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Outputs (139)

“Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence (2020)
Journal Article
Pascall, D. J., Nomikou, K., Bréard, E., Zientara, S., da Silva Filipe, A., Hoffmann, B., …Palmarini, M. (2020). “Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence. PLoS Biology, 18(4), Article e300067. https://doi.org/10.1371/journal.pbio.3000673

© 2020 Pascall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about “Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence.

Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii (2020)
Journal Article
Nie, L., Liang, Q., Du, R., Elsheikha, H. M., Han, N., Li, F., & Zhu, X. (2020). Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii. Frontiers in Microbiology, 11, Article 776. https://doi.org/10.3389/fmicb.2020.00776

Lysine malonylation (Kmal) is a new post-translational modification (PTM), which has been reported in several prokaryotic and eukaryotic species. Although Kmal can regulate many and diverse biological processes in various organisms, knowledge about t... Read More about Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii.

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury (2020)
Journal Article
Kim, J. Y., Bai, Y., Jayne, L. A., Hector, R. D., Persaud, A. K., Ong, S. S., …Pabla, N. S. (2020). A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. Nature Communications, 11(1), Article 1924. https://doi.org/10.1038/s41467-020-15638-6

© 2020, The Author(s). Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, elect... Read More about A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening (2020)
Journal Article
Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Cell Culture Based in vitro Test Systems for Anticancer Drug Screening. Frontiers in Bioengineering and Biotechnology, 8, Article 322. https://doi.org/10.3389/fbioe.2020.00322

The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of t... Read More about Cell Culture Based in vitro Test Systems for Anticancer Drug Screening.

Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018) (2020)
Journal Article
Mullins, R. A., Sanchez Villamil, C., Selmic, L. E., Tivers, M. S., Case, J. B., Singh, A., …Kirby, B. M. (2020). Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018). Veterinary Surgery, 49(5), 958-970. https://doi.org/10.1111/vsu.13422

© 2020 The American College of Veterinary Surgeons Objective: To identify prognostic factors for short-term survival of dogs that experience seizures within 7 days after surgical correction of single congenital extrahepatic portosystemic shunts (cEHP... Read More about Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018).

Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species (2020)
Journal Article
Chappell, J. G., Tsoleridis, T., Onianwa, O., Drake, G., Ashpole, I., Dobbs, P., …McClure, C. P. (2020). Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species. Viruses, 12(4), Article 454. https://doi.org/10.3390/v12040454

©2020 by the authors. Licensee MDPI, Basel, Switzerland. Orthohantaviruses are globally distributed viruses, associated with rodents and other small mammals. However, data on the circulation of orthohantaviruses within the UK, particularly the UK-end... Read More about Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports Its Classification as a Novel Species.

iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine (2020)
Journal Article
He, J., Ma, J., Wang, J., Zhang, F., Li, J., Zhai, B., …Zhu, X. (2020). iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine. Microorganisms, 8(4), Article 518. https://doi.org/10.3390/microorganisms8040518

Toxoplasma gondii is a leading cause of foodborne illness and consumption of undercooked pig meat is a major risk factor for acquiring toxoplasmosis, which causes a substantial burden on society. Here, we used isobaric tags for relative and absolute... Read More about iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine.

Influencing Change: When “Best Practice” Changes and the Prototypical Good Farmer Turns Bad (2020)
Journal Article
Green, L., Kaler, J., Liu, N., & Ferguson, E. (2020). Influencing Change: When “Best Practice” Changes and the Prototypical Good Farmer Turns Bad. Frontiers in Veterinary Science, 7, Article 161. https://doi.org/10.3389/fvets.2020.00161

Twenty-nine farmers with a flock prevalence of lameness >5% were visited in 2013. They participated in a facilitated discussion on treatment of footrot, and evidence-based new “best practice.” One year later, farmers were revisited and management and... Read More about Influencing Change: When “Best Practice” Changes and the Prototypical Good Farmer Turns Bad.

Crystal structure of the C-terminal domain of DENR (2020)
Journal Article
Lomakin, I. B., De, S., Wang, J., Borkar, A. N., & Steitz, T. A. (2020). Crystal structure of the C-terminal domain of DENR. Computational and Structural Biotechnology Journal, 18, 696-704. https://doi.org/10.1016/j.csbj.2020.03.009

© 2020 The Authors The density regulated protein (DENR) forms a stable heterodimer with malignant T-cell-amplified sequence 1 (MCT-1). DENR-MCT-1 heterodimer then participates in regulation of non-canonical translation initiation and ribosomal recycl... Read More about Crystal structure of the C-terminal domain of DENR.