Outputs (27)

The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells (2020)
Journal Article
Stokes, S., Almire, F., Tatham, M. H., McFarlane, S., Mertens, P., Pondeville, E., & Boutell, C. (2020). The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells. PLoS Pathogens, 16(12), Article e1009134. https://doi.org/10.1371/journal.ppat.1009134

Mosquitoes are responsible for the transmission of many clinically important arboviruses that cause significant levels of annual mortality and socioeconomic health burden worldwide. Deciphering the mechanisms by which mosquitoes modulate arbovirus in... Read More about The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.

Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8 (2020)
Journal Article
Veronesi, E., Darpel, K., Gubbins, S., Batten, C., Nomikou, K., Mertens, P., & Carpenter, S. (2020). Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8. Microorganisms, 8(6), Article 851. https://doi.org/10.3390/microorganisms8060851

Bluetongue virus (BTV) causes an economically important disease, bluetongue (BT), in susceptible ruminants and is transmitted primarily by species of Culicoides biting midges (Diptera: Ceratopogonidae). Since 2006, northern Europe has experienced mul... Read More about Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8.

Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830) (2020)
Journal Article
Bell-Sakyi, L., Mohd Jaafar, F., Monsion, B., Luu, L., Denison, E., Carpenter, S., Attoui, H., & Mertens, P. P. C. (2020). Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830). Microorganisms, 8(6), Article 825. https://doi.org/10.3390/microorganisms8060825

Culicoides biting midges (Diptera: Ceratopogonidae) transmit arboviruses of veterinary or medical importance, including bluetongue virus (BTV) and Schmallenberg virus, as well as causing severe irritation to livestock and humans. Arthropod cell lines... Read More about Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830).

“Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence (2020)
Journal Article
Pascall, D. J., Nomikou, K., Bréard, E., Zientara, S., da Silva Filipe, A., Hoffmann, B., Jacquot, M., Singer, J. B., de Clercq, K., Bøtner, A., Sailleau, C., Viarouge, C., Batten, C., Puggioni, G., Ligios, C., Savini, G., van Rijn, P. A., Mertens, P. P. C., Biek, R., & Palmarini, M. (2020). “Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence. PLoS Biology, 18(4), Article e300067. https://doi.org/10.1371/journal.pbio.3000673

© 2020 Pascall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about “Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence.

Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot (2019)
Journal Article
Jacquot, M., Rao, P. P., Yadav, S., Nomikou, K., Maan, S., Jyothi, Y. K., Reddy, N., Putty, K., Hemadri, D., Singh, K. P., Maan, N. S., Hegde, N. R., Mertens, P., & Biek, R. (2019). Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot. Virus Evolution, 5(2), Article vez027. https://doi.org/10.1093/ve/vez027

For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes,... Read More about Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot.

Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice (2019)
Journal Article
Fay, P. C., Attoui, H., Batten, C., Mohd Jaafar, F., Lomonossoff, G. P., Daly, J. M., & Mertens, P. P. (2019). Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice. Vaccine, 2, Article 100026. https://doi.org/10.1016/j.jvacx.2019.100026

Bluetongue is a severe, economically important disease of ruminants that is widely distributed in tropical and temperate regions around the world. It is associated with major production losses, restrictions of animal movements and trade, as well as c... Read More about Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice.

A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host (2019)
Journal Article
Stevens, L. M., Moffat, K., Cooke, L., Nomikou, K., Mertens, P. P. C., Jackson, T., & Darpel, K. E. (2019). A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host. Journal of General Virology, 100(4), 568-582. https://doi.org/10.1099/jgv.0.001240

Bluetongue virus (BTV) causes an economically important disease in domestic and wildlife ruminants and is transmitted by Culicoides biting midges. In ruminants, BTV has a wide cell tropism that includes endothelial cells of vascular and lymphatic ves... Read More about A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host.

The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host (2018)
Journal Article
Calvo-Pinilla, E., Gubbins, S., Mertens, P. P., Ortego, J., & Castillo-Olivares, J. (2018). The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host. Antiviral Research, 154, https://doi.org/10.1016/j.antiviral.2018.04.015

African horse sickness (AHS) is a lethal equine disease transmitted by Culicoides biting midges and caused by African horse sickness virus (AHSV). AHS is endemic to sub-Saharan Africa, but devastating outbreaks have been recorded periodically outside... Read More about The immunogenicity of recombinant vaccines based on modified Vaccinia Ankara (MVA) viruses expressing African horse sickness virus VP2 antigens depends on the levels of expressed VP2 protein delivered to the host.

Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India (2017)
Journal Article
Reddy, Y. V., Susmitha, B., Patil, S., Krishnajyothi, Y., Putty, K., Ramakrishna, K., Sunitha, G., Devi, B., Kavitha, K., Deepthi, B., Krovvidi, S., Reddy, Y., Reddy, G. H., Singh, K., Maan, N. S., Hemadri, D., Maan, S., Mertens, P., Hegde, N., & Rao, P. (in press). Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India. Transboundary and Emerging Diseases, https://doi.org/10.1111/tbed.12738

Bluetongue (BT) is a Culicoides-borne disease caused by several serotypes of bluetongue virus (BTV). Similar to other insect-borne viral diseases, distribution of BT is limited to distribution of Culicoides species competent to transmit BTV. In the t... Read More about Isolation and evolutionary analysis of Australasian topotype of bluetongue virus serotype 4 from India.

Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference (2017)
Journal Article
Jacquot, M., Nomikou, K., Palmarini, M., Mertens, P., & Biek, R. (2017). Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference. Proceedings of the Royal Society B: Biological Sciences, 284(1864), Article 20170919. https://doi.org/10.1098/rspb.2017.0919

Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as... Read More about Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference.