Outputs (2507)

Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells (2024)
Journal Article
Comeo, E., Goulding, J., Lin, C.-Y., Groenen, M., Woolard, J., Kindon, N. D., Harwood, C. R., Platt, S., Briddon, S. J., Kilpatrick, L. E., Scammells, P. J., Hill, S. J., & Kellam, B. (2024). Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells. Journal of Medicinal Chemistry, 67(14), 12099–12117. https://doi.org/10.1021/acs.jmedchem.4c00835

The study of protein function and dynamics in their native cellular environment is essential for progressing fundamental science. To overcome the requirement of genetic modification of the protein or the limitations of dissociable fluorescent ligands... Read More about Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells.

Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R) (2024)
Journal Article
Mach, L., Omran, A., Bouma, J., Radetzki, S., Sykes, D. A., Guba, W., Li, X., Höffelmeyer, C., Hentsch, A., Gazzi, T., Mostinski, Y., Wasinska-Kalwa, M., de Molnier, F., van der Horst, C., von Kries, J. P., Vendrell, M., Hua, T., Veprintsev, D. B., Heitman, L. H., Grether, U., & Nazare, M. (2024). Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R). Journal of Medicinal Chemistry, 67(14), 11841-11867. https://doi.org/10.1021/acs.jmedchem.4c00465

The cannabinoid receptor type 1 (CB1R) is pivotal within the endocannabinoid system regulating various signaling cascades with effects in appetite regulation, pain perception, memory formation, and thermoregulation. Still, understanding of CB1R’s cel... Read More about Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R).

Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance (2024)
Journal Article
Yuan, A., Colonell, J., Lebedeva, A., Okun, M., Charles, A., & Harris, T. D. (2024). Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance. eLife, 12, Article 92495. https://doi.org/10.7554/eLife.92495.3

Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. Advances in high-density extracellular electrophysiology recording probes, such as Neuropixels, provide a... Read More about Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.

Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom (2024)
Journal Article
Hinds, J., Apaa, T., Parry, R. H., Withers, A. J., MacKenzie, L., Staley, C., Morrison, J., Bennett, M., Bremner-Harrison, S., Chadwick, E. A., Hailer, F., Harrison, S. W., Lambin, X., Loose, M., Mathews, F., Tarlinton, R., & Blanchard, A. (2024). Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom. Access Microbiology, 6(7), Article 000813.v4. https://doi.org/10.1099/acmi.0.000813.v4

The Caliciviridae family, comprising positive-sense RNA viruses, is characterised by its non-enveloped, small virions, broad host range, and notable tendency for host switching. These viruses are primarily associated with gastroenteric disease, thoug... Read More about Multiple novel caliciviruses identified from stoats (Mustela erminea) in the United Kingdom.

Effects of interval training in cardiovascular disease populations: a clinical perspective (2024)
Journal Article
Reed, J. L., Way, K. L., O'Neill, C., Marçal, I. R., & Terada, T. (2024). Effects of interval training in cardiovascular disease populations: a clinical perspective. Applied Physiology, Nutrition, and Metabolism, 49(12), 1792-1797. https://doi.org/10.1139/apnm-2024-0022

Nearly 20 years have elapsed since the first clinical trial investigated the impact of interval training on patients with cardiovascular disease (CVD). This clinical corner discusses the health outcomes of systematic reviews and meta-analyses and app... Read More about Effects of interval training in cardiovascular disease populations: a clinical perspective.

Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone (2024)
Journal Article
Kundu, J., Le, H. T., Logan, M., Hockman, D., Landi, A., Crawford, K., Wininger, M., Johnson, J., Kundu, J. K., Tiffney, E. A., Urbanowicz, R. A., Ball, J. K., Bailey, J. R., Bukh, J., Law, M., Foung, S., Tyrrell, D. L., Houghton, M., & Law, J. L. (2024). Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone. Journal of Hepatology, 81(6), 941-948. https://doi.org/10.1016/j.jhep.2024.06.029

Background & Aims: An optimal HCV vaccine requires the induction of antibodies that neutralise the infectivity of many heterogenous viral isolates. In this study, we have focused on determining the optimal recombinant envelope glycoprotein component... Read More about Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone.

Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures (2024)
Journal Article
Schindl, A., Hagen, M. L., Cooley, I., Jäger, C. M., Warden, A. C., Zelzer, M., Allers, T., & Croft, A. K. (2024). Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures. RSC Sustainability, 2(9), 2559-2580. https://doi.org/10.1039/d3su00412k

Biocatalysis in ionic liquids enables novel routes for bioprocessing. Enzymes derived from extremophiles promise greater stability and activity under ionic liquid (IL) influence. Here, we probe the enzyme alcohol dehydrogenase 2 from the halophilic a... Read More about Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures.

Sorting of GPI-anchored proteins at the trypanosome surface is independent of GPI insertion signals (2024)
Journal Article
Miller, T. H., Schiessler, S., Rogerson, E. M., & Gadelha, C. (2024). Sorting of GPI-anchored proteins at the trypanosome surface is independent of GPI insertion signals. The Cell Surface, 12, Article 100131. https://doi.org/10.1016/j.tcsw.2024.100131

The segregation of glycosylphosphatidylinositol-anchored proteins (GPI-APs) to distinct domains on the plasma membrane of eukaryotic cells is important for their correct cellular function, but the mechanisms by which GPI-APs are sorted are yet to be... Read More about Sorting of GPI-anchored proteins at the trypanosome surface is independent of GPI insertion signals.

Thermal tolerance plasticity and dynamics of thermal tolerance in Eublepharis macularius: Implications for future climate-driven heat stress (2024)
Journal Article
White, E., Kim, S., Wegh, G., & Chiari, Y. (2024). Thermal tolerance plasticity and dynamics of thermal tolerance in Eublepharis macularius: Implications for future climate-driven heat stress. Journal of Thermal Biology, 123, Article 103912. https://doi.org/10.1016/j.jtherbio.2024.103912

The intensity and duration of heat waves, as well as average global temperatures, are expected to increase due to climate change. Heat waves can cause physiological stress and reduce fitness in animals. Species can reduce overheating risk through phe... Read More about Thermal tolerance plasticity and dynamics of thermal tolerance in Eublepharis macularius: Implications for future climate-driven heat stress.

How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies? (2024)
Journal Article
Baker, L., Taylor, C., Gilbert, F., & Reader, T. (2024). How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies?. Behavioral Ecology, 35(5), Article arae054. https://doi.org/10.1093/beheco/arae054

Despite Batesian mimicry often eliciting predator avoidance, many Batesian mimics, such as some species of hoverfly (Syrphidae), are considered to have an “imperfect” resemblance to their model. One possible explanation for the persistence of apparen... Read More about How does viewing angle affect the perceived accuracy of Batesian mimicry in hoverflies?.