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Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference

Jacquot, Maude; Nomikou, Kyriaki; Palmarini, Massimo; Mertens, Peter; Biek, Roman

Authors

Maude Jacquot

Kyriaki Nomikou

Massimo Palmarini

Peter Mertens

Roman Biek



Abstract

Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and serotypes. Diffusion models using continuous space revealed that terrestrial habitat below 300 m altitude, wind direction and higher livestock densities were associated with faster BTV movement. Results of discrete phylogeographic analysis involving generalized linear models broadly supported these findings, but varied considerably with the level of spatial partitioning. Contrary to common perception, we found no evidence for average temperature having a positive effect on BTV diffusion, though both methodological and biological reasons could be responsible for this result. Our study provides important insights into the drivers of BTV transmission at the landscape scale that could inform predictive models of viral spread and have implications for designing control strategies.

Journal Article Type Article
Publication Date Oct 11, 2017
Journal Proceedings of the Royal Society B: Biological Sciences
Print ISSN 0962-8452
Electronic ISSN 1471-2954
Publisher Royal Society, The
Peer Reviewed Peer Reviewed
Volume 284
Issue 1864
Article Number 20170919
APA6 Citation Jacquot, M., Nomikou, K., Palmarini, M., Mertens, P., & Biek, R. (2017). Bluetongue virus spread in Europe is a consequence of climatic, landscape and vertebrate host factors as revealed by phylogeographic inference. Proceedings of the Royal Society B: Biological Sciences, 284(1864), https://doi.org/10.1098/rspb.2017.0919
DOI https://doi.org/10.1098/rspb.2017.0919
Keywords bluetongue, phylogeography, viral diffusion, environmental drivers, predictor testing, vector-borne pathogen
Publisher URL http://rspb.royalsocietypublishing.org/content/284/1864/20170919
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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