Outputs (12)

Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception (2025)
Journal Article
McGing, J. J., Serres, S., Nicholas, R., Gupta, A., Radford, S. J., Nixon, A. V., Mallinson, J., Bradley, C., Bawden, S., Francis, S. T., Greenhaff, P. L., & Moran, G. W. (in press). Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception. Journal of Crohn's and Colitis, Article jjae194. https://doi.org/10.1093/ecco-jcc/

Background & Objective

IBD fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and functio... Read More about Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perception.

DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 (2024)
Journal Article
Gupta, A., Nicholas, R., McGing, J. J., Nixon, A. V., Mallinson, J. E., McKeever, T. M., Bradley, C. R., Piasecki, M., Cox, E. F., Bonnington, J., Lord, J. M., Brightling, C. E., Evans, R. A., Hall, I. P., Francis, S. T., Greenhaff, P. L., & Bolton, C. E. (2024). DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19. Experimental Physiology, 109(8), 1274-1291. https://doi.org/10.1113/ep091590

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited... Read More about DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19.

Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women (2023)
Journal Article
Mallinson, J. E., Wardle, S. L., O'Leary, T. J., Greeves, J. P., Cegielski, J., Bass, J., Brook, M. S., Wilkinson, D. J., Smith, K., Atherton, P. J., & Greenhaff, P. L. (2023). Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women. Scandinavian Journal of Medicine and Science in Sports, 33(12), 2470-2481. https://doi.org/10.1111/sms.14506

Studies examining the effect of protein (PRO) feeding on post resistance exercise (RE) muscle protein synthesis (MPS) have primarily been performed in men, and little evidence is available regarding the quantity of PRO required to maximally stimulate... Read More about Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women.

Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestion in overweight and obese men: A randomised crossover trial (2022)
Journal Article
Wilhelmsen, A., Davies, A., Mallinson, J., Pabla, P., Jones, R., Palmer, E. A., Dunn, W. B., Moran, G. W., Stephens, F. B., & Tsintzas, K. (2022). Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestion in overweight and obese men: A randomised crossover trial. Clinical Nutrition, 41(8), 1623-1635. https://doi.org/10.1016/j.clnu.2022.06.022

Background: Obesity and insulin resistance are associated with an impaired sensitivity to anabolic stimuli such as dietary protein (anabolic resistance). Omega-3 polyunsaturated fatty acids (n-3 PUFA) may be protective against the deleterious effects... Read More about Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestion in overweight and obese men: A randomised crossover trial.

Immobilisation induces sizeable and sustained reductions in forearm glucose uptake in just 24h but does not change lipid uptake in healthy men (2021)
Journal Article
Burns, A. M., Nixon, A., Mallinson, J., Cordon, S. M., Stephens, F. B., & Greenhaff, P. L. (2021). Immobilisation induces sizeable and sustained reductions in forearm glucose uptake in just 24h but does not change lipid uptake in healthy men. Journal of Physiology, 599(8), 2197-2210. https://doi.org/10.1113/JP281021

© 2021 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society Key points: The trajectory, magnitude and localisation of metabolic perturbations caused by immobilisation (IMM) are unresolved.... Read More about Immobilisation induces sizeable and sustained reductions in forearm glucose uptake in just 24h but does not change lipid uptake in healthy men.

Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men (2020)
Journal Article
Tsintzas, K., Jones, R., Pabla, P., Mallinson, J., Barrett, D. A., Kim, D. H., Cooper, S., Davies, A., Taylor, T., Chee, C., Gaffney, C., van Loon, L. J. C., & Stephens, F. B. (2020). Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men. AJP - Endocrinology and Metabolism, 318(3), E417-E429. https://doi.org/10.1152/ajpendo.00344.2019

Muscle anabolic resistance to dietary protein is associated with obesity and insulin resistance. However, the contribution of excess consumption of fat to anabolic resistance is not well studied. The aim of these studies was to test the hypothesis th... Read More about Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight, and obese men.

Chronic effects of high-intensity interval training on postprandial lipemia in healthy men (2019)
Journal Article
Wilhelmsen, A. J., Tsintzas, K., Mallinson, J., Jones, R., Cooper, S., & Taylor, T. (2019). Chronic effects of high-intensity interval training on postprandial lipemia in healthy men. Journal of Applied Physiology, 127(6), 1763-1771. https://doi.org/10.1152/japplphysiol.00131.2019

The aim of this study was to determine thechronic (≥72h post-exercise) effects of high intensity interval training (HIIT) on postprandial lipaemia and metabolic markers in healthy volunteers. Eight physically active young males (Mean ± SD: age 22 ± 3... Read More about Chronic effects of high-intensity interval training on postprandial lipemia in healthy men.

Muscle thickness correlates to muscle cross sectional area in the assessment of strength training induced hypertrophy (2017)
Journal Article
Franchi, M. V., Longo, S., Mallinson, J. E., Quinlan, J. I., Taylor, T., Greenhaff, P. L., & Narici, M. V. (in press). Muscle thickness correlates to muscle cross sectional area in the assessment of strength training induced hypertrophy. Scandinavian Journal of Medicine and Science in Sports, 28(3), https://doi.org/10.1111/sms.12961

Aim: Muscle thickness (MT) measured by ultrasound has been used to estimate cross-sectional area (measured by CT and MRI) at a single time-point. We tested whether MT could be used as a valid marker of MRI determined muscle anatomical cross-sectional... Read More about Muscle thickness correlates to muscle cross sectional area in the assessment of strength training induced hypertrophy.

Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men (2017)
Journal Article
Tsintzas, K., Stephens, F. B., Snijders, T., Wall, B. T., Cooper, S., Mallinson, J., Verdijk, L. B., & van Loon, L. J. (2017). Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men. Experimental Gerontology, 93, https://doi.org/10.1016/j.exger.2017.03.018

The aim of this study was to examine the temporal relationship between intramyocellular lipid (IMCL) content and the expression of genes associated with IMCL turnover, fat metabolism, and inflammation during recovery from an acute bout of resistance... Read More about Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men.

Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function. (2015)
Journal Article
Murton, A. J., Marimuthu, K., Mallinson, J. E., Selby, A. L., Smith, K., Rennie, M. J., & Greenhaff, P. L. (2015). Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function. Diabetes, 64(9), https://doi.org/10.2337/db15-0021

Obesity is increasing, yet despite the necessity to maintain muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown. Eleven obese (BMI 31.9 ±1.1) and 15 healthy weight (HW; BMI 23.4 ±0.3) o... Read More about Obesity appears to be associated with altered muscle protein synthetic and breakdown responses to increased nutrient delivery in older men, but not reduced muscle mass or contractile function..