Outputs (167)

Recombinase-independent chromosomal rearrangements between dispersed inverted repeats in Saccharomyces cerevisiae meiosis (2023)
Journal Article
Allison, R. M., Johnson, D. J., Neale, M. J., & Gray, S. (2023). Recombinase-independent chromosomal rearrangements between dispersed inverted repeats in Saccharomyces cerevisiae meiosis. Nucleic Acids Research, 51(18), 9703-9715. https://doi.org/10.1093/nar/gkad650

DNA double-strand break (DSB) repair by homologous recombination (HR) uses a DNA template with similar sequence to restore genetic identity. Allelic DNA repair templates can be found on the sister chromatid or homologous chromosome. During meiotic re... Read More about Recombinase-independent chromosomal rearrangements between dispersed inverted repeats in Saccharomyces cerevisiae meiosis.

Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study (2023)
Journal Article
Hamill, V., Wong, S., Benselin, J., Krajden, M., Hayes, P. C., Mutimer, D., …Innes, H. (2023). Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study. BMJ, 382, Article e074001. https://doi.org/10.1136/bmj-2022-074001

Objectives To quantify mortality rates for patients successfully treated for hepatitis C in the era of interferon-free, direct acting antivirals and compare these rates with those of the general population. Design Population based cohort study.... Read More about Mortality rates among patients successfully treated for hepatitis C in the era of interferon-free antivirals: population based cohort study.

Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2 (2023)
Journal Article
Casella, B. M., Farmer, J. P., Nesheva, D. N., Williams, H. E., Charlton, S. J., Holliday, N. D., …Mistry, S. N. (2023). Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.3c00849

The inhibition of CXC chemokine receptor 2 (CXCR2), a key inflammatory mediator, is a potential strategy in the treatment of several pulmonary diseases and cancers. The complexity of endogenous chemokine interaction with the orthosteric binding site... Read More about Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2.

Genome-wide diversity and admixture of five indigenous cattle populations from the Tigray region of northern Ethiopia (2023)
Journal Article
Zegeye, T., Belay, G., Vallejo-Trujillo, A., Han, J., & Hanotte, O. (2023). Genome-wide diversity and admixture of five indigenous cattle populations from the Tigray region of northern Ethiopia. Frontiers in Genetics, 14, Article 1050365. https://doi.org/10.3389/fgene.2023.1050365

The Tigray region, where we found around eight per cent of the indigenous cattle population of Ethiopia, is considered as the historic centre of the country, with the ancient pre-Aksumite and Aksumite civilisations in contact with the civilisations o... Read More about Genome-wide diversity and admixture of five indigenous cattle populations from the Tigray region of northern Ethiopia.

The impact of respiratory infections and probiotic use on the nasal microbiota of frail residents in long-term care homes (2023)
Journal Article
Bowdish, D. M. E., Rossi, L., Loeb, M., Johnstone, J., Schenck, L. P., Fontes, M., …Whelan, F. J. (2023). The impact of respiratory infections and probiotic use on the nasal microbiota of frail residents in long-term care homes. ERJ Open Research, 9(5), Article 00212-2023. https://doi.org/10.1183/23120541.00212-2023

Background Residents in long-term care homes, who tend to be of advanced age and frail, are at increased risk of respiratory infections. The respiratory microbiota is known to change with age, but whether these changes contribute to the risk of infec... Read More about The impact of respiratory infections and probiotic use on the nasal microbiota of frail residents in long-term care homes.

Assessment of the potential of novel and classical opioids to induce respiratory depression in mice (2023)
Journal Article
Hill, R., Sanchez, J., Lemel, L., Antonijevic, M., Hosking, Y., Mistry, S. N., …Canals, M. (2023). Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. British Journal of Pharmacology, 180(24), 3160-3174. https://doi.org/10.1111/bph.16199

Background and Purpose Opioid-induced respiratory depression limits the use of μ-opioid receptor agonists in clinical settings and is the main cause of opioid overdose fatalities. The relative potential of different opioid agonists to induce respira... Read More about Assessment of the potential of novel and classical opioids to induce respiratory depression in mice.

Comparing shell size and shape with canonical variate analysis of sympatric Biomphalaria species within Lake Albert and Lake Victoria, Uganda (2023)
Journal Article
Andrus, P. S., Stothard, J. R., Kabatereine, N. B., & Wade, C. M. (2023). Comparing shell size and shape with canonical variate analysis of sympatric Biomphalaria species within Lake Albert and Lake Victoria, Uganda. Zoological Journal of the Linnean Society, 199(3), 713–722. https://doi.org/10.1093/zoolinnean/zlad052

The Great African Lakes in Uganda (Lake Albert and Lake Victoria) are known habitats to several sympatric species of Biomphalaria, intermediate snail hosts of the human parasite Schistosoma mansoni. However, accurate identification of snails by morph... Read More about Comparing shell size and shape with canonical variate analysis of sympatric Biomphalaria species within Lake Albert and Lake Victoria, Uganda.

Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis (2023)
Journal Article
Hall, C. M., Lasli, S., Serwinski, B., Djordjevic, B., Sheridan, G. K., & Moeendarbary, E. (2023). Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis. Frontiers in Aging Neuroscience, 15, Article 1212212. https://doi.org/10.3389/fnagi.2023.1212212

Widespread neurodegeneration, enlargement of cerebral ventricles, and atrophy of cortical and hippocampal brain structures are classic hallmarks of Alzheimer’s disease (AD). Prominent macroscopic disturbances to the cytoarchitecture of the AD brain o... Read More about Hippocampus of the APP NL–G–F mouse model of Alzheimer’s disease exhibits region-specific tissue softening concomitant with elevated astrogliosis.

Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells (2023)
Journal Article
Hill, S. J., & Kilpatrick, L. E. (2023). Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells. British Journal of Pharmacology, https://doi.org/10.1111/bph.16185

Equilibrium binding assays are one of the mainstays of current drug discovery efforts to evaluate the interaction of drugs with receptors in membranes and intact cells. However, in recent years, there has been increased focus on the kinetics of the d... Read More about Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells.

Escherichia coli DNA repair helicase Lhr is also a uracil‐DNA glycosylase (2023)
Journal Article
Buckley, R. J., Lou‐Hing, A., Hanson, K. M., Ahmed, N. R., Cooper, C. D. O., & Bolt, E. L. (2023). Escherichia coli DNA repair helicase Lhr is also a uracil‐DNA glycosylase. Molecular Microbiology, 120(2), 298-306. https://doi.org/10.1111/mmi.15123

DNA glycosylases protect genetic fidelity during DNA replication by removing potentially mutagenic chemically damaged DNA bases. Bacterial Lhr proteins are well‐characterized DNA repair helicases that are fused to additional 600–700 amino acids of un... Read More about Escherichia coli DNA repair helicase Lhr is also a uracil‐DNA glycosylase.