/10.1038/s41598-018-34315-9

Synthetic beta-adrenergic agonists (BA) have broad biomedical and agricultural application for increasing lean body mass, yet a poor understanding of the biology underpinning these agents is limiting further drug discovery potential. Growing female p... Read More about The beta-adrenergic agonist, Ractopamine increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program.

Are nutraceuticals better than carprofen at controlling osteoarthritis in dogs? (2018)
Journal Article
Belshaw, Z., & Brennan, M. (2018). Are nutraceuticals better than carprofen at controlling osteoarthritis in dogs?. Veterinary Record, 183(16), 507-508. https://doi.org/10.1136/vr.k4486

Sally, a 12-year-old female neutered black Labrador, is presented to you with right forelimb lameness. She has decreased range of movement in both hips and the right elbow. You radiograph her hips, stifles, shoulders and elbows and find she has signi... Read More about Are nutraceuticals better than carprofen at controlling osteoarthritis in dogs?.

Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep (2018)
Journal Article
Mansbridge, N., Mitsch, J., Bollard, N., Ellis, K., Miguel-Pacheco, G. G., Dottorini, T., & Kaler, J. (2018). Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep. Sensors, 18(10), Article 3532. https://doi.org/10.3390/s18103532

Grazing and ruminating are the most important behaviours for ruminants, as they spend most of their daily time budget performing these. Continuous surveillance of eating behaviour is an important means for monitoring ruminant health, productivity and... Read More about Feature selection and comparison of machine learning algorithms in classification of grazing and rumination behaviour in sheep.

Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures (2018)
Journal Article
Cong, W., Dottorini, T., Khan, F., Emes, R. D., Zhang, F.-K., Zhou, C.-X., He, J.-J., Zhang, X.-X., Elsheikha, H. M., & Zhu, X.-Q. (2018). Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures. Frontiers in Immunology, 9, Article 2403. https://doi.org/10.3389/fimmu.2018.02403

RNA-sequencing was used to detect transcriptional changes in six tissues of cats, seven days after T. gondii infection. A total of 737 genes were differentially expressed (DEGs), of which 410 were up-regulated and 327 were down-regulated. The liver e... Read More about Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures.

Fasciola hepatica, TGF-β and host mimicry: the enemy within (2018)
Journal Article
Musah-Eroje, M., & Flynn, R. J. (2018). Fasciola hepatica, TGF-β and host mimicry: the enemy within. Current Opinion in Microbiology, 46, 80-85. https://doi.org/10.1016/j.mib.2018.09.002

Helminths parasites undergo developmental changes and migration within their definitive host, in addition to establishing chronic infection. Essential to this is the evasion of host immune responses; the canonical Th2 response is effective at removin... Read More about Fasciola hepatica, TGF-β and host mimicry: the enemy within.

Predicting puberty in partial androgen insensitivity syndrome: use of clinical and functional androgen receptor indices (2018)
Journal Article
Lek, N., Tadokoro-Cuccaro, R., Whitchurch, J. B., Mazumder, B., Miles, H., Prentice, P., Bunch, T., Zielińska, K., Metzler, V. M., Mongan, N. P., Heery, D. M., & Hughes, I. A. (2018). Predicting puberty in partial androgen insensitivity syndrome: use of clinical and functional androgen receptor indices. EBioMedicine, 36, 401-409. https://doi.org/10.1016/j.ebiom.2018.09.047

Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness (2018)
Journal Article
Rayneau-Kirkhope, D., Mao, Y., & Rauch, C. (2018). Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness. Physical Review Applied, 10(3), 1-10. https://doi.org/10.1103/PhysRevApplied.10.034016

Throughout biology, geometric hierarchy is a recurrent theme in structures where strength is achieved with efficient material usage. Acting over vast timescales, evolution has brought about beautiful solutions to problems of mechanics that are only n... Read More about Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness.

Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds (2018)
Journal Article
HUDSON, C., & GREEN, M. (2018). Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds. Journal of Dairy Science, 101(12), 11262-11274. https://doi.org/10.3168/jds.2017-13962

Milk constituent concentrations in samples taken during early lactation are often used to generate proxy measures for energy balance in dairy herds. This study aimed to explore associations between these and other measures routinely recorded by dairy... Read More about Associations between routinely collected dairy herd improvement data and insemination outcome in UK dairy herds.

Clinical audit in farm animal veterinary practice: Part 1: preparing for audit (2018)
Journal Article
Waine, K., Dean, R., Hudson, C., & Brennan, M. (2018). Clinical audit in farm animal veterinary practice: Part 1: preparing for audit. In Practice, 40(8), 360-364. https://doi.org/10.1136/inp.k3950

This article, the first in a two-part series providing practical advice for practitioners on carrying out clinical audits, discusses the preparation and initiation of clinical audit in farm animal practice. In the second article, to be published in a... Read More about Clinical audit in farm animal veterinary practice: Part 1: preparing for audit.