Outputs (25)

Acetylome analysis of the feline small intestine following Toxoplasma gondii infection (2020)
Journal Article
Meng, Y., Zhai, B., Elsheikha, H. M., Xie, S., Wang, Z., Zhao, Q., …He, J. (2020). Acetylome analysis of the feline small intestine following Toxoplasma gondii infection. Parasitology Research, 119(11), 3649-3657. https://doi.org/10.1007/s00436-020-06880-4

Toxoplasma gondii is a protozoan parasite capable of infecting a large number of warm-blooded animals and causes serious health complications in immunocompromised patients. T. gondii infection of the feline small intestine is critical for the complet... Read More about Acetylome analysis of the feline small intestine following Toxoplasma gondii infection.

In Vitro Growth- and Encystation-Inhibitory Efficacies of Matcha Green Tea and Epigallocatechin Gallate Against Acanthameoba Castellanii (2020)
Journal Article
Dickson, A., Cooper, E., Fakae, L. B., Wang, B., Chan, K. L. A., & Elsheikha, H. M. (2020). In Vitro Growth- and Encystation-Inhibitory Efficacies of Matcha Green Tea and Epigallocatechin Gallate Against Acanthameoba Castellanii. Pathogens, 9(9), Article 763. https://doi.org/10.3390/pathogens9090763

We examined the inhibitory effect of matcha green tea (Camellia sinensis) and epigallocatechin gallate (EGCg; the most abundant catechin in tea) on the vegetative growth and encystation of Acanthamoeba castellanii T4 genotype. The sulforhodamine B (S... Read More about In Vitro Growth- and Encystation-Inhibitory Efficacies of Matcha Green Tea and Epigallocatechin Gallate Against Acanthameoba Castellanii.

Nematocidal effects of a coriander essential oil and five pure principles on the infective larvae of major ovine gastrointestinal nematodes in vitro (2020)
Journal Article
Helal, M. A., Abdel-Gawad, A. M., Kandil, O. M., Khalifa, M. M. E., Cave, G. W. V., Morrison, A. A., …Elsheikha, H. M. (2020). Nematocidal effects of a coriander essential oil and five pure principles on the infective larvae of major ovine gastrointestinal nematodes in vitro. Pathogens, 9(9), 1-17. https://doi.org/10.3390/pathogens9090740

The anthelmintic effects of extracted coriander oil and five pure essential oil constituents (geraniol, geranyl acetate, eugenol, methyl iso-eugenol, and linalool) were tested, using larval motility assay, on the third-stage larvae (L3s) of Haemonchu... Read More about Nematocidal effects of a coriander essential oil and five pure principles on the infective larvae of major ovine gastrointestinal nematodes in vitro.

Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro (2020)
Journal Article
Al-Sandaqchi, A. T., Marsh, V., Williams, H. E. L., Stevenson, C. W., & Elsheikha, H. M. (2020). Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro. Microorganisms, 8(9), Article 1386. https://doi.org/10.3390/microorganisms8091386

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Toxoplasma gondii (T. gondii), the causative agent of toxoplasmosis, is a frequent cause of brain infection. Despite its known ability to invade the brain, there is still a dire need to better... Read More about Structural, functional, and metabolic alterations in human cerebrovascular endothelial cells during toxoplasma gondii infection and amelioration by verapamil in vitro.

Effects of Toxoplasma gondii infection on the function and integrity of human cerebrovascular endothelial cells and the influence of Verapamil treatment in vitro (2020)
Journal Article
Harun, M., Marsh, V., Elsaied, N. A., Webb, K. F., & Elsheikha, H. M. (2020). Effects of Toxoplasma gondii infection on the function and integrity of human cerebrovascular endothelial cells and the influence of Verapamil treatment in vitro. Brain Research, 1746, Article 147002. https://doi.org/10.1016/j.brainres.2020.147002

Toxoplasma gondii can cause parasitic encephalitis, a life-threatening infection that predominately occurs in immunocompromised individuals. T. gondii has the ability to invade the brain, but the mechanisms by which this parasite crosses the blood–br... Read More about Effects of Toxoplasma gondii infection on the function and integrity of human cerebrovascular endothelial cells and the influence of Verapamil treatment in vitro.

In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii (2020)
Journal Article
Fakae, L. B., Stevenson, C. W., Zhu, X. Q., & Elsheikha, H. M. (2020). In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii. International Journal for Parasitology: Drugs and Drug Resistance, 13, 59-72. https://doi.org/10.1016/j.ijpddr.2020.05.001

© 2020 The Author(s) The effect of Camellia sinensis (green tea) on the growth of Acanthamoeba castellanii trophozoites was examined using a microplate based-Sulforhodamine B (SRB) assay. C. sinensis hot and cold brews at 75% and 100% concentrations... Read More about In vitro activity of Camellia sinensis (green tea) against trophozoites and cysts of Acanthamoeba castellanii.

Immunostimulatory efficacy and protective potential of putative TgERK7 protein in mice experimentally infected by Toxoplasma gondii (2020)
Journal Article
Li, Z. Y., Guo, H. T., Calderón-Mantilla, G., He, J. J., Wang, J. L., Bonev, B. B., …Elsheikha, H. M. (2020). Immunostimulatory efficacy and protective potential of putative TgERK7 protein in mice experimentally infected by Toxoplasma gondii. International Journal of Medical Microbiology, 310(5), https://doi.org/10.1016/j.ijmm.2020.151432

© 2020 The Author(s) The extracellular signal-regulated kinases (ERKs) serve as important determinants of cellular signal transduction pathways, and hence may play important roles during infections. Previous work suggested that putative ERK7 of Toxop... Read More about Immunostimulatory efficacy and protective potential of putative TgERK7 protein in mice experimentally infected by Toxoplasma gondii.

Drug discovery against acanthamoeba infections: Present knowledge and unmet needs (2020)
Journal Article
Elsheikha, H. M., Siddiqui, R., & Khan, N. A. (2020). Drug discovery against acanthamoeba infections: Present knowledge and unmet needs. Pathogens, 9(5), Article 405. https://doi.org/10.3390/pathogens9050405

Although major strides have been made in developing and testing various antiacanthamoebic drugs, recurrent infections, inadequate treatment outcomes, health complications, and side effects associated with the use of currently available drugs necessit... Read More about Drug discovery against acanthamoeba infections: Present knowledge and unmet needs.

Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii (2020)
Journal Article
Nie, L., Liang, Q., Du, R., Elsheikha, H. M., Han, N., Li, F., & Zhu, X. (2020). Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii. Frontiers in Microbiology, 11, Article 776. https://doi.org/10.3389/fmicb.2020.00776

Lysine malonylation (Kmal) is a new post-translational modification (PTM), which has been reported in several prokaryotic and eukaryotic species. Although Kmal can regulate many and diverse biological processes in various organisms, knowledge about t... Read More about Global Proteomic Analysis of Lysine Malonylation in Toxoplasma gondii.

iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine (2020)
Journal Article
He, J., Ma, J., Wang, J., Zhang, F., Li, J., Zhai, B., …Zhu, X. (2020). iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine. Microorganisms, 8(4), Article 518. https://doi.org/10.3390/microorganisms8040518

Toxoplasma gondii is a leading cause of foodborne illness and consumption of undercooked pig meat is a major risk factor for acquiring toxoplasmosis, which causes a substantial burden on society. Here, we used isobaric tags for relative and absolute... Read More about iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during toxoplasma gondii infection in swine.