Outputs (2)

Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model (2019)
Journal Article
Costa-Marques, L., Arnold, K., Pardon, M. C., Leovsky, C., Swarbrick, S., Fabian, C., & Stolzing, A. (2019). Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model. Translational Neurodegeneration, 8, Article 33. https://doi.org/10.1186/s40035-019-0173-9

© 2019 The Author(s). Background: We investigated early hallmarks of putative therapeutic effects following systemic transplantation of bone marrow derived macrophages (BM-M) in APP/PS1 transgenic mice. Method: BM-M were transplanted into the tail ve... Read More about Transplantation of bone marrow derived macrophages reduces markers of neuropathology in an APP/PS1 mouse model.

Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease (2019)
Journal Article
Agostini, A., Yuchun, D., Li, B., Kendall, D. A., & Pardon, M. (2020). Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Brain, Behavior, and Immunity, 83, 87-111. https://doi.org/10.1016/j.bbi.2019.09.019

Systemic inflammation enhances the risk and progression of Alzheimer's disease (AD). Lipopolysaccharide (LPS), a potent pro-inflammatory endotoxin produced by the gut, is found in excess levels in AD where it associates with neurological hallmarks of... Read More about Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease.