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Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018)

Mullins, Ronan A.; Sanchez Villamil, Carlos; Selmic, Laura E.; Tivers, Mickey S.; Case, J. Brad; Singh, Ameet; Thieman Mankin, Kelley M.; Anderson, Davina; White, Robert N.; Pratschke, Kathryn M.; de Rooster, Hilde; Kummeling, Anne; Yool, Donald A.; Olive, Melanie; Billet, Jean-Philippe; Gordo, Ines; Brissot, Herve; Broome, Cameron; Kirby, Barbara M.

Authors

Ronan A. Mullins

Carlos Sanchez Villamil

Laura E. Selmic

Mickey S. Tivers

J. Brad Case

Ameet Singh

Kelley M. Thieman Mankin

Davina Anderson

ROB WHITE Rob.White@nottingham.ac.uk
Professor of Practice

Kathryn M. Pratschke

Hilde de Rooster

Anne Kummeling

Donald A. Yool

Melanie Olive

Jean-Philippe Billet

Ines Gordo

Herve Brissot

Cameron Broome

Barbara M. Kirby



Abstract

© 2020 The American College of Veterinary Surgeons Objective: To identify prognostic factors for short-term survival of dogs that experience seizures within 7 days after surgical correction of single congenital extrahepatic portosystemic shunts (cEHPSS). Study design: Multi-institutional retrospective study. Sample population: Ninety-three client-owned dogs. Methods: Medical records at 14 veterinary institutions were reviewed to identify dogs that underwent surgical attenuation of a single cEHPSS from January 1, 2005 through February 28, 2018 and experienced postattenuation seizures (PAS) within 7 days postoperatively. Logistic regression analysis was performed to identify factors associated with 1-month survival. Factors investigated included participating institution, signalment, shunt morphology, concurrent/historical conditions, presence of preoperative neurologic signs, presence of preoperative seizures, aspects of preoperative medical management, surgical details including method and degree of shunt attenuation, type of PAS (focal only or generalized ± focal), drugs administered as part of the treatment of PAS, and development of complications during treatment of PAS. Results: Thirty (32.3%) dogs survived to 30 days. Seventy-six (81.7%) dogs experienced generalized PAS. Factors positively associated with short-term survival included having a history of preoperative seizures (P =.004) and development of focal PAS only (P =.0003). Most nonsurvivors were humanely euthanized because of uncontrolled or recurrent seizures. Conclusion: Dogs that experienced PAS that had a history of preoperative seizures and those that experienced focal PAS only had significantly improved short-term survival. Clinical significance: The results of this study provide information that will help in the counseling of owners who seek treatment for PAS after surgical correction of cEHPSS. © 2020 The American College of Veterinary Surgeons.

Journal Article Type Article
Publication Date Jul 1, 2020
Journal Veterinary Surgery
Print ISSN 0161-3499
Electronic ISSN 1532-950X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 49
Issue 5
Pages 958-970
APA6 Citation Mullins, R. A., Sanchez Villamil, C., Selmic, L. E., Tivers, M. S., Case, J. B., Singh, A., …Kirby, B. M. (2020). Prognostic factors for short‐term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005‐2018). Veterinary Surgery, 49(5), 958-970. https://doi.org/10.1111/vsu.13422
DOI https://doi.org/10.1111/vsu.13422
Keywords General Veterinary
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1111/vsu.13422
Additional Information Received: 2018-10-02; Accepted: 2019-01-26; Published: 2020-04-04
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