Outputs (30)

Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression (2025)
Journal Article
Kader, T., Zethoven Sakshi Mahale, M., Saunders, H., Tjoeka, L., Lehmann, R., Jayawardana, M. W., Pang, J.-M., Lesche, D., Rajan, N., Semple, T., Er Amanda Lee, J., Lupat, R., Byrne, D. J., Hughes, S., Nguyen, H., Lai, S., Pechlivanis, M., Craig, O., Devereux, L., House, E., …Gorringe, K. L. (in press). Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression. Journal of Pathology,

Development of ipsilateral breast carcinoma following diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not be the case and it is important to know how often recurren... Read More about Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression.

Infrared and Raman spectroscopy of blood plasma for rapid endometrial cancer detection (2025)
Journal Article
Schiemer, R., Grant, J., Shafiee, M. N., Phang, S., Furniss, D., Boitor, R., Seddon, A. B., Notingher, I., Atiomo, W., Jones, N. W., & Gajjar, K. B. (2025). Infrared and Raman spectroscopy of blood plasma for rapid endometrial cancer detection. British Journal of Cancer, https://doi.org/10.1038/s41416-025-03050-0

Background: Endometrial cancer (EC) is the 6th most common cancer among women worldwide. No effective non-invasive screening methods or approved blood biomarkers for EC exist. Previous research explored Attenuated Total Reflection-Fourier Transform I... Read More about Infrared and Raman spectroscopy of blood plasma for rapid endometrial cancer detection.

A systematic review exploring perceptions of Tourette syndrome and tic disorders using the common-sense model of illness representations (2025)
Journal Article
Petter, C., Khan, K., Babbage, C., & Davies, E. B. (2025). A systematic review exploring perceptions of Tourette syndrome and tic disorders using the common-sense model of illness representations. Psychology and Health, 1-34. https://doi.org/10.1080/08870446.2025.2502515

Objective: Tic disorders (TDs) are neurodevelopmental conditions characterised by tics and typically appear during childhood. The Common Sense Model of Self-Regulation (CSM) provides a useful theoretical framework for understanding health beliefs in... Read More about A systematic review exploring perceptions of Tourette syndrome and tic disorders using the common-sense model of illness representations.

Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation (2025)
Journal Article
Wijayasiri, P., Astbury, S., Needham, G., Kaye, P., Bhat, M., Piccinini, A. M., & Aravinthan, A. D. (2025). Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation. Human Cell, 38(3), Article 70. https://doi.org/10.1007/s13577-025-01201-2

Accumulation of senescent hepatocytes is universal in chronic liver disease (CLD). This study investigates an association between hepatocyte senescence and hepatocellular carcinoma (HCC) and explores the therapeutic role of sirolimus. Background live... Read More about Role of hepatocellular senescence in the development of hepatocellular carcinoma and the potential for therapeutic manipulation.

Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon (2024)
Journal Article
Almozyan, S., Babaei-Jadidi, R., Aljohani, A., Youssefi, S., Dalleywater, W., Kadam, P., Spencer-Dene, B., Rakha, E., Ilyas, M., & Shams Nateri, A. (2025). Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon. Cancer Communications, 45(1), 9-14. https://doi.org/10.1002/cac2.12625

Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke (2024)
Journal Article
Li, G., Lin, Y., Yang, J., Anderson, C. S., Chen, C., Liu, F., Billot, L., Li, Q., Chen, X., Liu, X., Ren, X., Zhang, C., Xu, P., Wu, L., Wang, F., Qiu, D., Jiang, M., Peng, Y., Li, C., Huang, Y., …Song, L. (2024). Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke. New England Journal of Medicine, 390(20), 1862-1872. https://doi.org/10.1056/nejmoa2314741

Background

Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute... Read More about Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke.

Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study (2024)
Journal Article
Kalenderski, K., Dubern, J.-F., Lewis-Lloyd, C., Jeffery, N., Heeb, S., Irvine, D. J., Sloan, T. J., Birch, B., Andrich, D., Humes, D., Alexander, M. R., & Williams, P. (2024). Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study. Journal of Urology Open PLus, 2(1), Article e00005. https://doi.org/10.1097/JU9.0000000000000097

Purpose: Biofilm formation and biomineralization on urinary catheters may cause severe complications including infection and obstruction. Here, we describe an in vitro evaluation and prospective pilot clinical study of a silicone catheter coated with... Read More about Polymer-Coated Urinary Catheter Reduces Biofilm Formation and Biomineralization: A First-in-Man, Prospective Pilot Study.

Osteoarthritis pain phenotypes: How best to cut the cake? (2023)
Journal Article
Smith, S. L., & Walsh, D. A. (2023). Osteoarthritis pain phenotypes: How best to cut the cake?. Osteoarthritis and Cartilage, Article S1063-4584(23)00986-X. https://doi.org/10.1016/j.joca.2023.11.008

Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study (2023)
Journal Article
Szatkowski, L., Sharkey, D., Budge, H., & Ojha, S. (2023). Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study. eClinicalMedicine, 65, Article 102296. https://doi.org/10.1016/j.eclinm.2023.102296

Background: Preterm infants often require mechanical ventilation (MV), which can be a painful experience. Opioids (such as morphine) are used to provide analgesia, despite conflicting evidence about their impact on the developing brain. We aimed to q... Read More about Association between opioid use during mechanical ventilation in preterm infants and evidence of brain injury: a propensity score-matched cohort study.

Optimizing implementation of eHealth for dementia: Lessons from developing an eHealth Implementation Readiness (EmpRess) checklist (2023)
Presentation / Conference Contribution
Christie, H. L., Atefi, G. L., Craven, M. P., Orrell, M., & de Vugt, M. E. (2023, October). Optimizing implementation of eHealth for dementia: Lessons from developing an eHealth Implementation Readiness (EmpRess) checklist. Poster presented at 33rd Alzheimer Europe Conference, Helsinki, Finland

Situation: eHealth interventions are a possible solution for rising dementia care costs and potential negative effects on carers

Problem: Few evidence-based eHealth interventions are implemented in practice

Solution :
Adapt existing implementa... Read More about Optimizing implementation of eHealth for dementia: Lessons from developing an eHealth Implementation Readiness (EmpRess) checklist.

The bidirectional relationship between chronic joint pain and frailty: data from the Investigating Musculoskeletal Health and Wellbeing cohort (2023)
Journal Article
Chaplin, W. J., McWilliams, D. F., Millar, B. S., Gladman, J. R. F., & Walsh, D. A. (2023). The bidirectional relationship between chronic joint pain and frailty: data from the Investigating Musculoskeletal Health and Wellbeing cohort. BMC Geriatrics, 23(1), Article 273. https://doi.org/10.1186/s12877-023-03949-4

Background: Pain and frailty are associated, but this relationship is insufficiently understood. We aimed to test whether there is a unidirectional or bidirectional relationship between joint pain and frailty. Methods: Data were from Investigating Mu... Read More about The bidirectional relationship between chronic joint pain and frailty: data from the Investigating Musculoskeletal Health and Wellbeing cohort.

Haematology (2023)
Book Chapter
Richardson, R., & Ellis, R. (2023). Haematology. In General Medicine and Surgery: Medical student revision guide (59-81). (1). Scion Publishing

A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes (2022)
Journal Article
Ruaux, S., & Chadborn, N. (2023). A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes. Journal of Integrated Care, 31(1), 64-74. https://doi.org/10.1108/JICA-11-2021-0060

Purpose: Older people who reside in care homes have varying access and quality of medical care; in the UK, this is provided by general practitioners (GPs). The authors aimed to explore the experiences of trainee GPs in delivering integrated care and... Read More about A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes.

Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink (2022)
Journal Article
Abhishek, A., Cipolletta, E., Nakafero, G., Avery, A. J., Mamas, M., & Tata, L. J. (2022). Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 81(12), https://doi.org/10.1136/ard-2022-222668

Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids (2022)
Journal Article
Babaei-Jadidi, R., Kashfi, H., Alelwani, W., Bakhtiari, A., Kattan, S. W., Mansouri, O. A., Mukherjee, A., Lobo, D. N., & Nateri, A. S. (2022). Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids. Oncogenesis, 11, Article 4. https://doi.org/10.1038/s41389-021-00376-1

Little is known about the role of microRNAs (miRNAs) in rewiring the metabolism within tumours and adjacent non-tumour bearing normal tissue and their potential in cancer therapy. This study aimed to investigate the relationship between deregulated m... Read More about Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids.

The effect of stimulus duration on preferences for gain adjustments when listening to speech (2021)
Journal Article
Whitmer, W. M., Caswell-Midwinter, B., & Naylor, G. (2022). The effect of stimulus duration on preferences for gain adjustments when listening to speech. International Journal of Audiology, 61(11), 940-947. https://doi.org/10.1080/14992027.2021.1998676

Objectives: In the personalisation of hearing-aid fittings, gain is often adjusted to suit patient preferences using live speech. When using brief sentences as stimuli, the minimum gain adjustments necessary to elicit consistent preferences (“prefere... Read More about The effect of stimulus duration on preferences for gain adjustments when listening to speech.

Clinical Trials and Outcome Measures in Adults With Hearing Loss (2021)
Journal Article
Munro, K. J., Whitmer, W. M., & Heinrich, A. (2021). Clinical Trials and Outcome Measures in Adults With Hearing Loss. Frontiers in Psychology, 12, Article 733060. https://doi.org/10.3389/fpsyg.2021.733060

Clinical trials are designed to evaluate interventions that prevent, diagnose or treat a health condition and provide the evidence base for improving practice in health care. Many health professionals, including those working within or allied to hear... Read More about Clinical Trials and Outcome Measures in Adults With Hearing Loss.

Essential guide to acute care (2020)
Book
Cooper, N., Cramp, P., Forrest, K., & Patel, R. (2020). Essential guide to acute care. (3rd edition). Wiley

The best-selling Essential Guide to Acute Care contains everything you need to know about acute care that you can’t find in a standard textbook. The third edition has been extensively revised and updated, presenting new oxygen guidelines, updated evi... Read More about Essential guide to acute care.

Exploring the Factor Structure of the Glasgow Children’s Benefit Inventory: New Recommendations for Reporting Results (2020)
Journal Article
Kubba, H., & Whitmer, W. M. (2021). Exploring the Factor Structure of the Glasgow Children’s Benefit Inventory: New Recommendations for Reporting Results. Annals of Otology, Rhinology & Laryngology, 130(6), 614-622. https://doi.org/10.1177/0003489420965634

Objective
Patient-reported outcomes can be useful for reporting benefit from non-life-saving interventions, but often they report a single overall score, which means that much information on the specific areas of benefit is lost. Our aim was to per... Read More about Exploring the Factor Structure of the Glasgow Children’s Benefit Inventory: New Recommendations for Reporting Results.

In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers (2020)
Journal Article
Atkinson, S. R., Grove, J. I., Liebig, S., Astbury, S., Vergis, N., Goldin, R., Quaglia, A., Bantel, H., Neil Guha, I., Thursz, M. R., Newcombe, P., Strnad, P., & Aithal, G. P. (2020). In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers. American Journal of Gastroenterology, 115(11), 1857-1868. https://doi.org/10.14309/ajg.0000000000000912

INTRODUCTION:

Up to 40% of patients with severe alcoholic hepatitis (AH) die within 6 months of presentation, making prompt diagnosis and appropriate treatment essential. We determined the associations between serum keratin-18 (K18) and histologi... Read More about In severe alcoholic hepatitis, serum cytokeratin-18 fragments are diagnostic, prognostic and theragnostic biomarkers.