Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models
(2024)
Journal Article
Peach, C. J., Tonello, R., Damo, E., Gomez, K., Calderon-Rivera, A., Bruni, R., Bansia, H., Maile, L., Manu, A.-M., Hahn, H., Thomsen, A. R., Schmidt, B. L., Davidson, S., des Georges, A., Khanna, R., & Bunnett, N. W. (2025). Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models. Journal of Clinical Investigation, 135(4), Article e183873. https://doi.org/10.1172/jci183873
Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain, yet failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a coreceptor for NGF and tropomyosin-related kinase A (Tr...
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