Outputs (829)

Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis (2019)
Journal Article
Farooqi, A., Khunti, K., Abner, S. C., Gillies, C., Morriss, R., & Seidu, S. (2019). Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice, 156, Article 107816. https://doi.org/10.1016/j.diabres.2019.107816

Objective: To examine the association of comorbid occurrence of diabetes and depression with risk of cardiovascular endpoints including cardiovascular mortality, coronary heart disease and stroke.

Research Design and Methods: A systematic review... Read More about Comorbid depression and risk of cardiac events and cardiac mortality in people with diabetes: A systematic review and meta-analysis.

Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments (2019)
Journal Article
Phan, H., Minut, R. I., McCrorie, P., Vasey, C., Larder, R. R., Krumins, E., Marlow, M., Rahman, R., Alexander, C., Taresco, V., & Pearce, A. K. (2019). Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments. Journal of Polymer Science Part A: Polymer Chemistry, 57(17), 1801-1810. https://doi.org/10.1002/pola.29451

The production of well-defined and reproducible poly-meric nanoparticles (NPs), in terms of size and stability in biological environments, is undoubtedly a fundamental challenge in the formulation of novel and more effective nanomedicines. The adopti... Read More about Role of Self‐Assembly Conditions and Amphiphilic Balance on Nanoparticle Formation of PEG‐PDLLA Copolymers in Aqueous Environments.

Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT (2019)
Journal Article
Gilleece, M. H., Labopin, M., Savani, B. N., Yakoub-Agha, I., Socié, G., Gedde-Dahl, T., Blaise, D., Byrne, J. L., Craddock, C., Cornelissen, J. L., Arcese, W., Forcade, E., Crawley, C., Polge, E., Mohty, M., & Nagler, A. (2019). Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT. Leukemia, 34, 87–99. https://doi.org/10.1038/s41375-019-0527-4

Allogeneic haemopoietic cell transplant (allo-HCT) may be curative in acute myeloid leukaemia (AML) in second complete remission (CR2) but the impact of reduced intensity (RIC) versus myeloablative conditioning (MAC) is uncertain. The Acute Leukaemia... Read More about Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT.

Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior (2019)
Journal Article
Vaithilingam, J., Sanjuan‐Alberte, P., Campora, S., Rance, G. A., Jiang, L., Thorpe, J., Burroughs, L., Tuck, C. J., Denning, C., Wildman, R. D., Hague, R. J. M., Alexander, M. R., & Rawson, F. J. (2019). Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior. Advanced Functional Materials, 29(38), Article 1902016. https://doi.org/10.1002/adfm.201902016

Biological structures control cell behavior via physical, chemical, electrical, and mechanical cues. Approaches that allow us to build devices that mimic these cues in a combinatorial way are lacking due to there being no suitable instructive materia... Read More about Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior.

The effect of oral essential amino acids on incretin hormone production in youth and ageing (2019)
Journal Article
Abdulla, H., Bass, J., Stokes, T., Gorissen, S., McGlory, C., Phillips, B., Phillips, S., Smith, K., Idris, I., & Atherton, P. (2019). The effect of oral essential amino acids on incretin hormone production in youth and ageing. Endocrinology, Diabetes and Metabolism, 2(4), Article e00085. https://doi.org/10.1002/edm2.85

Background
The effect of substantive doses of essential amino acids (EAA) on incretin and insulin production, and the impact of age upon this effect, is ill‐defined.

Methods
A 15‐g oral EAA drink was administered to young (N = 8; 26 ± 4.4 years)... Read More about The effect of oral essential amino acids on incretin hormone production in youth and ageing.

Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron (2019)
Journal Article
Gunn, D., Garsed, K., Lam, C., Singh, G., Lingaya, M., Wahl, V., Niesler, B., Henry, A., Hall, I. P., Whorwell, P., & Spiller, R. (2019). Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron. Alimentary Pharmacology and Therapeutics, 50(5), 538-546. https://doi.org/10.1111/apt.15420

Background
Irritable bowel syndrome with diarrhoea (IBS‐D) is a common condition, greatly reducing the quality of life with few effective treatment options available.

Aims
To report the beneficial response shown in our trial with the 5‐hydroyxtr... Read More about Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron.

Speech, movement and gaze behaviours during dyadic conversation in noise (2019)
Journal Article
Hadley, L. V., Owen Brimijoin, W., & Whitmer, W. M. (2019). Speech, movement and gaze behaviours during dyadic conversation in noise. Scientific Reports, 9, Article 10451. https://doi.org/10.1038/s41598-019-46416-0

How do people have conversations in noise and make themselves understood? While many previous studies have investigated speaking and listening in isolation, this study focuses on the behaviour of pairs of individuals in an ecologically valid context.... Read More about Speech, movement and gaze behaviours during dyadic conversation in noise.

Age-related differentiation in verbal and visuo-spatial working memory processing in childhood (2019)
Journal Article
Buttelmann, F., Könen, T., Hadley, L. V., Meaney, J.-A., Auyeung, B., Morey, C. C., Chevalier, N., & Karbach, J. (2020). Age-related differentiation in verbal and visuo-spatial working memory processing in childhood. Psychological Research, 84, 2354–2360. https://doi.org/10.1007/s00426-019-01219-w

Working memory (WM), a key feature of the cognitive system, allows for maintaining and processing information simultaneously and in a controlled manner. WM processing continuously develops across childhood, with significant increases both in verbal a... Read More about Age-related differentiation in verbal and visuo-spatial working memory processing in childhood.

Evaluating a process of academic detailing in primary care: an educational programme for acute kidney injury (2019)
Journal Article
Noble, R. A., McKinnell, J. C., Shaw, S., Bassett, S., Woods, L., Asrar, M., Kolhe, N. V., & Selby, N. M. (2019). Evaluating a process of academic detailing in primary care: an educational programme for acute kidney injury. BMC Medical Education, 19, Article 253. https://doi.org/10.1186/s12909-019-1659-y

Background
Primary care has a significant role in AKI management: two-thirds of AKI originates in the community. Through academic detailing (an evidence-based educational approach) we aimed to implement and measure the effect of a primary care-based... Read More about Evaluating a process of academic detailing in primary care: an educational programme for acute kidney injury.

Donor outcomes in anonymous live liver donation (2019)
Journal Article
Goldaracena, N., Jung, J., Aravinthan, A. D., Abbey, S. E., Krause, S., Pritlove, C., Lynch, J., Wright, L., Selzner, N., Stunguris, J., Grieg, P., Ghanekar, A., McGilvray, I., Sapisochin, G., Lee, V., Levy, G., Cattral, M., & Grant, D. (2019). Donor outcomes in anonymous live liver donation. Journal of Hepatology, 71(5), 951-959. https://doi.org/10.1016/j.jhep.2019.06.027

Background
Death rates on liver transplant waiting lists range from 5%-25%. Herein, we report a unique experience with 50 anonymous persons who volunteered to address this gap by offering to donate part of their liver to a recipient with whom they h... Read More about Donor outcomes in anonymous live liver donation.