Skip to main content

Research Repository

Advanced Search

Genome-wide association studies in asthma

Portelli, Michael A.; Sayers, Ian

Genome-wide association studies in asthma Thumbnail


Authors



Abstract

Asthma is a complex respiratory disease, with both genetic and environmental factors contributing to disease susceptibility. Genome-wide association studies (GWAS) have now identified novel risk alleles and loci associated with asthma diagnosis and more recently with clinical subgroups of disease. However, while providing insight into potential disease mechanisms these risk alleles have modest effect sizes and account for a small proportion of the anticipated heritability of asthma. In this article we provide an overview of GWAS in asthma to date including reproducible associations and advances in our understanding of the biology of asthma. In addition we discuss ancestry-specific findings and how genetics may contribute to the development of multiple allergic conditions known as the ‘atopic march’. Finally, we outline the strengths and weaknesses of GWAS and look to future approaches including a greater focus to functional variation and assessment of gene–gene and gene–environment interactions.

Journal Article Type Article
Acceptance Date Jul 5, 2016
Online Publication Date Nov 3, 2016
Deposit Date Mar 29, 2017
Publicly Available Date Mar 29, 2017
Journal eLS
Publisher Wiley
Peer Reviewed Peer Reviewed
Book Title eLS
DOI https://doi.org/10.1002/9780470015902.a0024639
Keywords Asthma; Genome-wide association study; Single nucleotide polymorphism; Heritability; Atopic march
Public URL https://nottingham-repository.worktribe.com/output/830214
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0024639/full
Additional Information This is the peer reviewed version of the following article: Portelli, M. and Sayers, I. 2016. Genome-Wide Association Studies in Asthma. eLS. 1–10. which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0024639/full This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Files





You might also like



Downloadable Citations