Outputs (4)

The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions (2022)
Journal Article
Steinert, J. R., & Amal, H. (2023). The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions. Free Radical Biology and Medicine, 194, 71-83. https://doi.org/10.1016/j.freeradbiomed.2022.11.035

Nitric oxide and other redox active molecules such as oxygen free radicals provide essential signalling in diverse neuronal functions, but their excess production and insufficient scavenging induces cytotoxic redox stress which is associated with num... Read More about The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions.

Redox stress and metal dys-homeostasis appear as hallmarks of early prion disease pathogenesis in mice (2022)
Journal Article
Spiers, J. G., Cortina Chen, H. J., Barry, T. L., Bourgognon, J. M., & Steinert, J. R. (2022). Redox stress and metal dys-homeostasis appear as hallmarks of early prion disease pathogenesis in mice. Free Radical Biology and Medicine, 192, 182-190. https://doi.org/10.1016/j.freeradbiomed.2022.09.025

Neurodegenerative diseases are associated with a multitude of dysfunctional cellular pathways. One major contributory factor is a redox stress challenge during the development of several protein misfolding conditions including Alzheimer's (AD), Parki... Read More about Redox stress and metal dys-homeostasis appear as hallmarks of early prion disease pathogenesis in mice.

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse (2022)
Journal Article
Richardson, A., Ciampani, V., Stancu, M., Bondarenko, K., Newton, S., Steinert, J. R., …Forsythe, I. D. (2022). Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse. eLife, 11, Article e75219. https://doi.org/10.7554/eLife.75219

Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3.1 and Kv3.3 are highly expressed in the auditory brainstem and we exploited thi... Read More about Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse.

Author response: Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse (2022)
Other
Richardson, A., Ciampani, V., Stancu, M., Bondarenko, K., Newton, S., Steinert, J. R., …Forsythe, I. D. (2022). Author response: Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse. [elife]