Transcriptomics using lung resection material to advance our understanding of COPD and IPF pathogenesis
(2024)
Journal Article
Rakkar, K., Thakkar, D., A Portelli, M., Hall, I., Schlüter, H., & Sayers, I. (2024). Transcriptomics using lung resection material to advance our understanding of COPD and IPF pathogenesis. ERJ Open Research, https://doi.org/10.1183/23120541.00061-2024
Outputs (13)
Human bronchial epithelial cells from patients with asthma have an altered gene expression profile (2022)
Journal Article
Bhaker, S., Portelli, M. A., Rakkar, K., Shaw, D., Johnson, S., Brightling, C., & Sayers, I. (2022). Human bronchial epithelial cells from patients with asthma have an altered gene expression profile. ERJ Open Research, 8(1), Article 0625-2021. https://doi.org/10.1183/23120541.00625-2021Published21February2022
Phenotypic and functional translation of IL33 genetics in asthma (2020)
Journal Article
Ketelaar, M. E., Portelli, M. A., Dijk, F. N., Shrine, N., Faiz, A., Vermeulen, C. J., …Nawijn, M. C. (2021). Phenotypic and functional translation of IL33 genetics in asthma. Journal of Allergy and Clinical Immunology, 147(1), 144-157. https://doi.org/10.1016/j.jaci.2020.04.051© 2020 Background: Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms (SNPs) have been reproducibly associated with asthma. IL33 levels are elevate... Read More about Phenotypic and functional translation of IL33 genetics in asthma.
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium (2020)
Journal Article
Portelli, M. A., Dijk, F. N., Ketelaar, M. E., Shrine, N., Hankinson, J., Bhaker, S., …Sayers, I. (2020). Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. JCI insight, 5(8), Article 132446. https://doi.org/10.1172/jci.insight.132446The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the functional mechanisms underlying these associations remain to be def... Read More about Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium.
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets (2017)
Journal Article
Wain, L. V., Shrine, N., Artigas, M. S., Erzurumluoglu, A. M., Noyvert, B., Bossini-Castillo, L., …Hall, I. P. (2017). Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nature Genetics, 49(3), 416-425. https://doi.org/10.1038/ng.3787Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function dist... Read More about Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
Genome-wide association studies in asthma (2016)
Journal Article
Portelli, M. A., & Sayers, I. (in press). Genome-wide association studies in asthma. https://doi.org/10.1002/9780470015902.a0024639Asthma is a complex respiratory disease, with both genetic and environmental factors contributing to disease susceptibility. Genome-wide association studies (GWAS) have now identified novel risk alleles and loci associated with asthma diagnosis and m... Read More about Genome-wide association studies in asthma.
Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identi?es a severe, nonatopic subset of patients (2016)
Journal Article
Portelli, M. A., Moseley, C., Stewart, C. E., Postma, D. S., Howarth, P., Warner, J., …Sayers, I. (in press). Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients. Allergy, https://doi.org/10.1111/all.13046Rationale: Genetic polymorphisms in the asthma susceptibility gene, urokinase plasminogen activator receptor (uPAR/PLAUR) have been associated with lung function decline and uPAR blood levels in asthma subjects. Preliminary studieshave identi?ed uPAR... Read More about Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identi?es a severe, nonatopic subset of patients.
Erratum: Letters to the editor: Genetic polymorphism and soluble urokinase plasminogen activator receptor (2016)
Journal Article
Sayers, I., Portelli, M. A., & Siedlinski, M. (2016). Erratum: Letters to the editor: Genetic polymorphism and soluble urokinase plasminogen activator receptor. FASEB Journal, 30(6), 2451. https://doi.org/10.1096/fj.15-1201LTERERR
Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma (2016)
Journal Article
Ierodiakonou, D., Portelli, M. A., Postma, D. S., Koppelman, G. H., Gerritsen, J., ten Hacken, N. H., …Sayers, I. (2016). Urokinase plasminogen activator receptor polymorphisms and airway remodelling in asthma. European Respiratory Journal, 47(5), https://doi.org/10.1183/13993003.01571-2015
Response (2015)
Journal Article
Sayers, I., Portelli, M. A., & Siedlinski, M. (2015). Response. FASEB Journal, 29(12), https://doi.org/10.1096/fj.15-1201LTERWe thank Dr. Rasmussen and colleagues for their comments on our work outlined in “Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels” (FASEB J. 28, 923–934) and the opportunity to... Read More about Response.