Skip to main content

Research Repository

Advanced Search

Outputs (20)

The Role of Epithelial-Derived Extracellular Vesicles in Allergic Sensitisation: A Systematic Review (2025)
Journal Article
Browne, W., Hopkins, G., Cochrane, S., James, V., Onion, D., & C. Fairclough, L. (2025). The Role of Epithelial-Derived Extracellular Vesicles in Allergic Sensitisation: A Systematic Review. International Journal of Molecular Sciences, 26(12), Article 5791. https://doi.org/10.3390/ijms26125791

The aim of this systematic review was to evaluate the current evidence for the involvement of epithelial-derived extracellular vesicles (EVs) in Immunoglobulin E (IgE)-mediated allergic sensitisation. Original clinical and research studies specifical... Read More about The Role of Epithelial-Derived Extracellular Vesicles in Allergic Sensitisation: A Systematic Review.

Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain (2025)
Journal Article
Gowler, P. R., Arendt-Tranholm, A., Turnbull, J., Jha, R. R., Onion, D., Kelly, T., Kouraki, A., Millns, P., Gohir, S., Franks, S., Barrett, D. A., Valdes, A. M., & Chapman, V. (2025). Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain. iScience, 28(2), Article 111862. https://doi.org/10.1016/j.isci.2025.111862

Our goal was to probe the potential transcriptomic basis for the relationship between plasma levels of the specialized pro-resolving precursor, 17-hydroxy-docosahexaenoic acid (17-HDHA) and chronic pain. Participants with osteoarthritis (average age... Read More about Monocyte eukaryotic initiation factor 2 (EIF2) signalling differentiates 17-hydroxy-docosahexaenoic acid levels and pain.

Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort) (2024)
Journal Article
Hopkins, G., Gomez, N., Tucis, D., Bartlett, L., Steers, G., Burns, E., Brown, M., Harvey-Cowlishaw, T., Santos, R., Lauder, S. N., Scurr, M., Capitani, L., Burnell, S., Rees, T., Smart, K., Somerville, M., Gallimore, A., Perera, M., Potts, M., Metaxaki, M., …Fairclough, L. (2024). Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort). Journal of Clinical Immunology, 44(6), Article 147. https://doi.org/10.1007/s10875-024-01739-0

Purpose
Asymptomatic SARS-CoV-2 infections were widely reported during the COVID-19 pandemic, acting as a hidden source of infection. Many existing studies investigating asymptomatic immunity failed to recruit true asymptomatic individuals. Thus, we... Read More about Lower Humoral and Cellular Immunity Following Asymptomatic SARS-CoV-2 Infection Compared to Symptomatic Infection in Education (The ACE Cohort).

The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review (2024)
Journal Article
Tucis, D., Hopkins, G., Browne, W., James, V., Onion, D., & Fairclough, L. C. (2024). The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review. International Journal of Molecular Sciences, 25(8), Article 4492. https://doi.org/10.3390/ijms25084492

Allergies affect approximately 10–30% of people worldwide, with an increasing number of cases each year; however, the underlying mechanisms are still poorly understood. In recent years, extracellular vesicles (EVs) have been suggested to play a role... Read More about The Role of Extracellular Vesicles in Allergic Sensitization: A Systematic Review.

The Role of Lipids in Allergic Sensitization: A Systematic Review (2024)
Preprint / Working Paper
Fairclough, L., Hopkins V, G., Cochrane, S., & Onion, D. (2024). The Role of Lipids in Allergic Sensitization: A Systematic Review

Background
Immunoglobulin E (IgE)-mediated allergies are increasing in prevalence, with IgE-mediated food allergies currently affecting up to 10% of children and 6% of adults worldwide. The mechanisms underpinning the first phase of IgE-mediated all... Read More about The Role of Lipids in Allergic Sensitization: A Systematic Review.

Invariant NKT cells are more abundant in peanut-allergic adults and a subset of CD8 + iNKT cells are depleted after peanut oil exposure (2023)
Journal Article
Hopkins, G. V., Cochrane, S., Onion, D., & Fairclough, L. C. (2023). Invariant NKT cells are more abundant in peanut-allergic adults and a subset of CD8 + iNKT cells are depleted after peanut oil exposure. Frontiers in Immunology, 14, Article 1293158. https://doi.org/10.3389/fimmu.2023.1293158

Introduction:

Peanut allergy is one of the most prevalent food allergies globally. Currently, most research into the mechanisms involved in protein allergy focuses on the protein allergens under investigation, and information on the function of a... Read More about Invariant NKT cells are more abundant in peanut-allergic adults and a subset of CD8 + iNKT cells are depleted after peanut oil exposure.

Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells (2023)
Journal Article
Kosar, M., Sykes, D. A., Viray, A. E. G., Vitale, R. M., Sarott, R. C., Ganzoni, R. L., Onion, D., Tobias, J. M., Leippe, P., Ullmer, C., Zirwes, E. A., Guba, W., Grether, U., Frank, J. A., Veprintsev, D. B., & Carreira, E. M. (2023). Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells. Journal of the American Chemical Society, 145(28), 15094–15108. https://doi.org/10.1021/jacs.2c13629

Pharmacological modulation of cannabinoid receptor type 2 (CB2R) holds promise for the treatment of neuroinflammatory disorders, such as Alzheimer’s disease. Despite the importance of CB2R, its expression and downstream signaling are insufficiently u... Read More about Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article
Gomez, N. E., James, V., Arkill, K. P., Nizamudeen, Z. A., Onion, D., & Fairclough, L. C. (2023). PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. European Journal of Immunology, 53(6), Article 2250143. https://doi.org/10.1002/eji.202250143

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination (2022)
Journal Article
Gumber, L., Gomez, N., Hopkins, G., Tucis, D., Bartlett, L., Ayling, K., Vedhara, K., Steers, G., Chakravorty, M., Rutter, M., Jackson, H., Tighe, P., Ferraro, A., Power, S., Pradère, M.-J., Onion, D., Lanyon, P. C., Pearce, F. A., & Fairclough, L. (2023). Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination. Rheumatology, 62(6), 2294-2303. https://doi.org/10.1093/rheumatology/keac574

Objectives: COVID-19 vaccine responses in rare autoimmune rheumatic diseases (RAIRD) remain poorly understood, in particular there is little known about whether people develop effective T-cell responses. We conducted a prospective cohort study to eva... Read More about Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.