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Outputs (212)

Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae (2016)
Journal Article
Willis, A. R., Moore, C., Mazon-Moya, M., Krokowski, S., Lambert, C., Till, R., …Sockett, R. E. (2016). Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae. Current Biology, 26(24), 3343-3351. https://doi.org/10.1016/j.cub.2016.09.067

Bdellovibrio bacteriovorus are predatory bacteria that invade and kill a range of Gram-negative bacterial pathogens in natural environments and in vitro [ 1 and 2]. In this study, we investigated Bdellovibrio as an injected, antibacterial treatment i... Read More about Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae.

A review of recent evidence relating to sugars, insulin resistance and diabetes (2016)
Journal Article
MacDonald, I. A. (in press). A review of recent evidence relating to sugars, insulin resistance and diabetes. European Journal of Nutrition, 55(S2), https://doi.org/10.1007/s00394-016-1340-8

The potential impact on health of diets rich in free sugars, and particularly fructose, is of major concern. The focus of this review is the impact of these sugars on insulin resistance and obesity, and the associated risk of developing type 2 diabet... Read More about A review of recent evidence relating to sugars, insulin resistance and diabetes.

Selective sweep on human amylase genes postdates the split with Neanderthals (2016)
Journal Article
Inchley, C. E., Larbey, C. D., Shwan, N. A., Pagani, L., Saag, L., Antão, T., …Kivisild, T. (in press). Selective sweep on human amylase genes postdates the split with Neanderthals. Scientific Reports, 6, https://doi.org/10.1038/srep37198

Humans have more copies of amylase genes than other primates. It is still poorly understood, however, when the copy number expansion occurred and whether its spread was enhanced by selection. Here we assess amylase copy numbers in a global sample of... Read More about Selective sweep on human amylase genes postdates the split with Neanderthals.

Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain (2016)
Journal Article
Huang, J., Burston, J. J., Li, L., Ashraf, S., Mapp, P. I., Bennett, A. J., …Chapman, V. (2017). Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain. Arthritis and Rheumatology, 69(5), 996-1008. https://doi.org/10.1002/art.40001

Objective: Pain is a major symptom of osteoarthritis (OA); current analgesics either do not offer adequate pain relief or are associated with serious side effects. Herein we have investigated the therapeutic potential of targeting the resolvin recept... Read More about Targeting the D-series resolvin receptor system for the treatment of osteoarthritic pain.

Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa (2016)
Journal Article
Rampioni, G., Falcone, M., Heeb, S., Frangipani, E., Fletcher, M. P., Dubern, J., …Williams, P. (2016). Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa. PLoS Pathogens, 12(11), e1006029. https://doi.org/10.1371/journal.ppat.1006029

The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both in vitro and in animal models of infection and is considered an ideal target for the development of anti-virulence agents. However, the precise role played by eac... Read More about Unravelling the Genome-Wide Contributions of Specific 2-Alkyl-4-Quinolones and PqsE to Quorum Sensing in Pseudomonas aeruginosa.

Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions (2016)
Journal Article
Manzi, L., Barrow, A. S., Scott, D., Layfield, R., Wright, T. G., Moses, J. E., & Oldham, N. J. (2016). Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions. Nature Communications, 7, Article 13288. https://doi.org/10.1038/ncomms13288

Specific interactions between proteins and their binding partners are fundamental to life processes. The ability to detect protein complexes, and map their sites of binding, is crucial to understanding basic biology at the molecular level. Methods th... Read More about Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions.

Why many Batesian mimics are inaccurate: evidence from hoverfly colour patterns (2016)
Journal Article
Taylor, C. H., Reader, T., & Gilbert, F. (2016). Why many Batesian mimics are inaccurate: evidence from hoverfly colour patterns. Proceedings of the Royal Society B: Biological Sciences, 283(1842), https://doi.org/10.1098/rspb.2016.1585

Mimicry is considered a classic example of the elaborate adaptations that natural selection can produce, yet often similarity between Batesian (harmless) mimics and their unpalatable models is far from perfect. Variation in mimetic accuracy is a puzz... Read More about Why many Batesian mimics are inaccurate: evidence from hoverfly colour patterns.

27 years of benthic and coral community dynamics on turbid, highly urbanised reefs off Singapore (2016)
Journal Article
Guest, J., Tun, K., Vergés, A., Marzinelli, E., Campbell, A., Bauman, A., …Steinberg, P. (in press). 27 years of benthic and coral community dynamics on turbid, highly urbanised reefs off Singapore. Scientific Reports, 6, Article 36260. https://doi.org/10.1038/srep36260

Coral cover on reefs is declining globally due to coastal development, overfishing and climate change. Reefs isolated from direct human influence can recover from natural acute disturbances, but little is known about long term recovery of reefs exper... Read More about 27 years of benthic and coral community dynamics on turbid, highly urbanised reefs off Singapore.

A multiscale method to calculate filter blockage (2016)
Journal Article
Dalwadi, M. P., Bruna, M., & Griffiths, I. M. (in press). A multiscale method to calculate filter blockage. Journal of Fluid Mechanics, 809, https://doi.org/10.1017/jfm.2016.656

Filters that act by adsorbing contaminant onto their pore walls will experience a decrease in porosity over time, and may eventually block. As adsorption will generally be greater towards the entrance of a filter, where the concentration of contamina... Read More about A multiscale method to calculate filter blockage.