P102 Dissecting the metabolic impact of faecal microbiota transplantation (FMT) in C. difficile and E. coli infections using 3D OrbiSIMS
(2024)
Presentation / Conference Contribution
Qassadi, F., Kim, D.-H., Griffiths, R., Kao, D., Zhu, Z., & Monaghan, T. (2024, June). P102 Dissecting the metabolic impact of faecal microbiota transplantation (FMT) in C. difficile and E. coli infections using 3D OrbiSIMS. Presented at BSG LIVE’24, Birmingham, UK
TANYA MONAGHAN's Outputs (13)
Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave (2024)
Journal Article
Acheampong, E., Husain, A. A., Dudani, H., Nayak, A. R., Nag, A., Meena, E., …Monaghan, T. M. (2024). Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave. PLoS ONE, 19(5), Article e0303529. https://doi.org/10.1371/journal.pone.0303529Wastewater-based epidemiology (WBE) has emerged as an effective environmental surveillance tool for predicting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease outbreaks in high-income countries (HICs) with centralized sewage infr... Read More about Population infection estimation from wastewater surveillance for SARS-CoV-2 in Nagpur, India during the second pandemic wave.
Fecal microbiota transplantation: current challenges and future landscapes (2024)
Journal Article
Yadegar, A., Bar-Yoseph, H., Monaghan, T. M., Severino, A., Pakpour, S., Kuijper, E. J., …Kao, D. (2024). Fecal microbiota transplantation: current challenges and future landscapes. Clinical Microbiology Reviews, 37(2), Article e00060-22. https://doi.org/10.1128/cmr.00060-22Given the importance of gut microbial homeostasis in maintaining health, there has been considerable interest in developing innovative therapeutic strategies for restoring gut microbiota. One such approach, fecal microbiota transplantation (FMT), is... Read More about Fecal microbiota transplantation: current challenges and future landscapes.
Case Series: Efficacy of Polyclonal Intravenous Immunoglobulin for Refractory Clostridioides difficile Infection (2024)
Journal Article
Ragan, S. A., Doyle, C., Datta, N., Abdic, H., Wilcox, M. H., Montgomery, R., …Monaghan, T. M. (2024). Case Series: Efficacy of Polyclonal Intravenous Immunoglobulin for Refractory Clostridioides difficile Infection. Antibodies, 13(2), Article 26. https://doi.org/10.3390/antib13020026Background: Intravenous immunoglobulin (IVIg) for Clostridioides difficile infection (CDI) no longer features in treatment guidelines. However, IVIg is still used by some clinicians for severe or recurrent CDI (rCDI) cases. The main objective of this... Read More about Case Series: Efficacy of Polyclonal Intravenous Immunoglobulin for Refractory Clostridioides difficile Infection.
Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update (2024)
Journal Article
Hediyal, T. A., Vichitra, C., Anand, N., Bhaskaran, M., Essa, S. M., Kumar, P., …Chidambaram, S. B. (2024). Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update. Frontiers in Immunology, 15, Article 1324018. https://doi.org/10.3389/fimmu.2024.1324018The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (... Read More about Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update.
Sleep apnoea, gut dysbiosis and cognitive dysfunction (2023)
Journal Article
Deyang, T., Baig, A. I., Dolkar, P., Hediyal, T. A., Rathipriya, A. G., Bhaskaran, M., …Chidambaram, S. B. (2024). Sleep apnoea, gut dysbiosis and cognitive dysfunction. FEBS Journal, 291(12), 2519-2544. https://doi.org/10.1111/febs.16960Sleep disorders are becoming increasingly common, and their distinct effects on physical and mental health require elaborate investigation. Gut dysbiosis (GD) has been reported in sleep-related disorders, but sleep apnoea is of particular significanc... Read More about Sleep apnoea, gut dysbiosis and cognitive dysfunction.
Gut microbiome-based dietary intervention in Parkinson disease subject: A case report (2023)
Journal Article
Sulthana, A., Paneyala, S., Narayan, M. K., Ahmed Hediyal, T., Sharma, S., Senthilkumar, A., …Sulakhe, D. (2023). Gut microbiome-based dietary intervention in Parkinson disease subject: A case report. International Journal of Nutrition, Pharmacology, Neurological Diseases, 13(3), 158-165. https://doi.org/10.4103/ijnpnd.ijnpnd_8_23A 54-year-old woman was seeking medical treatment for Parkinson disease (PD) in the neurology outpatient department in JSS Hospital, Mysore, India. She was challenged in terms of reduced mobility and had sought several treatment options to control he... Read More about Gut microbiome-based dietary intervention in Parkinson disease subject: A case report.
Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection (2023)
Journal Article
Yadegar, A., Pakpoor, S. F., Ibrahim, F. F., Nabavi-Rad, A., Cook, L., Walter, J., …Kao, D. (2023). Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. Cell Host and Microbe, 31(5), 695-711. https://doi.org/10.1016/j.chom.2023.03.019Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rC... Read More about Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection.
RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance (2023)
Journal Article
Stockdale, S. R., Blanchard, A. M., Nayak, A., Husain, A., Nashine, R., Dudani, H., …Monaghan, T. M. (2023). RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance. The Lancet Regional Health – Southeast Asia, 14, Article 100205. https://doi.org/10.1016/j.lansea.2023.100205Background: The COVID-19 pandemic showcased the power of genomic sequencing to tackle the emergence and spread of infectious diseases. However, metagenomic sequencing of total microbial RNAs in wastewater has the potential to assess multiple infectio... Read More about RNA-Seq of untreated wastewater to assess COVID-19 and emerging and endemic viruses for public health surveillance.
The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation (2023)
Journal Article
Nabavi-Rad, A., Jamshidizadeh, S., Azizi, M., Yadegar, A., Robinson, K., Monaghan, T. M., & Reza Zali, M. (2023). The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation. Frontiers in Cellular and Infection Microbiology, 13, Article 1171469Owing to the emergence and spread of multidrug resistance mechanisms in Helicobacter pylori, achieving a successful eradication has become exceedingly difficult. Thus, this study for the first time determines the effect of a combination of vitamin D3... Read More about The synergistic effect of Levilactobacillus breves IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation.
Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention (2023)
Journal Article
Monaghan, T. M., Ugun-Klusek, A., Finelli, M., Gurnani, P., Chakrabarti, L., Kao, D., …Polytarchou, C. (2024). Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention. Gut, 73(6), 1034-1036. https://doi.org/10.1136/gutjnl-2022-327301
Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory (2023)
Journal Article
Meng, G., Monaghan, T. M., Duggal, N. A., Tighe, P., & Peerani, F. (2023). Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory. Journal of Crohn's and Colitis, 17(8), 1309-1325. https://doi.org/10.1093/ecco-jcc/jjad025Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite th... Read More about Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory.
Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria (2023)
Journal Article
Qassadi, F. I., Zhu, Z., & Monaghan, T. M. (2023). Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria. Pathogens, 12(2), Article 333. https://doi.org/10.3390/pathogens12020333The rising burden of antimicrobial resistance and increasing infectious disease outbreaks, including the recent COVID-19 pandemic, has led to a growing demand for the development of natural products as a valuable source of leading medicinal compounds... Read More about Plant-Derived Products with Therapeutic Potential against Gastrointestinal Bacteria.