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A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., …Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), Article e0201410. https://doi.org/10.1371/journal.pone.0201410

Background & aims

Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

A comprehensive assessment of benign genetic variability for neurodegenerative disorders (2018)
Journal Article
Guerreiro, R., Sassi, C., Gibbs, J., Edsall, C., Hernandez, D., Brown, K., …Bras, J. (2018). A comprehensive assessment of benign genetic variability for neurodegenerative disorders. https://doi.org/10.1101/270686

Over the last few years, as more and more sequencing studies have been performed, it has become apparent that the identification of pathogenic mutations is, more often than not, a complex issue. Here, with a focus on neurodegenerative diseases, we ha... Read More about A comprehensive assessment of benign genetic variability for neurodegenerative disorders.

High mobility group protein B1 is a predictor of poor survival in ovarian cancer (2017)
Journal Article
Machado, L. R., Moseley, P. M., Moss, R., Deen, S., Nolan, C. C., Spendlove, I., …Durrant, L. (2017). High mobility group protein B1 is a predictor of poor survival in ovarian cancer. Oncotarget, https://doi.org/10.18632/oncotarget.20538

High-mobility group protein B1 (HMGB1) has been implicated in numerous tumour types where expression regulates tumour cell growth and survival. We hypothesised that high HMGB1 expression in ovarian tumours would predict poor patient survival.
Using... Read More about High mobility group protein B1 is a predictor of poor survival in ovarian cancer.

MMP-1 activation contributes to airway smooth muscle growth and asthma severity (2016)
Journal Article
Naveed, S.-U.-N., Clements, D., Jackson, D. J., Philp, C., Billington, C. K., Soomro, I. N., Reynolds, C., Harrison, T. W., Johnston, S. L., Shaw, D. E., & Johnson, S. R. (2017). MMP-1 activation contributes to airway smooth muscle growth and asthma severity. American Journal of Respiratory and Critical Care Medicine, 195(8), 1000-1009. https://doi.org/10.1164/rccm.201604-0822OC

Introduction: Matrix metalloproteinase-1 and mast cells are present in the airways of people with asthma. We hypothesised that matrix metalloproteinase-1 could be activated by mast cells and increase asthma severity. Methods: Patients with stable ast... Read More about MMP-1 activation contributes to airway smooth muscle growth and asthma severity.

Cystic Fibrosis isolates of Pseudomonas aeruginosa retain iron-regulated antimicrobial activity against Staphylococcus aureus through the action of multiple alkylquinolones (2016)
Journal Article
Nguyen, A. T., Jones, J. W., Cámara, M., Williams, P., Kane, M. A., & Oglesby-Sherrouse, A. G. (2016). Cystic Fibrosis isolates of Pseudomonas aeruginosa retain iron-regulated antimicrobial activity against Staphylococcus aureus through the action of multiple alkylquinolones. Frontiers in Microbiology, 7, https://doi.org/10.3389/fmicb.2016.01171

Cystic fibrosis (CF) is a hereditary disease that predisposes individuals to pulmonary dysfunction and chronic infections. Early infection of the CF lung with Staphylococcus aureus is common, while Pseudomonas aeruginosa becomes dominant as disease p... Read More about Cystic Fibrosis isolates of Pseudomonas aeruginosa retain iron-regulated antimicrobial activity against Staphylococcus aureus through the action of multiple alkylquinolones.

Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment (2015)
Journal Article
Magennis, E., Hook, A., Davies, M., Alexander, C., Williams, P., & Alexander, M. R. (2016). Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment. Acta Biomaterialia, 34, 84-92. https://doi.org/10.1016/j.actbio.2015.11.008

Controlling the colonisation of materials by microorganisms is important in a wide range of industries and clinical settings. To date, the underlying mechanisms that govern the interactions of bacteria with material surfaces remain poorly understood,... Read More about Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment.

Cationic polymer mediated bacterial clustering: cell-adhesive properties of homo- and copolymers (2015)
Journal Article
Louzao, I., Sui, C., Winzer, K., Fernandez-Trillo, F., & Alexander, C. (2015). Cationic polymer mediated bacterial clustering: cell-adhesive properties of homo- and copolymers. European Journal of Pharmaceutics and Biopharmaceutics, 95, 47-62. https://doi.org/10.1016/j.ejpb.2015.05.026

New anti-infective materials are needed urgently as alternatives to conventional biocides. It has recently been established that polymer materials designed to bind to the surface of bacteria can induce the formation of cell clusters which enhance the... Read More about Cationic polymer mediated bacterial clustering: cell-adhesive properties of homo- and copolymers.

Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies (2014)
Journal Article
Edwards, V. C., McClure, P., Brown, R. J., Thompson, E., Irving, W. L., & Ball, J. K. (in press). Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies. Journal of General Virology, 95(1), https://doi.org/10.1099/vir.0.057828-0

Sequence analysis is used to define the molecular epidemiology and evolution of the hepatitis C virus. Whilst most studies have shown that individual patients harbour viruses that are derived from a limited number of highly related strains, some rece... Read More about Use of short-tandem repeat (STR) fingerprinting to validate sample origins in hepatitis C virus molecular epidemiology studies.

Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis (2013)
Journal Article
Chan, X. Y., Chang, C. Y., Hong, K. W., Tee, K. K., Yin, W. F., & Chan, K. G. (2013). Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis. Gut Pathogens, 5(Octobe), Article 5. https://doi.org/10.1186/1757-4749-5-29

Background
Serratia marcescens is an opportunistic bacterial pathogen with broad range of host ranging from vertebrates, invertebrates and plants. S. marcescens strain W2.3 was isolated from a diseased tilapia fish and it was suspected to be the cau... Read More about Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis.