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Outputs (18)

Physiological roles of macrophages (2017)
Journal Article
Gordon, S., & Martinez-Pomares, L. (in press). Physiological roles of macrophages. Pflügers Archiv European Journal of Physiology, https://doi.org/10.1007/s00424-017-1945-7

Macrophages are present in mammals from midgestation, contributing to physiologic homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors during embryonic development in the mouse and persist in different organs as h... Read More about Physiological roles of macrophages.

Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection (2016)
Journal Article
Chukwuanukwu, R. C., Onyenekwe, C. C., Martinez-Pomares, L., Flynn, R. J., Singh, S., Amilo, G. I., Agbakoba, N. R., & Okoye, J. O. (in press). Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection. Clinical and Experimental Immunology, 187(2), https://doi.org/10.1111/cei.12861

Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African reg... Read More about Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection.

Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography (2016)
Journal Article
Chowdhury, A. H., Camara, M., Martinez-Pomares, L., Zaitoun, A. M., Eremin, O., Aithal, G. P., & Lobo, D. (2016). Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography. Clinical Science, 130(17), 1535-1544. https://doi.org/10.1042/CS20160326

© 2016 The Author(s). This prospective observational study investigated monocyte cytokine responses to lipopolysaccharide (LPS) in patients with obstructive jaundice (OJ) before and after endoscopic biliary drainage. Dendritic cell (DC) subsets and t... Read More about Immune dysfunction in patients with obstructive jaundice before and after endoscopic retrograde cholangiopancreatography.

Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-γ-treated macrophages to pseudomonas aeruginosa infection (2015)
Journal Article
Singh, S., Barr, H. L., Liu, Y.-C., Robins, A., Heeb, S., Williams, P., Fogarty, A. W., Cámara, M., & Martinez-Pomares, L. (2015). Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-γ-treated macrophages to pseudomonas aeruginosa infection. PLoS ONE, 10(2), Article e0117447. https://doi.org/10.1371/journal.pone.0117447

Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe infections at compromised epithelial surfaces, such those found in burns, wounds, and in lungs damaged by mechanical ventilation or recurrent infections, particularly in cystic... Read More about Granulocyte-macrophage colony stimulatory factor enhances the pro-inflammatory response of interferon-γ-treated macrophages to pseudomonas aeruginosa infection.

Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters (2015)
Journal Article
Khairalla, A. S., Omer, S. A., Mahdavi, J., Aslam, A., Dufailu, O. A., Self, T., Jonsson, A.-B., Geörg, M., Sjölinder, H., Royer, P.-J., Martinez-Pomares, L., Ghaemmaghami, A. M., Wooldridge, K. G., Oldfield, N. J., & Ala'Aldeen, D. A. (2015). Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters. Cellular Microbiology, 17(7), 1008-1020. https://doi.org/10.1111/cmi.12417

Neisseria meningitidis, a major cause of bacterial meningitis and septicaemia, secretes multiple virulence factors, including the adhesion and penetration protein (App) and meningococcal serine protease A (MspA). Both are conserved, immunogenic, type... Read More about Nuclear trafficking, histone cleavage and induction of apoptosis by the meningococcal App and MspA autotransporters.

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins (2010)
Journal Article
Coelho, V., Krysov, S., Ghaemmaghami, A. M., Emara, M., Potter, K. N., Johnson, P., Packham, G., Martinez-Pomares, L., & Stevenson, F. K. (2010). Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins. Proceedings of the National Academy of Sciences, 107(43), 18587-18592. https://doi.org/10.1073/pnas.1009388107

Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation a... Read More about Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins.

The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity (2010)
Journal Article
Royer, P. J., Emara, M., Yang, C., Al-Ghouleh, A., Tighe, P., Jones, N., Sewell, H. F., Shakib, F., Martinez-Pomares, L., & Ghaemmaghami, A. M. (2010). The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity. Journal of Immunology, 185(3), 1522-1531. https://doi.org/10.4049/jimmunol.1000774

The mannose receptor (MR) is a C-type lectin expressed by dendritic cells (DCs). We have investigated the ability of MR to recognize glycosylated allergens. Using a gene silencing strategy, we have specifically inhibited the expression of MR on human... Read More about The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO Activity.