Outputs (144)

Comprehensive analysis of differentially expressed mRNA profiles in chicken jejunum and cecum following Eimeria maxima infection (2024)
Journal Article
Jebessa, E., Bello, S. F., Xu, Y., Cai, B., Tuli, M. D., Girma, M., Bordbar, F., Hanotte, O., & Nie, Q. (2024). Comprehensive analysis of differentially expressed mRNA profiles in chicken jejunum and cecum following Eimeria maxima infection. Poultry Science, 103(6), Article 103716. https://doi.org/10.1016/j.psj.2024.103716

Coccidiosis, a protozoan disease that substantially impacts poultry production, is characterized by an intracellular parasite. The study utilized 48 one-day-old Horro chickens, randomly divided into the infected (I) and control (C) groups. The challe... Read More about Comprehensive analysis of differentially expressed mRNA profiles in chicken jejunum and cecum following Eimeria maxima infection.

Scalable bioreactor production of an O2‐protected [FeFe]‐hydrogenase enables simple aerobic handling for clean chemical synthesis (2024)
Journal Article
Cleary, S. E., Hall, S. J., Galan-Bataller, R., Lurshay, T. C., Hancox, C., Williamson, J. J., Heap, J. T., Reeve, H. A., & Morra, S. (2024). Scalable bioreactor production of an O2‐protected [FeFe]‐hydrogenase enables simple aerobic handling for clean chemical synthesis. ChemCatChem, 16(16), Article e202400193. https://doi.org/10.1002/cctc.202400193

The enzyme CbA5H, a [FeFe]-hydrogenase from Clostridium beijerinckii, has previously been shown to survive exposure to oxygen, making it a promising candidate for biotechnological applications. Thus far [NiFe]-hydrogenases are typically considered fo... Read More about Scalable bioreactor production of an O2‐protected [FeFe]‐hydrogenase enables simple aerobic handling for clean chemical synthesis.

Phylogenetic insights into the terrestrial snails Helicoidei (Gastropoda: Stylommatophora) with special emphasis on the Camaenidae (2024)
Journal Article
Zhang, G., Naggs, F., Andrus, P. S., & Wade, C. M. (2025). Phylogenetic insights into the terrestrial snails Helicoidei (Gastropoda: Stylommatophora) with special emphasis on the Camaenidae. Zoological Journal of the Linnean Society, 203(1), Article zlae027. https://doi.org/10.1093/zoolinnean/zlae027

The superfamily Helicoidei are a widely distributed and diverse infraorder of land snails and slugs. Here, we constructed a phylogenetic tree based on sequences of the large subunit ribosomal RNA gene to investigate the relationships within the Helic... Read More about Phylogenetic insights into the terrestrial snails Helicoidei (Gastropoda: Stylommatophora) with special emphasis on the Camaenidae.

Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review (2024)
Journal Article
Papapetropoulos, A., Topouzis, S., Alexander, S. P. H., Cortese‐Krott, M., Kendall, D. A., Martemyanov, K. A., Mauro, C., Nagercoil, N., Panettieri, R. A., Patel, H. H., Schulz, R., Stefanska, B., Stephens, G. J., Teixeira, M. M., Vergnolle, N., Wang, X., & Ferdinandy, P. (2024). Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review. British Journal of Pharmacology, 181(11), 1553-1575. https://doi.org/10.1111/bph.16337

In 2023, seventy novel drugs received market authorization for the first time in either Europe (by the EMA and the MHRA) or in the United States (by the FDA). Confirming a steady recent trend, more than half of these drugs target rare diseases or int... Read More about Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review.

CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans (2024)
Journal Article
White, C. W., Platt, S., Kilpatrick, L. E., Dale, N., Abhayawardana, R. S., Dekkers, S., Kindon, N. D., Kellam, B., Stocks, M. J., Pfleger, K. D. G., & Hill, S. J. (2024). CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans. Science Signaling, 17(828), Article abl3758. https://doi.org/10.1126/scisignal.abl3758

CXCL17 is a chemokine principally expressed by mucosal tissues, where it facilitates chemotaxis of monocytes, dendritic cells, and macrophages and has antimicrobial properties. CXCL17 is also implicated in the pathology of inflammatory disorders and... Read More about CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans.

Differentiation of Bulinus senegalensis and Bulinus forskalii Snails in West Africa Using Morphometric Analysis (2024)
Journal Article
Andrus, P. S., Joof, E., & Wade, C. M. (2024). Differentiation of Bulinus senegalensis and Bulinus forskalii Snails in West Africa Using Morphometric Analysis. Acta Parasitologica, 69, 1016-1026. https://doi.org/10.1007/s11686-024-00830-1

Purpose: Accurate identification of medically important intermediate host and vector species is crucial for understanding disease transmission and control. Identifying Bulinus snails which act as intermediate host species for the transmission of schi... Read More about Differentiation of Bulinus senegalensis and Bulinus forskalii Snails in West Africa Using Morphometric Analysis.

Landscape genomics reveals regions associated with adaptive phenotypic and genetic variation in Ethiopian indigenous chickens (2024)
Journal Article
Kebede, F. G., Derks, M. F., Dessie, T., Hanotte, O., Barros, C. P., Crooijmans, R. P., Komen, H., & Bastiaansen, J. W. (2024). Landscape genomics reveals regions associated with adaptive phenotypic and genetic variation in Ethiopian indigenous chickens. BMC Genomics, 25(1), Article 284. https://doi.org/10.1186/s12864-024-10193-6

Climate change is a threat to sustainable livestock production and livelihoods in the tropics. It has adverse impacts on feed and water availability, disease prevalence, production, environmental temperature, and biodiversity. Unravelling the drivers... Read More about Landscape genomics reveals regions associated with adaptive phenotypic and genetic variation in Ethiopian indigenous chickens.

The Role of Extracellular Vesicles in Atopic Dermatitis (2024)
Journal Article
Harvey-Seutcheu, C., Hopkins, G., & Fairclough, L. C. (2024). The Role of Extracellular Vesicles in Atopic Dermatitis. International Journal of Molecular Sciences, 25(6), Article 3255. https://doi.org/10.3390/ijms25063255

Atopic dermatitis, or eczema, is the most common chronic skin disorder, characterized by red and pruritic lesions. Its etiology is multifaceted, involving an interplay of factors, such as the allergic immune response, skin barrier dysfunction, and dy... Read More about The Role of Extracellular Vesicles in Atopic Dermatitis.

Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats (2024)
Journal Article
Gonçalves, S. V., Woodhams, S. G., Li, L., Hathway, G. J., & Chapman, V. (2024). Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats. PAIN Reports, 9(2), Article e1145. https://doi.org/10.1097/pr9.0000000000001145

IntroductionSustained opioid use has long-term negative impacts on future pain experience, particularly in women. This study aimed to investigate the underlying spinal neurobiology of this clinical observation in an experimental model of joint pain.O... Read More about Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats.

Rising water temperature in rivers: Ecological impacts and future resilience (2024)
Journal Article
Johnson, M. F., Albertson, L. K., Algar, A. C., Dugdale, S. J., Edwards, P., England, J., Gibbins, C., Kazama, S., Komori, D., MacColl, A. D., Scholl, E. A., Wilby, R. L., Roque, F. O., & Wood, P. J. (2024). Rising water temperature in rivers: Ecological impacts and future resilience. Wiley Interdisciplinary Reviews: Water, 11(4), Article e1724. https://doi.org/10.1002/wat2.1724

Rising water temperatures in rivers due to climate change are already having observable impacts on river ecosystems. Warming water has both direct and indirect impacts on aquatic life, and further aggravates pervasive issues such as eutrophication, p... Read More about Rising water temperature in rivers: Ecological impacts and future resilience.