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Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT

Gilleece, Maria H.; Labopin, Myriam; Savani, Bipin N.; Yakoub-Agha, Ibrahim; Soci�, Gerard; Gedde-Dahl, Tobias; Blaise, Didier; Byrne, Jennifer L.; Craddock, Charles; Cornelissen, Jan L.; Arcese, William; Forcade, Edouard; Crawley, Charles; Polge, Emmanuelle; Mohty, Mohamad; Nagler, Arnon

Authors

Maria H. Gilleece

Myriam Labopin

Bipin N. Savani

Ibrahim Yakoub-Agha

Gerard Soci�

Tobias Gedde-Dahl

Didier Blaise

Jennifer L. Byrne

Charles Craddock

Jan L. Cornelissen

William Arcese

Edouard Forcade

Charles Crawley

Emmanuelle Polge

Mohamad Mohty

Arnon Nagler



Abstract

Allogeneic haemopoietic cell transplant (allo-HCT) may be curative in acute myeloid leukaemia (AML) in second complete remission (CR2) but the impact of reduced intensity (RIC) versus myeloablative conditioning (MAC) is uncertain. The Acute Leukaemia Working Party of the European Society for Blood and Bone Marrow Transplantation Registry studied an AML CR2 cohort characterised by age ≥ 18 years, first allo-HCT 2007–2016, available cytogenetic profile at diagnosis, donors who were matched family, volunteer unrelated with HLA antigen match 10/10 or 9/10 or haplo-identical. The 1879 eligible patients included 1010 (54%) MAC allo-HCT recipients. In patients

Citation

Gilleece, M. H., Labopin, M., Savani, B. N., Yakoub-Agha, I., Socié, G., Gedde-Dahl, T., …Nagler, A. (2019). Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT. Leukemia, 34, 87–99. https://doi.org/10.1038/s41375-019-0527-4

Journal Article Type Article
Acceptance Date Jun 6, 2019
Online Publication Date Jul 30, 2019
Publication Date Jul 30, 2019
Deposit Date Jun 13, 2019
Publicly Available Date Mar 28, 2024
Journal Leukemia
Print ISSN 0887-6924
Electronic ISSN 1476-5551
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 34
Pages 87–99
DOI https://doi.org/10.1038/s41375-019-0527-4
Keywords Anesthesiology and Pain Medicine; Cancer Research; Hematology
Public URL https://nottingham-repository.worktribe.com/output/2183127
Publisher URL https://www.nature.com/articles/s41375-019-0527-4

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