Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection

Yadegar, Abbas; Pakpoor, Sepideh F.; Ibrahim, Fathima F.; Nabavi-Rad, Ali; Cook, Laura; Walter, Jens; Seekatz, Anna M.; Wong, Karen; Monaghan, Tanya M.; Kao, Dina

Abstract

Fecal microbiota transplantation (FMT) is highly effective in preventing recurrent Clostridioides difficile infection (rCDI). However, the mechanisms underpinning its clinical efficacy are incompletely understood. Herein, we provide an overview of rCDI pathogenesis followed by a discussion of potential mechanisms of action focusing on the current understanding of trans-kingdom microbial, metabolic, immunological, and epigenetic mechanisms. We then outline the current research gaps and offer methodological recommendations for future studies to elevate the quality of research and advance knowledge translation. By combining interventional trials with multiomics technology and host and environmental factors, analyzing longitudinally collected biospecimens will generate results that can be validated with animal and other models. Collectively, this will confirm causality and improve translation, ultimately to develop targeted therapies to replace FMT.

Citation

Yadegar, A., Pakpoor, S. F., Ibrahim, F. F., Nabavi-Rad, A., Cook, L., Walter, J., Seekatz, A. M., Wong, K., Monaghan, T. M., & Kao, D. (2023). Beneficial effects of fecal microbiota transplantation in recurrent Clostridioides difficile infection. Cell Host and Microbe, 31(5), 695-711. https://doi.org/10.1016/j.chom.2023.03.019

• Journal Article Type: Review
• Acceptance Date: Mar 14, 2023
• Online Publication Date: May 10, 2023
• Publication Date: May 10, 2023
• Deposit Date: Mar 25, 2023
• Publicly Available Date: May 11, 2024
• Journal: Cell Host and Microbe
• Print ISSN: 1931-3128
• Electronic ISSN: 1934-6069
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 31
• Issue: 5
• Pages: 695-711
• DOI: https://doi.org/10.1016/j.chom.2023.03.019
• Keywords: Recurrent Clostridioides difficile infection; fecal microbiota transplantation; intestinal microbial transfer; host-microbial interactions
• Public URL: https://nottingham-repository.worktribe.com/output/18850941
• Publisher URL: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00124-5