Guanmin Meng
Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory
Meng, Guanmin; Monaghan, Tanya M.; Duggal, Niharika A.; Tighe, Paddy; Peerani, Farhad
Authors
TANYA MONAGHAN Tanya.Monaghan@nottingham.ac.uk
Clinical Associate Professor in Luminal Gastroenterology
Niharika A. Duggal
PATRICK TIGHE paddy.tighe@nottingham.ac.uk
Professor of Molecular Immunology
Farhad Peerani
Abstract
Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite the foreseeable high demand for personalized medicine and specialized IBD care in the elderly, current paradigms of IBD management fail to capture the required nuances of care for elderly-onset IBD patients. Our review postulates the roles of systemic and mucosal immunosenescence, inflammageing and a dysbiotic microbial ecosystem in the pathophysiology of elderly-onset IBD. Ultimately, a better understanding of elderly-onset IBD can lead to improved patient outcomes and the tailoring of future preventative and treatment strategies.
Citation
Meng, G., Monaghan, T. M., Duggal, N. A., Tighe, P., & Peerani, F. (2023). Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory. Journal of Crohn's and Colitis, 17(8), 1309-1325. https://doi.org/10.1093/ecco-jcc/jjad025
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 1, 2023 |
Online Publication Date | Feb 20, 2023 |
Publication Date | 2023-08 |
Deposit Date | Feb 13, 2023 |
Publicly Available Date | Feb 21, 2024 |
Journal | Journal of Crohn's and Colitis |
Electronic ISSN | 1876-4479 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 17 |
Issue | 8 |
Article Number | jjad025 |
Pages | 1309-1325 |
DOI | https://doi.org/10.1093/ecco-jcc/jjad025 |
Keywords | Inflammatory Bowel Disease, Gut Microbiota, Immunosenescence, Intestinal Barrier Permeability, Inflammaging, Aging |
Public URL | https://nottingham-repository.worktribe.com/output/17375968 |
Publisher URL | https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjad025/7048942?redirectedFrom=fulltext&login=false |
Additional Information | This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Crohn's and Colitis following peer review. The version of record Guanmin Meng, Tanya M Monaghan, Niharika A Duggal, Paddy Tighe, Farhad Peerani, Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory, Journal of Crohn's and Colitis, 2023;, jjad025 is available online at: https://doi.org/10.1093/ecco-jcc/jjad025. |
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